Vitis

Publication Title: 
Rejuvenation Research

A botanical extract (Regrapex-R) prepared from whole grape (Vitis vinifera) and Polygonum cuspidatum, which contains polyphenols, including flavans, anthocyanins, emodin, and resveratrol, exhibited dose-dependent scavenging effects on reactive oxygen species (ROS). The extract inhibited increases of ROS and protein carbonyl in isolated rat liver mitochondria following exposure to 2,2'-azobis (2-amidino propane) dihydrocholoride (AAPH), a potent lipid oxidant generator.

Author(s): 
Long, Jiangang
Gao, Hongxiang
Sun, Lijuan
Liu, Jiankang
Zhao-Wilson, Xi
Publication Title: 
Science (New York, N.Y.)
Author(s): 
Hall, Stephen S.
Publication Title: 
PloS One

The "organic food" market is the fastest growing food sector, yet it is unclear whether organically raised food is nutritionally superior to conventionally grown food and whether consuming organic food bestows health benefits. In order to evaluate potential health benefits of organic foods, we used the well-characterized fruit fly Drosophila melanogaster as a model system. Fruit flies were raised on a diets consisting of extracts of either conventionally or organically raised produce (bananas, potatoes, raisins, soy beans).

Author(s): 
Chhabra, Ria
Kolli, Santharam
Bauer, Johannes H.
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

OBJECTIVES: Two controlled trials of aromatherapy to decrease agitation in persons with dementia have recently produced promising results. However, both studies combined the use of essential oils with massage. Thus, it is unclear if the effect of the aromatherapy intervention was the result of smelling or the cutaneous absorption of the oils. The purpose of this study was to determine whether smelling lavender oil decreases the frequency of agitated behaviors in patients with dementia.

Author(s): 
Snow, Lynn A.
Hovanec, Linda
Brandt, Jason
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: The aerial parts of Vitis vinifera (common grape or European grape) have been widely used in Ayurveda to treat a variety of common and stress related disorders. In the present investigation, the seed extract of V. vinifera was evaluated for antistress activity in normal and stress induced rats. Furthermore, the extract was studied for nootropic activity in rats and in-vitro antioxidant potential to correlate its antistress activity.

Author(s): 
Sreemantula, Satyanarayana
Nammi, Srinivas
Kolanukonda, Rajabhanu
Koppula, Sushruta
Boini, Krishna M.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: The aerial parts of Vitis vinifera (common grape or European grape) have been widely used in Ayurveda to treat a variety of common and stress related disorders. In the present investigation, the seed extract of V. vinifera was evaluated for antistress activity in normal and stress induced rats. Furthermore, the extract was studied for nootropic activity in rats and in-vitro antioxidant potential to correlate its antistress activity.

Author(s): 
Sreemantula, Satyanarayana
Nammi, Srinivas
Kolanukonda, Rajabhanu
Koppula, Sushruta
Boini, Krishna M.
Publication Title: 
The American Journal of Clinical Nutrition

BACKGROUND: Concord grape juice (CGJ) is a rich source of flavonoids, which have greater antioxidant efficacy in vitro than does alpha-tocopherol; however, the efficacies of flavonoids and alpha-tocopherol in vivo have not been compared. OBJECTIVE: We compared the in vivo antioxidant efficacy of CGJ with that of alpha-tocopherol in healthy adults. DESIGN: Subjects were randomly assigned to receive either 400 IU RRR-alpha-tocopherol/d (n = 17) or 10 mL CGJ. kg(-1). d(-1) (n = 15) for 2 wk.

Author(s): 
O'Byrne, Dawn J.
Devaraj, Sridevi
Grundy, Scott M.
Jialal, Ishwarlal
Publication Title: 
Cancer Research

In breast cancer, in situ estrogen production has been demonstrated to play a major role in promoting tumor growth. Aromatase is the enzyme responsible for the conversion of androgen substrates into estrogens. This enzyme is highly expressed in breast cancer tissue compared with normal breast tissue. A wine extract fraction was recently isolated from red wine that exhibited a potent inhibitory action on aromatase activity.

Author(s): 
Eng, Elizabeth T.
Ye, JingJing
Williams, Dudley
Phung, Sheryl
Moore, Roger E.
Young, Mary K.
Gruntmanis, Ugis
Braunstein, Glenn
Chen, Shiuan
Publication Title: 
The Journal of Nutrition

Many popular dietary supplements are enriched in polyphenols such as the soy isoflavones, tea catechins, and resveratrol (from grape skins), each of which has been shown to have chemopreventive activity in cellular models of cancer. The proanthocyanidins, which are oligomers of the catechins, are enriched in grape seeds and form the basis of the dietary supplement grape seed extract (GSE). Evidence suggests that the proanthocyanidins may be metabolized to the monomeric catechins.

Author(s): 
Kim, Helen
Hall, Patti
Smith, Michelle
Kirk, Marion
Prasain, Jeevan K.
Barnes, Stephen
Grubbs, Clinton
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

BACKGROUND: Grape-seed (Vitis spp.) extract (GSE) is a widely used antioxidant dietary supplement. Chemotherapeutic agents such as cisplatin induce oxidative damage in the gastrointestinal tract and cause nausea and vomiting. MATERIALS AND METHODS: A rat model of simulated emesis was used to observe that cisplatin significantly increased kaolin consumption (or pica). Three GSEs from different sources were used in this study.

Author(s): 
Wang, Chong-Zhi
Fishbein, Anna
Aung, Han H.
Mehendale, Sangeeta R.
Chang, Wei-Tien
Xie, Jing-Tian
Li, Jing
Yuan, Chun-Su

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