Vitamin K

Publication Title: 
The Journal of Cardiovascular Nursing

The formation of blood clots is a significant threat to individuals with limited mobility, whether in the hospital or recovering in an outpatient setting. Prevention of deep vein thrombosis and pulmonary embolism has been found to be cost-effective when compared with treating an existing thrombosis. Despite these positive findings, compliance with the clinical practice guidelines is less than ideal.

Author(s): 
Long, Janet B.
Publication Title: 
Postgraduate Medicine

Vascular calcification (VC), commonly encountered in renal failure, diabetes, and aging, is associated with a large increase in the risk for cardiovascular events and mortality. Calcification of the arterial media and of heart valves clearly plays a mediating role in this regard, whereas it is less clear how calcification of plaque influences atherogenesis and risk for plaque rupture. Vascular calcification is an active process in which vascular smooth muscle cells (VSMCs) adopt an osteoblastic phenotype and deposit hydroxyapatite crystals; apoptosis of VSMCs also promotes this deposition.

Author(s): 
McCarty, Mark F.
DiNicolantonio, James J.
Publication Title: 
Cancer Research

Apurinic/apyrimidinic endonuclease is a key enzyme in the process of base excision repair, required for the repair of spontaneous base damage that arises as a result of oxidative damage to DNA. In mice, this endonuclease is coded by the Apex gene, disruption of which is incompatible with embryonic life. Here we confirm the embryonic lethality of Apex-null mice and report the phenotypic characterization of mice that are heterozygous mutants for the Apex gene (Apex+/-). We show that Apex heterozygous mutant cells and animals are abnormally sensitive to increased oxidative stress.

Author(s): 
Meira, L. B.
Devaraj, S.
Kisby, G. E.
Burns, D. K.
Daniel, R. L.
Hammer, R. E.
Grundy, S.
Jialal, I.
Friedberg, E. C.
Publication Title: 
Theoretical Biology & Medical Modelling

BACKGROUND: Both prophylaxis and treatment of venous thromboembolism (VTE: deep venous thrombosis (DVT) and pulmonary emboli (PE)) with anticoagulants are associated with significant risks of major and fatal hemorrhage. Anticoagulation treatment of VTE has been the standard of care in the USA since before 1962 when the U.S. Food and Drug Administration began requiring randomized controlled clinical trials (RCTs) showing efficacy, so efficacy trials were never required for FDA approval.

Author(s): 
Cundiff, David K.
Agutter, Paul S.
Malone, P. Colm
Pezzullo, John C.
Publication Title: 
The American Journal of Clinical Nutrition

BACKGROUND: For children and adolescents with cystic fibrosis (CF) and pancreatic insufficiency, the efficacy of routine vitamin K supplementation to normalize vitamin K status remains unclear. OBJECTIVE: This study examined and determined predictors of vitamin K status in subjects aged 8-25 y with CF and pancreatic insufficiency taking various vitamin K supplements.

Author(s): 
Dougherty, Kelly A.
Schall, Joan I.
Stallings, Virginia A.
Publication Title: 
The American Journal of Clinical Nutrition

BACKGROUND: For children and adolescents with cystic fibrosis (CF) and pancreatic insufficiency, the efficacy of routine vitamin K supplementation to normalize vitamin K status remains unclear. OBJECTIVE: This study examined and determined predictors of vitamin K status in subjects aged 8-25 y with CF and pancreatic insufficiency taking various vitamin K supplements.

Author(s): 
Dougherty, Kelly A.
Schall, Joan I.
Stallings, Virginia A.
Publication Title: 
MedGenMed: Medscape General Medicine

CONTEXT: Vitamin K acupuncture point injection, a menstrual pain treatment derived from traditional Chinese medicine, has been a standard treatment in some hospitals in China since the 1980s. OBJECTIVES: To investigate the effects of vitamin K acupuncture point injection on menstrual pain in young women aged 14 to 25 from different countries and cultural backgrounds who have had unmitigated severe primary dysmenorrhea for 6 months or more.

Author(s): 
Wang, Li
Cardini, Francesco
Zhao, Wenjie
Regalia, Anna Laura
Wade, Christine
Forcella, Emanuela
Yu, Jin
Publication Title: 
MedGenMed: Medscape General Medicine

CONTEXT: Vitamin K acupuncture point injection, a menstrual pain treatment derived from traditional Chinese medicine, has been a standard treatment in some hospitals in China since the 1980s. OBJECTIVES: To investigate the effects of vitamin K acupuncture point injection on menstrual pain in young women aged 14 to 25 from different countries and cultural backgrounds who have had unmitigated severe primary dysmenorrhea for 6 months or more.

Author(s): 
Wang, Li
Cardini, Francesco
Zhao, Wenjie
Regalia, Anna Laura
Wade, Christine
Forcella, Emanuela
Yu, Jin
Publication Title: 
Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan / Sponsored by All-China Association of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine
Author(s): 
Wang, Wei
Zhang, Jingyun
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