X-Ray Diffraction

Publication Title: 
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy

Biologically inspired experimental process in synthesising nanoparticles is of great interest in present scenario. Biosynthesis of nanoparticles is considered to be one of the best green techniques in synthesising metal nanoparticles. Here, an in situ green biogenic synthesis of gold nanoparticles using aqueous extracts of Terminalia chebula as reducing and stabilizing agent is reported. Gold nanoparticles were confirmed by surface plasmon resonance in the range of 535 nm using UV-visible spectrometry.

Author(s): 
Kumar, Kesarla Mohan
Mandal, Badal Kumar
Sinha, Madhulika
Krishnakumar, Varadhan
Publication Title: 
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy

A green rapid biogenic synthesis of silver nanoparticles (Ag NPs) using Terminalia chebula (T. chebula) aqueous extract was demonstrated in this present study. The formation of silver nanoparticles was confirmed by Surface Plasmon Resonance (SPR) at 452 nm using UV-visible spectrophotometer. The reduction of silver ions to silver nanoparticles by T. chebula extract was completed within 20 min which was evidenced potentiometrically.

Author(s): 
Mohan Kumar, Kesarla
Sinha, Madhulika
Mandal, Badal Kumar
Ghosh, Asit Ranjan
Siva Kumar, Koppala
Sreedhara Reddy, Pamanji
Publication Title: 
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy

A green one step facile synthesis of graphene nanosheets by Terminalia chebula (T. chebula) extract mediated reduction of graphite oxide (GO) is reported in this work. This method avoids the use of harmful toxic reducing agents. The comparative results of various characterizations of GO and T. chebula reduced graphene oxide (TCG) provide a strong indication of the exclusion of oxygen containing groups from graphene oxide and successive stabilization of the formed reduced graphene oxide (RGO).

Author(s): 
Maddinedi, Sireesh Babu
Mandal, Badal Kumar
Vankayala, Raviraj
Kalluru, Poliraju
Pamanji, Sreedhara Reddy
Publication Title: 
Journal of Toxicology and Environmental Health. Part A

The use of dietary adsorbents to reduce arsenic (As) exposure is innovative. Ferrihydrite successfully sorbs arsenite and asenate over a wide range of pH conditions and the As-ferrihydrite complexes are stable in gastrointestinal (GIT) models.

Author(s): 
Taylor, John F.
Robinson, Abraham
Mitchell, Nicole J.
Marroquin-Cardona, Alicia
Johnson, Natalie
Elmore, Sarah E.
Romoser, Amelia A.
Phillips, Timothy D.
Publication Title: 
Ayu

Tamra Bhasma (incinerated copper) is one of the main weapons in the archery of Ayurvedic practitioners. Though several methods of preparation of Tamra Bhasma (TB) are found in Rasashastra classics, several difficulties occur during the preparation of a good-quality Bhasma. In this study, TB was prepared and analyzed to develop the standard manufacturing procedure. Each unit operative procedure was considered as an independent processing and an attempt was made to validate each procedure. Wire used for the purpose of electrical earthing was taken for the preparation of Bhasma.

Author(s): 
Jagtap, Chandrashekhar Y.
Prajapati, Pradeep Kumar
Patgiri, Biswajyoti
Shukla, Vinay J.
Publication Title: 
Archiv Der Pharmazie

Conveniently accessible 4-[(2-(3,4-dimethoxyphenyl)ethyl]-3-thiosemicarbazide (2) was converted to new 1-substituted benzylidene/furfurylidene-4- [2-(3,4-dimethoxyphenyl)ethyl]-3-thiosemicarbazides (3) which furnished 2-(substituted benzylidene/furfurylidene) hydrazono-3-[2-(3,4-dimethoxyphenyl)ethyl]thiazolidin-4-ones (4) and 1-(substituted benzylidene/furfurylidene)-amino -3-[2-(3,4-dimethoxyphenyl)ethyl]-2-thioxo-4,5-imidazolidinedio nes (5) on reaction with chloroacetic acid and oxalyl chloride, respectively.

Author(s): 
Ergenç, N.
Capan, G.
Günay, N. S.
Ozkirimli, S.
Güngör, M.
Ozbey, S.
Kendi, E.
Publication Title: 
AAPS PharmSciTech

The purpose of this research was to mask the intensely bitter taste of artemether (ARM) and to formulate a rapid-disintegrating tablet (RDT) of the taste-masked drug. Taste masking was done by solid dispersion with mono amino glycyrrhyzinate pentahydrate (GLY) by solvent evaporation method. To characterize and formulate taste masked rapid disintegrating tablets (RDTs) of ARM, the 1:1M solid dispersion was selected based on bitterness score.

Author(s): 
Shah, Punit P.
Mashru, Rajashree C.
Publication Title: 
Chemical & Pharmaceutical Bulletin

The main objective of this research is to improve the dissolution rate of artemisinin (ART) by fabrication with ?-cyclodextrin (?-CD) as a hydrophilic carrier. Artemisinin nanoparticles and ART/?-CD complexes were successfully fabricated by means of evaporative precipitation of nanosuspension. Characterization of the samples was done by scanning electron microscopy (SEM), Fourier transform infrared (FT-IR), X-ray diffraction (XRD), differential scanning calorimetry (DSC) and dissolution tester.

Author(s): 
Kakran, Mitali
Sahoo, Nanda Gopal
Li, Lin
Judeh, Zaher
Publication Title: 
International Journal of Molecular Sciences

The particle sizes of pharmaceutical substances are important for their bioavailability. Bioavailability can be improved by reducing the particle size of the drug. In this study, artemisinin was micronized by the rapid expansion of supercritical solutions (RESS). The particle size of the unprocessed white needle-like artemisinin particles was 30 to 1200 ?m. The optimum micronization conditions are determined as follows: extraction temperature of 62 °C, extraction pressure of 25 MPa, precipitation temperature 45 °C and nozzle diameter of 1000 ?m.

Author(s): 
Yu, Huimin
Zhao, Xiuhua
Zu, Yuangang
Zhang, Xinjuan
Zu, Baishi
Zhang, Xiaonan
Publication Title: 
PloS One

BACKGROUND: Hemozoin crystals are normally formed in vivo by Plasmodium parasites to detoxify free heme released after hemoglobin digestion during its intraerythrocytic stage. Inhibition of hemozoin formation by various drugs results in free heme concentration toxic for the parasites. As a consequence, in vitro assays have been developed to screen and select candidate antimalarial drugs based on their capacity to inhibit hemozoin formation.

Author(s): 
Thomas, Vincent
Góis, Ana
Ritts, Bruce
Burke, Peter
Hänscheid, Thomas
McDonnell, Gerald

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