Cell Survival

Publication Title: 
Biological & Pharmaceutical Bulletin

Gallic acid (GA) and chebulagic acid (CA) were isolated from the extract of a herbal medicine, kashi (myrobalans: the fruit of Terminalia chebula) as active principles that blocked the cytotoxic T lymphocyte (CTL)-mediated cytotoxicity. GA and CA inhibited the killing activity of CD8+ CTL clone at IC50 values of 30 microM and 50 microM, respectively. Granule exocytosis in response to anti-CD3 stimulation was also blocked by GA and CA at the equivalent concentrations.

Author(s): 
Hamada, S.
Kataoka, T.
Woo, J. T.
Yamada, A.
Yoshida, T.
Nishimura, T.
Otake, N.
Nagai, K.
Publication Title: 
Human & Experimental Toxicology

HP-1 a herbal formulation comprising of Phyllanthus niruri and extracts of Terminalia belerica, Terminalia chebula, Phyllanthus emblica and Tinospora cordifolia has been evaluated for hepatoprotective activity against carbon tetrachloride (CCl4) induced toxicity. Results show that HP-1 reversed the leakage of lactate dehydrogenase (LDH) and glutamate pyruvate transaminase (GPT) and prevented the depletion of glutathione (GSH) levels in a primary monolayer culture of rat hepatocytes (in vitro).

Author(s): 
Tasaduq, S. A.
Singh, K.
Sethi, S.
Sharma, S. C.
Bedi, K. L.
Singh, J.
Jaggi, B. S.
Johri, R. K.
Publication Title: 
Human & Experimental Toxicology

Terminalia chebula Gertn. (Combetraceae) is an important herbal drug in Ayurvedic pharmacopea. In the present study, a 95% ethanolic extract of T. chebula (fruit) (TC extract), which was chemically characterized on the basis of chebuloside II as a marker, was investigated for hepatoprotective activity against anti-tuberculosis (anti-TB) drug-induced toxicity. TC extract was found to prevent the hepatotoxicity caused by the administration of rifampicin (RIF), isoniazid (INH) and pyrazinamide (PZA) (in combination) in a sub-chronic mode (12 weeks).

Author(s): 
Tasduq, S. A.
Singh, K.
Satti, N. K.
Gupta, D. K.
Suri, K. A.
Johri, R. K.
Publication Title: 
Parasitology Research

The absence of a vaccine and the rampant resistance to almost all antimalarial drugs have accentuated the urgent need for new antimalarial drugs and drug targets for both prophylaxis and chemotherapy. The aim of the study was to discover effective plant extracts against Plasmodium falciparum. In the present study, the hexane, chloroform, ethyl acetate, acetone, and methanol extracts of Citrus sinensis (peel), Leucas aspera, Ocimum sanctum, Phyllanthus acidus (leaf), Terminalia chebula (seed) were tested for their antimalarial activity against chloroquine (CQ)-sensitive (3D7) strain of P.

Author(s): 
Bagavan, Asokan
Rahuman, Abdul Abdul
Kamaraj, Chinnaperumal
Kaushik, Naveen Kumar
Mohanakrishnan, Dinesh
Sahal, Dinkar
Publication Title: 
International Braz J Urol: Official Journal of the Brazilian Society of Urology

PURPOSE: Kidney stone is one of the most prevalent diseases worldwide. Calcium oxalate (CaOx) has been shown to be the main component of the majority of stones formed in the urinary system of the patients with urolithiasis. The present study evaluates the antilithiatic properties of Terminalia chebula commonly called as ?harad ? which is often used in ayurveda to treat various urinary diseases including kidney stones. MATERIALS AND METHODS: The antilithiatic activity of Terminalia chebula was investigated on nucleation and growth of the calcium oxalate crystals.

