Publication Title: 
Heart (British Cardiac Society)
Broustet, J. P.
Publication Title: 

In diverse organisms, calorie restriction slows the pace of ageing and increases maximum lifespan. In the budding yeast Saccharomyces cerevisiae, calorie restriction extends lifespan by increasing the activity of Sir2 (ref. 1), a member of the conserved sirtuin family of NAD(+)-dependent protein deacetylases. Included in this family are SIR-2.1, a Caenorhabditis elegans enzyme that regulates lifespan, and SIRT1, a human deacetylase that promotes cell survival by negatively regulating the p53 tumour suppressor.

Howitz, Konrad T.
Bitterman, Kevin J.
Cohen, Haim Y.
Lamming, Dudley W.
Lavu, Siva
Wood, Jason G.
Zipkin, Robert E.
Chung, Phuong
Kisielewski, Anne
Zhang, Li-Li
Scherer, Brandy
Sinclair, David A.
Publication Title: 
Science (New York, N.Y.)
Hall, Stephen S.
Publication Title: 
Finkel, Toren
Publication Title: 
Corder, Roger
Crozier, Alan
Kroon, Paul A.
Publication Title: 
European journal of cancer prevention: the official journal of the European Cancer Prevention Organisation (ECP)

While several investigations have focused on the association between individual foods and nutrients upon the development of chronic diseases, few have examined the role that entire dietary patterns may play in health and disease. A dietary pattern generally considered to have beneficial health effects is that of the Mediterranean diet. In this paper, five cohort studies exploring the association of Mediterranean diet with overall mortality and hence longevity are reviewed. A number of conclusions can be drawn.

Trichopoulou, A.
Critselis, E.
Publication Title: 
The American Journal of Clinical Nutrition

BACKGROUND: The need to gain insight into prevailing eating patterns and their health effects is evident. OBJECTIVE: This study aimed to identify dietary patterns and their relation to total mortality in older Dutch women. DESIGN: A principal component analysis of 22 food groups was used to identify dietary patterns in 5427 women aged 60-69 y who were included in the Dutch European Prospective Investigation into Cancer and Nutrition-Elderly cohort (follow-up: approximately 8.2 y). Mortality ratios for 3 major principal components were assessed by using Cox proportional hazard analysis.

Waijers, Patricia M. C. M.
Ocké, Marga C.
van Rossum, Caroline T. M.
Peeters, Petra H. M.
Bamia, Christina
Chloptsios, Yiannis
van der Schouw, Yvonne T.
Slimani, Nadia
Bueno-de-Mesquita, H. Bas
Publication Title: 
MÈdecine Sciences: M/S
Labie, Dominique
FerrÈ, Pascal
Publication Title: 
Metabolic Syndrome and Related Disorders

Several experimental studies and some clinical experience have shown that metabolic syndrome and caloric restriction exert opposite effects on thrombosis, because these two nourishing conditions are at extreme ends of the same spectrum. The antithrombotic action induced by caloric restriction happens through Sirtuin 1 (SIRT1), a gene/protein activated by the reduction of calorie intake lower than is typical. The antithrombotic effect is due to the activation of SIRT1 acting through an increase of insulin sensitivity, which reduces endothelial dysfunction.

Cacciapuoti, Federico
Publication Title: 
European journal of cancer prevention: the official journal of the European Cancer Prevention Organisation (ECP)

In the coming years, European death rates because of cancer will further decline, but the overall number of cases will increase, mostly as a consequence of the ageing of the population. The target for cancer prevention in Europe will remain a healthy diet and control of obesity in addition to a decrease in smoking. A healthy diet model in European countries is the traditional Mediterranean diet, which is based on abundant and variable plant foods, high consumption of cereals, olive oil as the main (added) fat, low intake of (red) meat and moderate consumption of wine.

Giacosa, Attilio
Barale, Roberto
Bavaresco, Luigi
Gatenby, Piers
Gerbi, Vincenzo
Janssens, Jaak
Johnston, Belinda
Kas, Koen
La Vecchia, Carlo
Mainguet, Paul
Morazzoni, Paolo
Negri, Eva
Pelucchi, Claudio
Pezzotti, Mario
Rondanelli, Mariangela


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