Vero Cells

Publication Title: 
Antiviral Research

Traditional herbal medicines have been safely used for the treatment of various human diseases since ancient China. We selected 10 herbal extracts with therapeutic antiherpes simplex virus type 1 (HSV-1) activity. Among these, Geum japonicum Thunb., Rhus javanica L., Syzygium aromaticum (L.) Merr. et Perry, or Terminalia chebula Retzus showed a stronger anti-HSV-1 activity in combination with acyclovir than the other herbal extracts in vitro.

Author(s): 
Kurokawa, M.
Nagasaka, K.
Hirabayashi, T.
Uyama, S.
Sato, H.
Kageyama, T.
Kadota, S.
Ohyama, H.
Hozumi, T.
Namba, T.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Development of new and effective therapeutics for sexually transmitted herpes simplex virus-2 (HSV-2) infection is important from public health perspective. With an aim to identify natural products from medicinal plants, in the present study, the potential of Terminalia chebula Retz was investigated for its activity against HSV-2. METHODS: Fruits of Terminalia chebula Retz were used to prepare 50% ethanolic extract. In addition, chebulagic acid and chebulinic acid both purified from T. chebula were also used.

Author(s): 
Kesharwani, Ajay
Polachira, Suja Kizhiyedath
Nair, Reshmi
Agarwal, Aakanksha
Mishra, Nripendra Nath
Gupta, Satish Kumar
Publication Title: 
The American Journal of Tropical Medicine and Hygiene

Dengue virus (DENV) is considered to be the most important arthropod-borne viral disease and causes more than 100 million human infections annually. To further characterize primary DENV infection in vivo, rhesus macaques were infected with DENV-1, DENV-2, DENV-3, or DENV-4 and clinical parameters, as well as specificity and longevity of serologic responses, were assessed. Overt clinical symptoms were not present after infection.

Author(s): 
Hickey, Andrew C.
Koster, Jacob A.
Thalmann, Claudia M.
Hardcastle, Kathy
Tio, Phaik-Hooi
Cardosa, Mary J.
Bossart, Katharine N.
Publication Title: 
Antimicrobial Agents and Chemotherapy

We previously reported that among a series of artemisinin-derived monomers and dimers, dimer diphenyl phosphate (838) was the most potent inhibitor of human cytomegalovirus (CMV) replication. Our continued investigation of a prototypic artemisinin monomer (artesunate [AS]) and dimer (838) now reveals that both compounds have specific activity against CMV but do not inhibit lytic replication of human herpesvirus 1 or 2 or Epstein-Barr virus.

Author(s): 
He, Ran
Park, Kyoungsook
Cai, Hongyi
Kapoor, Arun
Forman, Michael
Mott, Bryan
Posner, Gary H.
Arav-Boger, Ravit
Publication Title: 
Phytotherapy research: PTR

Following chemotaxonomic evidence, the PE and CHCl(3) extracts of the roots of the botanical Angelica sinensis (Oliv.) Diels (Dang Gui) were investigated for in vitro anti-TB activity, in parallel to studying their serotonergic and GABAergic potential. The activities were confirmed to overlap chemically with the neurotropic active principles present in medium lipophilic fractions.

Author(s): 
Deng, Shixin
Wang, Yuehong
Inui, Taichi
Chen, Shao-Nong
Farnsworth, Norman R.
Cho, Sanghyun
Franzblau, Scott G.
Pauli, Guido F.
Publication Title: 
Journal of Ethnopharmacology

AIM OF THE STUDY: Parkinson's disease is a neurological disorder mostly effecting the elder population of the world. Currently there is no definitive treatment or cure for this disease. Therefore, in this study the composition and constituents of the aqueous extract of Banisteriopsis caapi for monoamine oxidases (MAO) inhibitory and antioxidant activities were assessed, which are relevant to the prevention of neurological disorders, including Parkinsonism.

Author(s): 
Samoylenko, Volodymyr
Rahman, Md Mostafizur
Tekwani, Babu L.
Tripathi, Lalit M.
Wang, Yan-Hong
Khan, Shabana I.
Khan, Ikhlas A.
Miller, Loren S.
Joshi, Vaishali C.
Muhammad, Ilias
Publication Title: 
Microbiological Research

The aim of this study was to evaluate the antiviral potential of methanolic extract (ME) of Achyranthes aspera, an Indian folk medicine and one of its pure compound oleanolic acid (OA) against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2). The ME possessed weak anti-herpes virus activity (EC50 64.4μg/ml for HSV-1 and 72.8μg/ml for HSV-2). While OA exhibited potent antiherpesvirus activity against both HSV-1 (EC50 6.8μg/ml) and HSV-2 (EC50 7.8μg/ml). The time response study revealed that the antiviral activity of ME and OA is highest at 2-6h post infection.

Author(s): 
Mukherjee, Hemanta
Ojha, Durbadal
Bag, Paromita
Chandel, Himanshu Singh
Bhattacharyya, Souvik
Chatterjee, Tapan K.
Mukherjee, Pulok K.
Chakraborti, Sekhar
Chattopadhyay, Debprasad
Publication Title: 
Marine Drugs

Sargassum naozhouense is a brown seaweed used in folk medicine and applied for thousands of years in Zhanjiang, Guangdong province, China. This study is the first time to investigate its chemical composition and antiviral activity. On the dry weight basis, this seaweed was constituted of ca. 35.18% ash, 11.20% protein, 1.06% lipid and 47.73% total carbohydrate, and the main carbohydrate was water-soluble polysaccharide. The protein analysis indicated the presence of essential amino acids, which accounted for 36.35% of the protein.

Author(s): 
Peng, Yan
Xie, Enyi
Zheng, Kai
Fredimoses, Mangaladoss
Yang, Xianwen
Zhou, Xuefeng
Wang, Yifei
Yang, Bin
Lin, Xiuping
Liu, Juan
Liu, Yonghong
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Plants of the genus Maytenus belong to the family Celastraceae and are widely used in folk medicine as anti-tumour, anti-asthmatic, analgesic, anti-inflammatory, antimicrobial and anti-ulcer agents, and as a treatment for stomach problems. The aim of this study was to isolate and identify active compounds with antifungal activity from Maytenus undata after a preliminary study highlighted promising activity in crude extracts. METHODS: Sequential extracts of M.

Author(s): 
Mokoka, Tsholofelo Abednego
McGaw, Lyndy Joy
Mdee, Ladislaus Kakore
Bagla, Victor Patrick
Iwalewa, Ezekiel Olugbenga
Eloff, Jacobus Nicolaas
Publication Title: 
PloS One

Podophyllotoxin (POD) is a lignan-type toxin existing in many herbs used in folk medicine. Until now, no effective strategy is available for the management of POD intoxication. This study aims to determine the protective effects of flavonoids (quercetin and kaempferol) on POD-induced toxicity. In Vero cells, both flavonoids protected POD-induced cytotoxicity by recovering alleviating G2/M arrest, decreasing ROS generation and changes of membrane potential, and recovering microtubule structure.

Author(s): 
Li, Juan
Sun, Hua
Jin, Lu
Cao, Wei
Zhang, Jin
Guo, Chong-Yi
Ding, Ke
Luo, Cheng
Ye, Wen-Cai
Jiang, Ren-Wang

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