Vitamin D

Publication Title: 
Climacteric: The Journal of the International Menopause Society

A number of health and lifestyle factors are thought to contribute to cognitive decline associated with age but cannot be easily modified by the individual patient. We identified 12 individually modifiable interventions that can be implemented during midlife or later with the potential to ameliorate cognitive aging. For ten of these, we used PubMed databases for a systematic review of long-duration (at least 6 months), randomized, controlled trials in midlife and older adults without dementia or mild cognitive impairment with objective measures of neuropsychological performance.

Author(s): 
Lehert, P.
Villaseca, P.
Hogervorst, E.
Maki, P. M.
Henderson, V. W.
Publication Title: 
Medicine

Otitis media (OM) has numerous presentations in children. Together with conventional medical therapies aimed to prevent and/or treat OM, a rising number of complementary and alternative medicine (CAM) treatment options can be offered. Since OM is common in children, parents may ask healthcare professionals about possible CAM therapies. Many physicians feel that their knowledge is limited regarding these therapies, and that they desire some information.

Author(s): 
Marom, Tal
Marchisio, Paola
Tamir, Sharon Ovnat
Torretta, Sara
Gavriel, Haim
Esposito, Susanna
Publication Title: 
Clinical and Experimental Dermatology

This review provides a summary of key findings from 22 systematic reviews on atopic eczema (AE) published over the 2-year period from January 2012 to 31 December 2013, focusing on prevention and treatment of AE. For an update of systematic reviews on the epidemiology, mechanisms of disease and methodological issues, see Part 1 of this update. Based on current systematic review evidence, the most promising intervention for the prevention of AE is the use of probiotics (and possibly prebiotics) during the late stages of pregnancy and early life.

Author(s): 
Madhok, V.
Futamura, M.
Thomas, K. S.
Barbarot, S.
Publication Title: 
Medicine

Otitis media (OM) has numerous presentations in children. Together with conventional medical therapies aimed to prevent and/or treat OM, a rising number of complementary and alternative medicine (CAM) treatment options can be offered. Since OM is common in children, parents may ask healthcare professionals about possible CAM therapies. Many physicians feel that their knowledge is limited regarding these therapies, and that they desire some information.

Author(s): 
Marom, Tal
Marchisio, Paola
Tamir, Sharon Ovnat
Torretta, Sara
Gavriel, Haim
Esposito, Susanna
Publication Title: 
Journal of Nutritional Science and Vitaminology

Calcium deficiency is a constant menace to land-abiding animals, including mammals. Humans enjoying exceptional longevity on earth are especially susceptible to calcium deficiency in old age.

Author(s): 
Fujita, T.
Publication Title: 
Postgraduate Medicine

Vascular calcification (VC), commonly encountered in renal failure, diabetes, and aging, is associated with a large increase in the risk for cardiovascular events and mortality. Calcification of the arterial media and of heart valves clearly plays a mediating role in this regard, whereas it is less clear how calcification of plaque influences atherogenesis and risk for plaque rupture. Vascular calcification is an active process in which vascular smooth muscle cells (VSMCs) adopt an osteoblastic phenotype and deposit hydroxyapatite crystals; apoptosis of VSMCs also promotes this deposition.

Author(s): 
McCarty, Mark F.
DiNicolantonio, James J.
Publication Title: 
Journal of Nutritional Science and Vitaminology

Calcium deficiency is a constant menace to land-abiding animals, including mammals. Humans enjoying exceptional longevity on earth are especially susceptible to calcium deficiency in old age.

Author(s): 
Fujita, T.
Publication Title: 
Annual Review of Nutrition

Increased longevity and improved medical management of children with chronic illnesses has led to a focus on the short- and long-term consequences of these conditions on bone health. Bone loss is influenced by diet, malabsorption, and disease-related imbalances in bone turnover. It may be exacerbated by common medications, especially corticosteroids.

Author(s): 
Abrams, S. A.
O'Brien, K. O.
Publication Title: 
Current Opinion in Pulmonary Medicine

PURPOSE OF REVIEW: As individuals with cystic fibrosis (CF) have experienced marked improvements in longevity over the last three decades, bone disease has emerged as a new problem. Bone disease in CF has not been previously reviewed in this journal. Therefore, this review will give a brief overview of bone disease in CF and then concentrate on treatment options. RECENT FINDINGS: In some series, as many as three fourths of adults with CF have low bone density.

Author(s): 
Aris, Robert
Lester, Gayle
Ontjes, David
Publication Title: 
Experimental Gerontology

Skeletal remodelling is a continuous process during life and is still active also in extreme senescence. In the elderly, bone resorption often prevails over bone formation, causing bone loss and fragility. Elderly subjects are exposed to the risk of fractures, and loss of self-sufficiency, if considering that the proximal femur is the most frequently involved site. Bone remodelling can maintain circulating calcium within physiological ranges, at the expense of a substantial loss of this ion from the skeleton, particularly during senescence.

Author(s): 
Passeri, Giovanni
Vescovini, Rosanna
Sansoni, Paolo
Galli, Carlo
Franceschi, Claudio
Passeri, Mario
Italian Multicentric Study on Centenarians (IMUSCE)

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