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Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Abused women, who suffer from chronic psychological stress, have been shown to have shorter telomeres than never abused women. Telomere shortening is associated with increased risk of cell death, and it is believed that adopting health-promoting behaviors can help to increase the activity of telomerase, an enzyme that counters telomere shortening. Qigong is an ancient Chinese mind-body integration, health-oriented practice designed to enhance the function of qi, an energy that sustains well-being.

Tiwari, Agnes
Chan, Cecilia Lai Wan
Ho, Rainbow Tin Hung
Tsao, George Sai Wah
Deng, Wen
Hong, Athena Wai Lin
Fong, Daniel Yee Tak
Fung, Helina Yin King Yuk
Pang, Emily Pei Shin
Cheung, Denise Shuk Ting
Ma, Joyce Lai Chong
Publication Title: 
Annals of Behavioral Medicine: A Publication of the Society of Behavioral Medicine

BACKGROUND: Chronic fatigue is common in the general population. Complementary therapies are often used by patients with chronic fatigue or chronic fatigue syndrome to manage their symptoms. PURPOSE: This study aimed to assess the effect of a 4-month qigong intervention program among patients with chronic fatigue or chronic fatigue syndrome. METHODS: Sixty-four participants were randomly assigned to either an intervention group or a wait list control group. Outcome measures included fatigue symptoms, physical functioning, mental functioning, and telomerase activity.

Ho, Rainbow T. H.
Chan, Jessie S. M.
Wang, Chong-Wen
Lau, Benson W. M.
So, Kwok Fai
Yuen, Li Ping
Sham, Jonathan S. T.
Chan, Cecilia L. W.
Publication Title: 
PloS One

Neurogenesis continues throughout the lifetime in the hippocampus, while the rate declines with brain aging. It has been hypothesized that reduced neurogenesis may contribute to age-related cognitive impairment. Ginsenoside Rg1 is an active ingredient of Panax ginseng in traditional Chinese medicine, which exerts anti-oxidative and anti-aging effects. This study explores the neuroprotective effect of ginsenoside Rg1 on the hippocampus of the D-gal (D-galactose) induced aging rat model.

Zhu, Jiahong
Mu, Xinyi
Zeng, Jin
Xu, Chunyan
Liu, Jun
Zhang, Mengsi
Li, Chengpeng
Chen, Jie
Li, Tinyu
Wang, Yaping
Publication Title: 
Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine

OBJECTIVE: To observe the effects of Shoushen Granule, a compound traditional Chinese herbal medicine, on telomere length and telomerase activity in peripheral leukocytes and vascular cells, artery wall lesions and blood lipid in a Sprague-Dawley (SD) rat model of atherosclerosis. METHODS: Forty SD rats were randomly divided into normal control group, model group, Shoushen Granule group and Western medicine group with 10 in each group. The rat model of atherosclerosis was established by high-fat diet and vitamin D3 loading.

Chen, Chuan
Chi, Hui-ying
Yu, Zhi-hua
Chen, Jiu-lin
Publication Title: 
Hua Xi Kou Qiang Yi Xue Za Zhi = Huaxi Kouqiang Yixue Zazhi = West China Journal of Stomatology

OBJECTIVE: To investigate the effect of the traditional Chinese medicine Matrine on cell cycle and human telomerase reverse transcriptase (hTERT) of human ACC-M cell lines. METHODS: Different concentrations of Matrine were used in the medium of ACC-M cells. Change of cell cycle were detected by flow cytometry after ACC-M cell were cultivated with different concentrations Matrine (0.25, 0.50, 0.75, 1.00 mg x mL(-1)). Expression of hTERT was investigated by reverse transcription-polymerase chain reaction (RT-PCR) and indirect immunofluorescene and flow cytometry quantitative analysis.

Zhao, Jun-Fang
Xie, Wei-Hong
Li, Xin-Ming
Chen, Wan-Tao
Sun, Ming-Lei
Fang, Zheng
Sun, Qiang
Publication Title: 
Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA

OBJECTIVE: To observe the effects of classical traditional Chinese medicine prescriptions that function to promote blood circulation and removing blood stasis on the metastatic behavior of malignant tumors, and explore the possible mechanisms of such effects.

Wang, Cheng
Yang, Yun-Gao
Wang, Xue-Liang
Publication Title: 
Longevity & Healthspan

BACKGROUND: Caloric restriction is known to extend the lifespan of all organisms in which it has been tested. Consequently, current research is investigating the role of various foods to improve health and lifespan. The role of various diets has received less attention however, and in some cases may have more capacity to improve health and longevity than specific foods alone. We examined the benefits to longevity of a low glycaemic index (GI) diet in aged Balb/c mice and examined markers of oxidative stress and subsequent effects on telomere dynamics.

Nankervis, Scott A.
Mitchell, Jenee M.
Charchar, Fadi J.
McGlynn, Maree A.
Lewandowski, Paul A.
Publication Title: 
PloS One

Caloric restriction (CR), a reduction of food intake while avoiding malnutrition, can delay the onset of cancer and age-related diseases in several species, including mice. In addition, depending of the genetic background, CR can also increase or decrease mouse longevity. This has highlighted the importance of identifying the molecular pathways that interplay with CR in modulating longevity. Significant lifespan extension in mice has been recently achieved through over-expression of the catalytic subunit of mouse telomerase (mTERT) in a cancer protective background.

Vera, Elsa
Bernardes de Jesus, Bruno
Foronda, Miguel
Flores, Juana M.
Blasco, Maria A.
Publication Title: 
Age (Dordrecht, Netherlands)

After humans, mice are the best-studied mammalian species in terms of their biology and genetics. Gerontological research has used mice and rats extensively to generate short- and long-lived mutants, study caloric restriction and more. Mice and rats are valuable model organisms thanks to their small size, short lifespans and fast reproduction. However, when the goal is to further extend the already long human lifespan, studying fast aging species may not provide all the answers.

Gorbunova, Vera
Bozzella, Michael J.
Seluanov, Andrei
Publication Title: 
FEBS letters

Caloric restriction (CR) is known to effectively elongate mammalian life-spans. The compound 2-deoxy-D-glucose (2DG), which is often used as an inhibitor of glucose utilization, is a mimetic agent of CR. In this study, we examined the changes of telomerase and Werner's syndrome RecQ (WRN) helicase after treatment with 2DG, because of the involvement of recQ helicase in the regulation of telomeres. Interestingly, 2DG treatment increased the expression of WRN protein in accordance with induction of its promoter activity and gene expression.

Zhou, Bei
Ikejima, Takashi
Watanabe, Takeshi
Iwakoshi, Keiko
Idei, Yohei
Tanuma, Sei-ichi
Uchiumi, Fumiaki