Ventricular Remodeling

Publication Title: 
The Tohoku Journal of Experimental Medicine

Myocardial infarction (MI) leads to progressive left ventricular (LV) dilatation and is associated with interstitial fibrosis in the non-infarcted myocardium. The NF-?B signaling pathway plays an important role in ventricular remodeling after MI. Recent studies have indicated that the anti-malarial agent artemisinin can inhibit NF-?B activation, which may attenuate post-infarct myocardial remodeling. In this study, we investigated the effect of artemisinin on post-infarct myocardial remodeling using a rat model of MI.

Author(s): 
Gu, Yongwei
Wang, Xi
Wang, Xin
Yuan, Mingjie
Wu, Gang
Hu, Juan
Tang, Yanhong
Huang, Congxin
Publication Title: 
Canadian Journal of Physiology and Pharmacology

Ayurveda is an Indian system of medicine. Despite clinical efficacy, lack of scientific validation has limited the effective use of Ayurvedic drugs. Cardoguard is an Ayurvedic antihypertensive drug formulated by Nagarjuna Herbal Concentrates Ltd., Kerala, India. Left ventricular hypertrophy (LVH) is a modifiable risk factor, and regression of LVH reduces the propensity for adverse cardiovascular events. This study was taken up with the objective of evaluating the efficacy of Cardoguard in the prevention of cardiac remodeling.

Author(s): 
Sankar, Vandana
Nair, Renuka R.
Harikrishnan, Vijayakumar S.
Fernandez, Adelaide C.
Kumar, Cherumanal S. Krishna
Madhavachandran, Viswanathamenon
Publication Title: 
American Journal of Physiology. Heart and Circulatory Physiology

Metabolic syndrome (MetS) represents an increased risk of cardiovascular disease. Although its individual components adversely affect cardiac structure and function, the extent to which multiple components of MetS affect the cardiac extracellular matrix (ECM) has not been well characterized. Lysyl oxidase (LOX) is one of the cardiac ECM-modifying enzymes that catalyze the formation of collagen cross-linking. Our objective was to define the effect of diet-induced MetS on the LOX enzyme.

Author(s): 
Zibadi, Sherma
Vazquez, Randy
Moore, Derek
Larson, Douglas F.
Watson, Ronald R.
Publication Title: 
Journal of the American College of Cardiology

OBJECTIVES: The objective of this prospective, single-site, 2-year dietary intervention study was to evaluate the effects of moderate weight reduction and subsequent partial weight regain on cardiovascular structure and function. BACKGROUND: Obesity is associated with adverse cardiac and vascular structural and functional alterations. METHODS: Sixty obese subjects (age 46 + or - 10 years, body mass index 37 + or - 3 kg/m(2)) were evaluated during their participation in a weight loss study.

Author(s): 
de las Fuentes, Lisa
Waggoner, Alan D.
Mohammed, B. Selma
Stein, Richard I.
Miller, Bernard V.
Foster, Gary D.
Wyatt, Holly R.
Klein, Samuel
Davila-Roman, Victor G.
Publication Title: 
Journal of the American College of Cardiology

OBJECTIVES: We examined the effects of the flavanol (-)-epicatechin on short- and long-term infarct size and left ventricular (LV) structure and function after permanent coronary occlusion (PCO) and the potential involvement of the protective protein kinase B (AKT)/extracellular signal-related kinase (ERK) signaling pathways. BACKGROUND: (-)-epicatechin reduces blood pressure in hypertensive patients and limits infarct size in animal models of myocardial ischemia-reperfusion injury. However, nothing is known about its effects on infarction after PCO.