Author(s): 
Tayal, S.
Duggal, S.
Bandyopadhyay, P.
Aggarwal, A.
Tandon, S.
Tandon, C.
Publication Title: 
Molecules (Basel, Switzerland)

Terminalia chebula, native to Southeast Asia, is a popular medicinal plant in Ayurveda. It has been previously reported to have strong antioxidant and anti-inflammatory efficacy. In this study, we aimed to investigate if fruit extract from T. chebula might protect neuronal cells against ischemia and related diseases by reduction of oxidative damage and inflammation in rat pheochromocytoma cells (PC12) using in vitro oxygen-glucose deprivation followed by reoxygenation (OGD-R) ischemia and hydrogen peroxide (H2O2) induced cell death.

Author(s): 
Gaire, Bhakta Prasad
Jamarkattel-Pandit, Nirmala
Lee, Donghun
Song, Jungbin
Kim, Ji Young
Park, Juyeon
Jung, Soyoung
Choi, Ho-Young
Kim, Hocheol
Publication Title: 
Planta Medica

Medicinal plants are a rich source of ligands for nuclear receptors. The present study was aimed to screen a collection of plant extracts for PPAR?/?-activating properties and identify the active extract that can stimulate cellular glucose uptake without enhancing the adipogenesis. A reporter gene assay was performed to screen ethanolic extracts of 263 plant species, belonging to 94 families, for activation of PPAR? and PPAR?. Eight extracts showed activation of PPAR?, while 22 extracts showed activation of PPAR?.

Author(s): 
Yang, Min Hye
Avula, Bharathi
Smillie, Troy
Khan, Ikhlas A.
Khan, Shabana I.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: The herb formulation Deva-5 is used in traditional medicine to treat acute infectious diseases. Deva-5 is composed of five herbs: Gentiana decumbens L., Momordica cochinchinensis L., Hypecoum erectum L., Polygonum bistorta L., and Terminalia chebula Retz. Deva-5 and its five components were investigated for in vitro antiviral activity against avian influenza A virus subtype H3N8. METHODS: The water extracts of the herbal parts of G. decumbens, H. erectum and P. bistorta, the seeds of T. chebula and M.

Author(s): 
Oyuntsetseg, Namsrai
Khasnatinov, Maxim A.
Molor-Erdene, Perenlei
Oyunbileg, Janchiv
Liapunov, Aleksander V.
Danchinova, Galina A.
Oldokh, Sanduijav
Baigalmaa, Jigden
Chimedragchaa, Chimedtseren
Publication Title: 
Scientific Reports

Vascular endothelial growth factor A (VEGFA) plays an important role in tumour angiogenesis and its angiogenic action is mainly mediated through its VEGF receptor 2 (VEGFR-2). Therefore drugs targeting VEGFA/VEGFR-2 are being presently used in the clinics for treatment of several types of solid malignant tumours. We here in report that low dose of chebulagic acid (CA), a hydrolysable tannin found in myrobalan fruits can inhibit VEGFA induced vascular permeability, endothelial cell proliferation, migration, tube formation and thereby, angiogenesis by suppressing VEGFR-2 phosphorylation.

Author(s): 
Lu, Kai
Basu, Sujit
Publication Title: 
Toxicology in vitro: an international journal published in association with BIBRA

Advanced glycation end-products (AGEs) are formed during normal aging, and at an accelerated rate in metabolic syndrome patients. Nonalcoholic steatohepatitis (NASH) can be caused by the AGEs in plasma, while glyceraldehyde-derived AGEs (glycer-AGEs) are significantly higher in the serum of NASH patients. In this study, we investigated the molecular mechanisms of chebulic acid, isolated from Terminalia chebula Retz., in the inhibition of glycer-AGEs induced production of reactive oxygen species (ROS) and collagen accumulation using the LX-2 cell line.

Author(s): 
Koo, Yun-chang
Pyo, Min Cheol
Nam, Mi-Hyun
Hong, Chung-Oui
Yang, Sung-Yong
Lee, Kwang-Won

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