Virion

Publication Title: 
Molecular Cancer Therapeutics

Given the high fatality rate of pancreatic cancer, an effective treatment for this devastating disease is urgently needed. We have shown that mesothelin expression was higher in human pancreatic cancer cells than in human pancreatic duct epithelial cells, and mesothelin mRNA was substantially overexpressed in 18 of 21 (86%) clinical pancreatic adenocarcinoma specimens when compared with the surrounding normal tissues. However, the biological functions of mesothelin in tumor progression are not clearly understood.

Author(s): 
Li, Min
Bharadwaj, Uddalak
Zhang, Rongxin
Zhang, Sheng
Mu, Hong
Fisher, William E.
Brunicardi, F. Charles
Chen, Changyi
Yao, Qizhi
Publication Title: 
Virology Journal

BACKGROUND: Various members of the mint family have been used historically in Chinese and Native American medicine. Many of these same family members, including Prunella vulgaris, have been reported to have anti-viral activities. To further characterize the anti-lentiviral activities of P. vulgaris, water and ethanol extractions were tested for their ability to inhibit equine infectious anemia virus (EIAV) replication.

Author(s): 
Brindley, Melinda A.
Widrlechner, Mark P.
McCoy, Joe-Ann
Murphy, Patricia
Hauck, Cathy
Rizshsky, Ludmila
Nikolau, Basil
Maury, Wendy
Publication Title: 
Journal of Immunotherapy (Hagerstown, Md.: 1997)

Virus-like particles (VLPs) have gained increasing interest for their use as vaccines due to their repetitive antigenic structure that is capable of efficiently activating the immune system. The efficacy of VLP immunization may lie in its ability to traffic into draining lymph nodes while activating antigen-presenting cells to initiate the orchestration of signals required for the development of a robust immune response. Currently, there is no comprehensive study showing the correlation of different VLP vaccination routes to immune outcome.

Author(s): 
Cubas, Rafael
Zhang, Sheng
Kwon, Sunkuk
Sevick-Muraca, Eva M.
Li, Min
Chen, Changyi
Yao, Qizhi
Publication Title: 
Molecular Immunology

We have previously shown that immunization with SIV-, SHIV-, or HA (influenza hemagglutinin)-virus-like particles (VLPs) elicits a strong humoral immune response in mice. However, little is known about the action VLPs exert on immune effector cells, including B cells. In this study, we found that all three types of VLPs could directly bind and activate B cells in vitro. VLPs stimulated the proliferation of B220(+)IgM(+)CD43(-)CD5(-) B2 cells and their differentiation to plasma cells that preferentially produce IgG2a antibodies.

Author(s): 
Zhang, Sheng
Cubas, Rafael
Li, Min
Chen, Changyi
Yao, Qizhi
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