Vibrissae

Publication Title: 
Parkinsonism & Related Disorders

Dopaminergic anti-parkinsonian medications, such as levodopa (LD) cause drug-induced dyskinesias (DID) in majority of patients with Parkinson's disease (PD). Mucuna pruriens, a legume extensively used in Ayurveda to treat PD, is reputed to provide anti-parkinsonian benefits without inducing DID. We compared the behavioral effects of chronic parenteral administration of a water extract of M.

Author(s): 
Lieu, Christopher A.
Kunselman, Allen R.
Manyam, Bala V.
Venkiteswaran, Kala
Subramanian, Thyagarajan
Publication Title: 
Parkinsonism & Related Disorders

Dopaminergic anti-parkinsonian medications, such as levodopa (LD) cause drug-induced dyskinesias (DID) in majority of patients with Parkinson's disease (PD). Mucuna pruriens, a legume extensively used in Ayurveda to treat PD, is reputed to provide anti-parkinsonian benefits without inducing DID. We compared the behavioral effects of chronic parenteral administration of a water extract of M.

Author(s): 
Lieu, Christopher A.
Kunselman, Allen R.
Manyam, Bala V.
Venkiteswaran, Kala
Subramanian, Thyagarajan
Publication Title: 
Parkinsonism & Related Disorders

Dopaminergic anti-parkinsonian medications, such as levodopa (LD) cause drug-induced dyskinesias (DID) in majority of patients with Parkinson's disease (PD). Mucuna pruriens, a legume extensively used in Ayurveda to treat PD, is reputed to provide anti-parkinsonian benefits without inducing DID. We compared the behavioral effects of chronic parenteral administration of a water extract of M.

Author(s): 
Lieu, Christopher A.
Kunselman, Allen R.
Manyam, Bala V.
Venkiteswaran, Kala
Subramanian, Thyagarajan
Publication Title: 
Annals of Anatomy = Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft

Insufficient recovery after peripheral nerve injury has been attributed to (i) poor pathfinding of regrowing axons, (ii) excessive collateral axonal branching at the lesion site and (iii) polyneuronal innervation of the neuromuscular junctions (NMJ). The facial nerve transection model has been used initially to measure restoration of function after varying therapies and to examine the mechanisms underlying their effects. Since it is very difficult to control the navigation of several thousand axons, efforts concentrated on collateral branching and NMJ-polyinnervation.

Author(s): 
Skouras, Emmanouil
Ozsoy, Umut
Sarikcioglu, Levent
Angelov, Doychin N.
Publication Title: 
Advances in Anatomy, Embryology, and Cell Biology

Using a combined morphofunctional approach, we recently found that polyinnervation of the neuromuscular junction (NMJ) is the critical factor for recovery of function after transection and suture of the facial nerve. Since polyinnervation is activity-dependent and can be manipulated, we tried to design a clinically feasible therapy by electrical stimulation or by soft tissue massage. First, electrical stimulation was applied to the transected facial nerve or to paralyzed facial muscles.

Author(s): 
Angelov, Doychin N.
Publication Title: 
PloS One

BACKGROUND: Cross-modal plasticity is characterized as the hypersensitivity of remaining modalities after a sensory function is lost in rodents, which ensures their awareness to environmental changes. Cellular and molecular mechanisms underlying cross-modal sensory plasticity remain unclear. We aim to study the role of different types of neurons in cross-modal plasticity. METHODOLOGY/PRINCIPAL FINDINGS: In addition to behavioral tasks in mice, whole-cell recordings at the excitatory and inhibitory neurons, and their two-photon imaging, were conducted in piriform cortex.

Author(s): 
Ye, Bing
Huang, Li
Gao, Zilong
Chen, Ping
Ni, Hong
Guan, Sudong
Zhu, Yan
Wang, Jin-Hui
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