Xerostomia

Publication Title: 
Journal of Oral Rehabilitation

The aim of this systematic review was to assess the efficacy of acupuncture in the management of xerostomia. Assessing quality of studies aim to efficiently integrate valid information and provide a basis for sound decision making based on the best available evidence. Articles of controlled clinical trials evaluating the efficacy of acupuncture in the management of xerostomia were obtained by searching through the databases MEDLINE and Cochrane Central Register of Controlled Trials to September 2003.

Author(s): 
Jedel, E.
Publication Title: 
Journal of the Society for Integrative Oncology

Acupuncture has been evaluated in clinical studies for its effect in reducing some of the common symptoms experienced by cancer patients. Here we introduce this ancient treatment modality, outline its practice in the modern Western medicine setting, discuss safety issues related to the general and oncology populations , discuss its clinical applications in treating common symptoms experienced by cancer patients, and summarize data from clinical studies related to these applications .

Author(s): 
Deng, Gary
Vickers, Andrew
Simon Yeung, K.
Cassileth, Barrie R.
Publication Title: 
Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer

PURPOSE: This systematic review aimed to assess the literature for management strategies and economic impact of salivary gland hypofunction and xerostomia induced by cancer therapies and to determine the quality of evidence-based management recommendations. METHODS: The electronic databases of MEDLINE/PubMed and EMBASE were searched for articles published in English since the 1989 NIH Development Consensus Conference on the Oral Complications of Cancer Therapies until 2008 inclusive.

Author(s): 
Jensen, S. B.
Pedersen, A. M. L.
Vissink, A.
Andersen, E.
Brown, C. G.
Davies, A. N.
Dutilh, J.
Fulton, J. S.
Jankovic, L.
Lopes, N. N. F.
Mello, A. L. S.
Muniz, L. V.
Murdoch-Kinch, C. A.
Nair, R. G.
Napeñas, J. J.
Nogueira-Rodrigues, A.
Saunders, D.
Stirling, B.
von Bültzingslöwen, I.
Weikel, D. S.
Elting, L. S.
Spijkervet, F. K. L.
Brennan, M. T.
Salivary Gland Hypofunction/Xerostomia Section
Oral Care Study Group
Multinational Association of Supportive Care in Cancer (MASCC)/International Society of Oral Oncology (ISOO)
Publication Title: 
Acupuncture in Medicine: Journal of the British Medical Acupuncture Society

BACKGROUND: Irradiation-induced xerostomia seriously reduces quality of life for patients with head and neck cancer (HNC). Anecdotal evidence suggests that acupuncture may be beneficial. OBJECTIVE: To systematically review evidence on clinical effectiveness and safety of acupuncture in irradiation-induced xerostomia in patients with HNC. METHODS: A detailed search was performed to identify randomised controlled trials (RCTs) and systematic reviews of RCTs on acupuncture in irradiation-induced xerostomia, using AMED, BNIA, CINAHL, Cochrane, Embase, HPSI, PsycInfo and Medline.

Author(s): 
O'Sullivan, E. M.
Higginson, I. J.
Publication Title: 
Integrative Cancer Therapies

BACKGROUND: Methods currently available to prevent and manage xerostomia which caused by radiotherapy in patients with head and neck caner have limited efficacy. Some studies suggest that acupuncture may be beneficial. OBJECTIVES: The authors evaluated the preventive and therapeutic effect of acupuncture for radiation-induced xerostomia among patients with head and neck cancer.

Author(s): 
Zhuang, Liping
Yang, Zongguo
Zeng, Xiantao
Zhua, Xiaoyan
Chen, Zhen
Liu, Luming
Meng, Zhiqiang
Publication Title: 
The Cochrane Database of Systematic Reviews

BACKGROUND: Xerostomia is the subjective sensation of dry mouth. Common causes of xerostomia include adverse effects of many commonly prescribed medications, disease (e.g. Sjogren's Syndrome) and radiotherapy treatment for head and neck cancers. Non-pharmacological techniques such as acupuncture or mild electrostimulation may be used to improve symptoms. OBJECTIVES: To assess the effects of non-pharmacological interventions administered to stimulate saliva production for the relief of dry mouth.

Author(s): 
Furness, Susan
Bryan, Gemma
McMillan, Roddy
Birchenough, Sarah
Worthington, Helen V.
Publication Title: 
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

OBJECTIVE: To analyze the efficacy of various treatment options for radiation-induced hyposalivation in patients with head and neck cancer. STUDY DESIGN: A literature review and meta-analysis was performed on all appropriate literature identified via MEDLINE/PubMed. RESULTS: Fourteen articles were identified that met inclusion criteria for review, and 8 articles qualified for inclusion in the meta-analysis.

Author(s): 
Lovelace, Tiffany L.
Fox, Nyssa F.
Sood, Amit J.
Nguyen, Shaun A.
Day, Terry A.
Publication Title: 
Evidence-Based Dentistry

DATA SOURCES: The Cochrane Oral Health Group's Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Medline, Embase, AMED, CINAHL and CANCERLIT databases were searched. The metaRegister of Controlled Clinical Trials and ClinicalTrials.gov were also searched to identify ongoing and completed trials. Reference lists of included studies and relevant reviews were also searched. There were no restrictions on the language of publication or publication status.

Author(s): 
Bakarman, Eman O.
Keenan, Analia Veitz
Publication Title: 
Oral Oncology

INTRODUCTION: Salivary gland hypofunction is a common and permanent adverse effect of radiotherapy to the head and neck. Randomised trials of available treatment modalities have produced unclear results and offer little reliable guidance for clinicians to inform evidence-based therapy. We have undertaken this systematic review and meta-analysis to estimate the effectiveness of available interventions for radiotherapy-induced xerostomia and hyposalivation.

Author(s): 
Mercadante, Valeria
Al Hamad, Arwa
Lodi, Giovanni
Porter, Stephen
Fedele, Stefano
Publication Title: 
Current Oncology Reports

In a previous systematic review of the worldwide literature of randomized controlled trials (RCTs) involving needle insertion into acupuncture points for symptom management in cancer patients, we identified only one high-quality RCT that was deemed to have a low risk of bias. Medline, Embase, CINAHL, Cochrane (all databases), Scopus, and PubMed were searched from inception through December 2011 with no language limits applied. A total of 41 RCTs met all inclusion criteria and were rated. In the current review, we examined 18 trials published since our last report.

Author(s): 
Garcia, M. Kay
McQuade, Jennifer
Lee, Richard
Haddad, Robin
Spano, Michael
Cohen, Lorenzo

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