Publication Title: 
Journal of Veterinary Pharmacology and Therapeutics

The aim of this study was to determine the relative potency of racemic ketamine and S(+)-ketamine for the hypnotic effect and to evaluate the clinical anesthesia produced by equianesthetic doses of these two substances in dogs. One hundred and eight dogs were allocated in groups R2, R2.5, R3, R6, R9, R12, S2, S2.5, S3, S6, S9, and S12, to receive by intravenous route 2, 2.5, 3, 6, 9, and 12 mg/kg of ketamine or S(+)-ketamine, respectively. A dose-effect curve was drawn with the dose logarithm and the percentage of dogs that presented hypnosis in each group.

Duque, J. C.
Oleskovicz, N.
Guirro, E. C. B. P.
Valadão, C. a. A.
Soares, V. E.
Publication Title: 
Acta Cirúrgica Brasileira / Sociedade Brasileira Para Desenvolvimento Pesquisa Em Cirurgia

PURPOSE: To evaluate and describe immediate effects of the infusion of saline solution heated by SAF in bitches submitted to halothane anesthesia. METHODS: Thirteen bitches were employed and submitted to elective ovariohysterectomy in acclimatized operating room at 22 degrees C, allocated in two groups: GI, which received non-heated fluid and GII, which received fluid heated at 37 degrees C by SAF.

Atayde, Ingrid Bueno
Franco, Leandro Guimarães
Silva, Marco Augusto Machado
Soares, Lorena Karine
Bittencourt, João Bosco
Fioravanti, Maria Clorinda Soares
Borges, Alinne Cardoso
Silva, Luiz Antônio Franco da
Publication Title: 
Veterinary Anaesthesia and Analgesia

OBJECTIVE: To assess the effect of halothane (H), isoflurane (I) or sevoflurane (S) on the bispectral index (BIS), and the effect of the addition of meperidine in dogs subjected to ovariohysterectomy. STUDY DESIGN: Prospective, randomized, blinded, clinical trial. ANIMALS: Forty-eight female mixed-breed dogs, with weights varying from 10 to 25 kg. METHODS: All dogs were premedicated with acepromazine (A) (0.1 mg kg(-1) IM) or A and meperidine (M) (3 mg kg(-1) IM) and they were divided into six groups of eight animals (AH, AMH, AI, AMI, AS, and AMS).

de Mattos-Junior, Ewaldo
Ito, Kelly C.
Conti-Patara, Andreza
de Carvalho, Haley da Silva
Reinoldes, Adriane
Caldeira, Juliana de Araújo
Cortopassi, Silvia R. G.
Publication Title: 
Antimicrobial Agents and Chemotherapy

The sesquiterpene endoperoxide antimalarial agents arteether and artemether have been reported to cause neurotoxicity with a discrete distribution in the brain stems of rats and dogs after multiple doses. The nature and distribution of the brain lesions suggest a specific neuronal target, the identity of which is unknown.

Wesche, D. L.
DeCoster, M. A.
Tortella, F. C.
Brewer, T. G.
Publication Title: 
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica

To study the histopathological change of the liver of the hosts treated with artemether (Art) or praziquantel (Pra) in early stage after infection with Schistosoma japonicum cercariae. METHODS: Dogs infected once with schistosome cercariae were treated ig with Art 10 or Art capsule (ArtC) 15 on d 7, or praziquantel (Pra) 30-40 on d 21 after infection, followed by the repeated dosing once every 1 or 2 wk for 2-4 times.

Xiao, S. H.
Yang, Y. Q.
Zhang, C. W.
You, J. Q.
Publication Title: 
Cancer Research

Nearly all cervical cancers are etiologically attributable to human papillomavirus (HPV) infection and pharmaceutical treatments targeting HPV-infected cells would be of great medical benefit. Because many neoplastic cells (including cervical cancer cells) overexpress the transferrin receptor to increase their iron uptake, we hypothesized that iron-dependent, antimalarial drugs such as artemisinin might prove useful in treating HPV-infected or transformed cells.

Disbrow, Gary L.
Baege, Astrid C.
Kierpiec, Katie A.
Yuan, Hang
Centeno, Jose A.
Thibodeaux, Clare A.
Hartmann, Dan
Schlegel, Richard
Publication Title: 
The American Journal of Tropical Medicine and Hygiene

Pharmacokinetic and pharmacodynamic responses were evaluated after intramuscular (i.m.) injection of artesunate (AS). Twelve dogs were injected with i.m. AS at 2.5, 5, or 10 mg/kg into the left gluteal muscle. A second injection of only diluent was given in the right gluteal muscle. At 24 hours post-injection, plasma creatine kinase (CK) concentrations were elevated above normal. Muscle biopsies showed myocyte necrosis and acute inflammation, which was worse on the treated side. At 7 days after injection, CK concentrations were normal.

Bennett, Kent
Si, Yuanzheng
Steinbach, Thomas
Zhang, Jing
Li, Qigui
Publication Title: 
PloS One

The objective of our study was to profile and compare the systematic changes between orally administered artesunate and intramuscularly injected artemether at a low dose over a 3-month period (92 consecutive days) in dogs. Intramuscular administration of 6 mg kg-1 artemether induced a decreased red blood cell (RBC) count (anemia), concurrent extramedullary hematopoiesis in the spleen and inhibition of erythropoiesis in the bone marrow.

Yin, Ji-ye
Wang, He-mei
Wang, Quan-jun
Dong, Yan-sheng
Han, Gang
Guan, Yong-biao
Zhao, Ke-yong
Qu, Wen-sheng
Yuan, Ye
Gao, Xiao-xin
Jing, Shu-fang
Ding, Ri-gao
Publication Title: 
Journal of the American Veterinary Medical Association

OBJECTIVE: To evaluate the efficacy of the ambient odor of lavender as a treatment for travel-induced excitement in dogs. DESIGN: Clinical trial. Animals-32 dogs with a history of travel-induced excitement in owners' cars. PROCEDURES: Each dog was studied during travel in the owner's car to a familiar walking site during 2 conditions of olfactory stimulation. The first condition was a control condition, during which dogs were exposed to no odor other than that arising naturally from the environment.

Wells, Deborah L.
Publication Title: 
HPB surgery: a world journal of hepatic, pancreatic and biliary surgery

Acute necrotising pancreatitis is associated with an unacceptably high mortality for which no satisfactory remedy exists. Emblica officinalis (E.o.) is a plant prescribed in Ayurveda, the Indian traditional system of medicine, for pancreas-related disorders. This study was carried out to evaluate the protective effect of E.o. against acute necrotising pancreatitis in dogs. Pancreatitis was induced by injecting a mixture of trypsin, bile and blood into the duodenal opening of the pancreatic duct.

Thorat, S. P.
Rege, N. N.
Naik, A. S.
Thatte, U. M.
Joshi, A.
Panicker, K. N.
Bapat, R. D.
Dahanukar, S. A.


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