Viral Load

Publication Title: 
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America

BACKGROUND: Despite advances in human immunodeficiency virus (HIV) treatment, major challenges remain in achieving access, retention, and adherence. Our inner-city HIV clinical practice in Baltimore has a diverse patient population with high rates of poverty, black race, and injection drug use (IDU), providing us the opportunity to compare health process and outcomes.

Author(s): 
Moore, Richard D.
Keruly, Jeanne C.
Bartlett, John G.
Publication Title: 
AIDS patient care and STDs

The increased longevity afforded by combination antiretroviral therapy in developed countries has led to an increased concern regarding senescence-related diseases in patients with human immunodeficiency virus (HIV) infection. Previous epidemiologic analyses have demonstrated an increased risk of chronic obstructive pulmonary disease, as well as a significant burden of respiratory symptoms in HIV-infected patients. We performed the St.

Author(s): 
Leung, Janice M.
Liu, Joseph C.
Mtambo, Andy
Ngan, David
Nashta, Negar
Guillemi, Silvia
Harris, Marianne
Lima, Viviane D.
Mattman, Andre
Shaipanich, Tawimas
Raju, Rekha
Hague, Cameron
Leipsic, Jonathon A.
Sin, Don D.
Montaner, Julio S.
Man, S. F. Paul
Publication Title: 
AIDS and behavior

To explore the role of informal caregivers in adherence, we compared adherence reports by caregivers to those of care recipients. We identified individual-level and relationship factors associated with agreement between caregivers' reports of recipients' adherence and assessed viral suppression. Participants were care recipients, who were on ART and had ever injected drugs, and their caregivers (N†=†258 dyads). Nearly three-fourths of caregivers' reports of recipients' ART adherence agreed with recipients' viral suppression status.

Author(s): 
Knowlton, Amy R.
Mitchell, Mary M.
Robinson, Allysha C.
Nguyen, Trang Q.
Isenberg, Sarina
Denison, Julie
Publication Title: 
Journal of Acquired Immune Deficiency Syndromes (1999)

BACKGROUND: Combination antiretroviral therapy (ART) for HIV-1-infected individuals prevents sexual transmission if viral load is suppressed. METHODS: Participants were HIV-1-infected partners randomized to early ART (CD4 350-550) in HPTN052 (n = 886, median follow-up = 2.1 years), a clinical trial of early ART to prevent sexual transmission of HIV-1 in serodiscordant couples at 13 sites in 9 countries. Adherence was assessed through pill count (dichotomized at <95%) and through self-report items.

Author(s): 
Safren, Steven A.
Mayer, Kenneth H.
Ou, San-San
McCauley, Marybeth
Grinsztejn, Beatriz
Hosseinipour, Mina C.
Kumarasamy, Nagalingeswaran
Gamble, Theresa
Hoffman, Irving
Celentano, David
Chen, Ying Qing
Cohen, Myron S.
HPTN 052 Study Team
Publication Title: 
Pain Medicine (Malden, Mass.)

OBJECTIVE: Painful HIV distal sensory polyneuropathy (HIV-DSP) is the most common nervous system disorder in HIV patients. The symptoms adversely affect patients' quality of life and often diminish their capacity for independent self-care. No interventions have been shown to be consistently effective in treating the disorder. The purpose of the present study was to determine whether hypnosis could be a useful intervention in the management of painful HIV-DSP. METHOD: Participants were 36 volunteers with HIV-DSP who received three weekly training sessions in self-hypnosis.

Author(s): 
Dorfman, David
George, Mary Catherine
Schnur, Julie
Simpson, David M.
Davidson, George
Montgomery, Guy
Publication Title: 
Journal of Vector Borne Diseases

BACKGROUND & OBJECTIVES: A prospective study on 72 HIV infected and 33 HIV negative individuals undergoing malaria treatment with dihydroartemisinin (Cotecxin) was undertaken to compare CD4 cells count, viral load and parasite density at two time-points, a baseline visit and a 9-day post-treatment visit. METHODS: CD4 count and viral load of the subjects were estimated using Dynabeads T4-T8 Quantification Protocol (Dyneal Biotech, Norway) and Amplicor HIV-1 Monitor Test respectively (Roche, United Kingdom).

Author(s): 
Tatfeng, Y. M.
Ihongbe, J. C.
Okodua, M.
Oviasogie, E.
Isibor, J.
Tchougang, S.
Tambo, E.
Otegbeye, T.
Publication Title: 
Antiviral Research

The anti-malaria drug artesunate has been shown to be an effective inhibitor of cytomegalovirus (CMV) in vitro, in an experimental animal model, and in a recent single-case clinical use. In this first case-series of 6 stem cell transplant recipients who received preemptive artesunate treatment for CMV infection, we have examined the viral kinetics following institution of artesunate, and employed first-phase viral kinetics studies to calculate its antiviral effectiveness.

Author(s): 
Wolf, Dana G.
Shimoni, Avichai
Resnick, Igor B.
Stamminger, Thomas
Neumann, Avidan U.
Chou, Sunwen
Efferth, Thomas
Caplan, Orit
Rose, Jessica
Nagler, Arnon
Marschall, Manfred
Publication Title: 
Journal of Stem Cells

The two neighboring southwestern states of India, Karnataka and Maharashtra, have high incidence of HIV/AIDS and are among the six most high prevalence HIV infected states. In Karnataka state, the northern districts of Bagalkot, Belgaum and Bijapur (the three Bs) and in Maharashtra state, the southern districts of Sangli, Satara, and Solapur (the three Ss) are the areas with the highest incidence of HIV/AIDS.

Author(s): 
Bhargav, Hemant
Huilgol, Vidya
Metri, Kashinath
Sundell, I. Birgitta
Tripathi, Satyam
Ramagouda, Nagaratna
Jadhav, Mahesh
Raghuram, Nagarathna
Ramarao, Nagendra Hongasandra
Koka, Prasad S.
Publication Title: 
AIDS patient care and STDs

The use of complementary and alternative medicine (CAM) therapies is widespread in many chronic illnesses, including human immunodeficiency virus (HIV) infection. The objective of this study was to determine the impact of increasingly effective antiretroviral therapy on the use of CAM in an HIV-positive patient population. A written survey was given to 191 HIV-positive outpatients. Participation was voluntary and anonymous. One hundred twenty-eight patients (67%) used CAM at some time to control HIV and 76 (40%) of the patients were currently using CAM.

Author(s): 
Duggan, J.
Peterson, W. S.
Schutz, M.
Khuder, S.
Charkraborty, J.
Publication Title: 
African journal of traditional, complementary, and alternative medicines: AJTCAM / African Networks on Ethnomedicines

Adherence to antiretroviral medication in the treatment of HIV is critical, both to maximize efficacy and to minimize the emergence of drug resistance. The aim of this prospective study in three public hospitals in KwaZulu-Natal, South Africa, is to assess the use of Traditional Complementary and Alternative Medicine (TCAM) by HIV patients and its effect on antiretroviral (ARV) adherence 6 months after initiating ARVs.

Author(s): 
Peltzer, Karl
Friend-du Preez, Natalie
Ramlagan, Shandir
Fomundam, Henry
Anderson, Jane

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