Withania

Publication Title: 
The Journal of Pharmacy and Pharmacology

OBJECTIVES: Withania somnifera has been in use for several thousand years in Ayurveda to treat various neurological disorders. There is, however, not much scientific data on its protective role in neuronal pathology specifically against brain oxidative stress. Hence, an attempt is made in this work for systematic review and meta-analysis of W. somnifera on neurobehavioural disorders induced by brain oxidative stress in rodents. METHODS: A systematic search of the effect of W. somnifera on brain oxidative stress-induced neuronal pathology was performed using electronic databases.

Author(s): 
Durg, Sharanbasappa
Dhadde, Shivsharan B.
Vandal, Ravichandra
Shivakumar, Badamaranahalli S.
Charan, Chabbanahalli S.
Publication Title: 
Recent patents on CNS drug discovery

BACKGROUND: Owing to the increasing aged population globally, disorders and diseases of the CNS are anticipated to increase and profoundly impact the health care. As these neurodegenerative diseases (NDD) are complex, multifactorial and do not have identified etiological factors, unfortunately, drugs developed for the purpose have not met with the expected success. Hence, there has been a constant demand for the development of natural therapeutic adjuvants which are safe and possess the potential to attenuate multiple pathways.

Author(s): 
Yenisetti, Sarat C.
Manjunath, M. J.
Muralidhara, C.
Publication Title: 
Alternative Medicine Review: A Journal of Clinical Therapeutic

OBJECTIVE: The objective of this paper is to review the literature regarding Withania somnifera (ashwagandha, WS) a commonly used herb in Ayurvedic medicine. Specifically, the literature was reviewed for articles pertaining to chemical properties, therapeutic benefits, and toxicity.

Author(s): 
Mishra, L. C.
Singh, B. B.
Dagenais, S.
Publication Title: 
Alternative Medicine Review: A Journal of Clinical Therapeutic

OBJECTIVE: The objective of this paper is to review the literature regarding Withania somnifera (ashwagandha, WS) a commonly used herb in Ayurvedic medicine. Specifically, the literature was reviewed for articles pertaining to chemical properties, therapeutic benefits, and toxicity.

Author(s): 
Mishra, L. C.
Singh, B. B.
Dagenais, S.
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

OBJECTIVE: Isolation of biologically active fractions and compounds from the roots of Withania somnifera, a plant used extensively as a constituent of rasayana, in Ayurveda and to test their adaptogenic activity on stress indices using the cold-hypoxia-restraint (C-H-R) model. DESIGN: Bioactivity-guided fractionation of an aqueous extract of the roots of Withania somnifera led to the isolation of a new species of withanolide 1-oxo-5beta, 6beta-epoxy-witha-2-ene-27-ethoxy-olide.

Author(s): 
Kaur, Parvinder
Sharma, Meenakshi
Mathur, Sheenu
Tiwari, Manisha
Divekar, Harish M.
Kumar, Ratan
Srivastava, Kaushal K.
Chandra, Ramesh
Publication Title: 
Molecular Cancer Therapeutics

The plant Withania somnifera Dunal (Ashwagandha), also known as Indian ginseng, is widely used in the Ayurvedic system of medicine to treat tumors, inflammation, arthritis, asthma, and hypertension. Chemical investigation of the roots and leaves of this plant has yielded bioactive withanolides. Earlier studies showed that withanolides inhibit cyclooxygenase enzymes, lipid peroxidation, and proliferation of tumor cells.

Author(s): 
Ichikawa, Haruyo
Takada, Yasunari
Shishodia, Shishir
Jayaprakasam, Bolleddula
Nair, Muraleedharan G.
Aggarwal, Bharat B.
Publication Title: 
Alternative Medicine Review: A Journal of Clinical Therapeutic

Withania somnifera Dunal, commonly known as ashwagandha, has been used for centuries in Ayurvedic medicine to increase longevity and vitality. Western research supports its polypharmaceutical use, confirming antioxidant, anti-inflammatory, immune-modulating, and antistress properties in the whole plant extract and several separate constituents. This article reviews the literature pertaining to Withania somnifera and its botanical constituents as antitumor agents and in conjunction with radiation and chemotherapy treatment.

Author(s): 
Winters, Marie
Publication Title: 
Clinical Cancer Research: An Official Journal of the American Association for Cancer Research

PURPOSE: Ashwagandha is regarded as a wonder shrub of India and is commonly used in Ayurvedic medicine and health tonics that claim its variety of health-promoting effects. Surprisingly, these claims are not well supported by adequate studies, and the molecular mechanisms of its action remain largely unexplored to date. We undertook a study to identify and characterize the antitumor activity of the leaf extract of ashwagandha.

Author(s): 
Widodo, Nashi
Kaur, Kamaljit
Shrestha, Bhupal G.
Takagi, Yasuomi
Ishii, Tetsuro
Wadhwa, Renu
Kaul, Sunil C.
Publication Title: 
Chemical & Pharmaceutical Bulletin

Multiple shoot cultures of two experimental lines of Withania somnifera plants (RS-Selection-1 and RS-Selection-2) were established using nodal segments as explants. The hormonal combinations of benzyl adenine and kinetin not only influenced their morphogenetic response but also differentially modulated the level of biogeneration of withanolide A in the in vitro shoots of the two lines. Interestingly, withanolide-A, that was hardly detectable in the aerial parts of field-grown Withania somnifera (explant source), accumulated considerably in the in vitro shoot cultures of the plant.

Author(s): 
Sangwan, Rajender Singh
Chaurasiya, Narayan Das
Lal, Payare
Misra, Laxminarain
Uniyal, Girish Chandra
Tuli, Rakesh
Sangwan, Neelam Singh
Publication Title: 
Journal of Translational Medicine

Ayurveda is one of the ancient systems of health care of Indian origin. Roughly translated into "Knowledge of life", it is based on the use of natural herbs and herb products for therapeutic measures to boost physical, mental, social and spiritual harmony and improve quality of life. Although sheltered with long history and high trust, ayurveda principles have not entered laboratories and only a handful of studies have identified pure components and molecular pathways for its life-enhancing effects.

Author(s): 
Deocaris, Custer C.
Widodo, Nashi
Wadhwa, Renu
Kaul, Sunil C.

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