Author(s): 
Yamazaki, Katrina Go
Taub, Pam R.
Barraza-Hidalgo, Maraliz
Rivas, Maria M.
Zambon, Alexander C.
Ceballos, Guillermo
Villarreal, Francisco J.
Publication Title: 
Circulation Research

RATIONALE: Hyperamylinemia is common in patients with obesity and insulin resistance, coincides with hyperinsulinemia, and results in amyloid deposition. Amylin amyloids are generally considered a pancreatic disorder in type 2 diabetes. However, elevated circulating levels of amylin may also lead to amylin accumulation and proteotoxicity in peripheral organs, including the heart. OBJECTIVE: To test whether amylin accumulates in the heart of obese and type 2 diabetic patients and to uncover the effects of amylin accumulation on cardiac morphology and function.

Author(s): 
Despa, Sanda
Margulies, Kenneth B.
Chen, Le
Knowlton, Anne A.
Havel, Peter J.
Taegtmeyer, Heinrich
Bers, Donald M.
Despa, Florin
Publication Title: 
Circulation Research

RATIONALE: Matrix metalloproteinase (MMP)-28 regulates the inflammatory and extracellular matrix responses in cardiac aging, but the roles of MMP-28 after myocardial infarction (MI) have not been explored. OBJECTIVE: To determine the impact of MMP-28 deletion on post-MI remodeling of the left ventricle (LV). METHODS AND RESULTS: Adult C57BL/6J wild-type (n=76) and MMP null (MMP-28((-/-)), n=86) mice of both sexes were subjected to permanent coronary artery ligation to create MI. MMP-28 expression decreased post-MI, and its cell source shifted from myocytes to macrophages.

Author(s): 
Ma, Yonggang
Halade, Ganesh V.
Zhang, Jianhua
Ramirez, Trevi A.
Levin, Daniel
Voorhees, Andrew
Jin, Yu-Fang
Han, Hai-Chao
Manicone, Anne M.
Lindsey, Merry L.
Publication Title: 
Pharmacology & Therapeutics

Adverse cardiac remodeling following myocardial infarction (MI) remains a significant cause of congestive heart failure. Additional and novel strategies that improve our ability to predict, diagnose, or treat remodeling are needed. Numerous groups have explored single and multiple biomarker strategies to identify diagnostic prognosticators of remodeling progression, which will improve our ability to promptly and accurately identify high-risk individuals. The identification of better clinical indicators should further lead to more effective prediction and timely treatment.

Author(s): 
Halade, Ganesh V.
Jin, Yu-Fang
Lindsey, Merry L.
Publication Title: 
Journal of Proteomics

The extracellular matrix (ECM) is a critical tissue component, providing structural support as well as important regulatory signaling cues to govern cellular growth, metabolism, and differentiation. The study of ECM proteins, however, is hampered by the low solubility of ECM components in common solubilizing reagents. ECM proteins are often not detected during proteomics analyses using unbiased approaches due to solubility issues and relatively low abundance compared to highly abundant cytoplasmic and mitochondrial proteins.

Author(s): 
de Castro Brás, Lisandra E.
Ramirez, Trevi A.
DeLeon-Pennell, Kristine Y.
Chiao, Ying Ann
Ma, Yonggang
Dai, Qiuxia
Halade, Ganesh V.
Hakala, Kevin
Weintraub, Susan T.
Lindsey, Merry L.
Publication Title: 
Cardiovascular Pathology: The Official Journal of the Society for Cardiovascular Pathology

BACKGROUND: Introduction of the yellow obese gene (A(y)) into mice (KKAy) results in obesity and diabetes by 5 weeks of age. METHODS: Using this model of type 2 diabetes, we evaluated male and female 6- to 8-month-old wild-type (WT, n=10) and KKAy (n=22) mice subjected to myocardial infarction (MI) and sacrificed at day (d) 7. RESULTS: Despite similar infarct sizes (50% ± 4% for WT and 49% ± 2% for KKAy, P=not significant), the 7d post-MI survival was 70% (n=7/10) in WT mice and 45% (n=10/22) in KKAy mice (P<.05).

Author(s): 
Heaberlin, James R.
Ma, Yonggang
Zhang, Jianhua
Ahuja, Seema S.
Lindsey, Merry L.
Halade, Ganesh V.

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