Virus Replication

Publication Title: 
Antiviral Research

Hot water extracts of four traditional herbs, Geum japonicum, Syzygium aromaticum, Terminalia chebula and Rhus javanica, which have been shown to have anti-herpes simplex virus (HSV) activity in vivo, were examined for anti-cytomegalovirus (CMV) activity in vitro and in vivo in this study. They inhibited replication of human CMV and murine CMV (MCMV) in vitro. These anti-CMV activities in vivo were examined in an MCMV infection model using immunosuppressed mice.

Author(s): 
Yukawa, T. A.
Kurokawa, M.
Sato, H.
Yoshida, Y.
Kageyama, S.
Hasegawa, T.
Namba, T.
Imakita, M.
Hozumi, T.
Shiraki, K.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Development of new and effective therapeutics for sexually transmitted herpes simplex virus-2 (HSV-2) infection is important from public health perspective. With an aim to identify natural products from medicinal plants, in the present study, the potential of Terminalia chebula Retz was investigated for its activity against HSV-2. METHODS: Fruits of Terminalia chebula Retz were used to prepare 50% ethanolic extract. In addition, chebulagic acid and chebulinic acid both purified from T. chebula were also used.

Author(s): 
Kesharwani, Ajay
Polachira, Suja Kizhiyedath
Nair, Reshmi
Agarwal, Aakanksha
Mishra, Nripendra Nath
Gupta, Satish Kumar
Publication Title: 
BMC cancer

BACKGROUND: Cancer is a significant and growing problem worldwide. While this increase may, in part, be attributed to increasing longevity, improved case notifications and risk-enhancing lifestyle (such as smoking, diet and obesity), hygiene-related factors resulting in immuno-regulatory failure may also play a major role and call for a revision of vaccination strategies to protect against a range of cancers in addition to infections. DISCUSSION: Human endogenous retroviruses (HERVs) are a significant component of a wider family of retroelements that constitutes part of the human genome.

Author(s): 
Cegolon, Luca
Salata, Cristiano
Weiderpass, Elisabete
Vineis, Paolo
Pal˘, Giorgio
Mastrangelo, Giuseppe
Publication Title: 
BMC cancer

BACKGROUND: Cancer is a significant and growing problem worldwide. While this increase may, in part, be attributed to increasing longevity, improved case notifications and risk-enhancing lifestyle (such as smoking, diet and obesity), hygiene-related factors resulting in immuno-regulatory failure may also play a major role and call for a revision of vaccination strategies to protect against a range of cancers in addition to infections. DISCUSSION: Human endogenous retroviruses (HERVs) are a significant component of a wider family of retroelements that constitutes part of the human genome.

Author(s): 
Cegolon, Luca
Salata, Cristiano
Weiderpass, Elisabete
Vineis, Paolo
Pal˘, Giorgio
Mastrangelo, Giuseppe
Publication Title: 
Journal of Molecular Biology
Author(s): 
Air, G. M.
Blackburn, E. H.
Coulson, A. R.
Galibert, F.
Sanger, F.
Sedat, J. W.
Ziff, E. B.
Publication Title: 
Journal of Molecular Biology
Author(s): 
Air, G. M.
Blackburn, E. H.
Coulson, A. R.
Galibert, F.
Sanger, F.
Sedat, J. W.
Ziff, E. B.
Publication Title: 
Journal of Interferon & Cytokine Research: The Official Journal of the International Society for Interferon and Cytokine Research

This review presents a personal overview of my interferon research. I relate the interests of my laboratory to the overall progress in the interferon field during the past 25 years. On behalf of the interferon community, I thank the Milstein family for their generosity and wisdom to recognize and honor basic research.

Author(s): 
Pitha, P. M.
Publication Title: 
Cancer Research

Nearly all cervical cancers are etiologically attributable to human papillomavirus (HPV) infection and pharmaceutical treatments targeting HPV-infected cells would be of great medical benefit. Because many neoplastic cells (including cervical cancer cells) overexpress the transferrin receptor to increase their iron uptake, we hypothesized that iron-dependent, antimalarial drugs such as artemisinin might prove useful in treating HPV-infected or transformed cells.

Author(s): 
Disbrow, Gary L.
Baege, Astrid C.
Kierpiec, Katie A.
Yuan, Hang
Centeno, Jose A.
Thibodeaux, Clare A.
Hartmann, Dan
Schlegel, Richard
Publication Title: 
PLoS neglected tropical diseases

BACKGROUND: An unexpectedly high seroprevalence and pathogenic potential of human parvovirus B19 (B19V) have been observed in certain malaria-endemic countries in parallel with local use of chloroquine (CQ) as first-line treatment for malaria. The aims of this study were to assess the effect of CQ and other common antimalarial drugs on B19V infection in vitro and the possible epidemiological consequences for children from Papua New Guinea (PNG).

Author(s): 
Bönsch, Claudia
Kempf, Christoph
Mueller, Ivo
Manning, Laurens
Laman, Moses
Davis, Timothy M. E.
Ros, Carlos
Publication Title: 
PloS One

BACKGROUND: Artesunate, an artemisinin-derived monomer, was reported to inhibit Cytomegalovirus (CMV) replication. We aimed to compare the in-vitro anti-CMV activity of several artemisinin-derived monomers and newly synthesized artemisinin dimers. METHODS: Four artemisinin monomers and two novel artemisinin-derived dimers were tested for anti-CMV activity in human fibroblasts infected with luciferase-tagged highly-passaged laboratory adapted strain (Towne), and a clinical CMV isolate. Compounds were evaluated for CMV inhibition and cytotoxicity.

Author(s): 
Arav-Boger, Ravit
He, Ran
Chiou, Chuang-Jiun
Liu, Jianyong
Woodard, Lauren
Rosenthal, Andrew
Jones-Brando, Lorraine
Forman, Michael
Posner, Gary

Pages

Subscribe to RSS - Virus Replication