Publication Title: 
BMC microbiology

BACKGROUND: Lactobacillus plantarum is considered as a safe and effective probiotic microorganism. Among various sources of isolation, traditionally fermented foods are considered to be rich in Lactobacillus spp., which can be exploited for their probiotic attribute. Antibacterial property of L. plantarum has been demonstrated against various enteric pathogens in both in vitro and in vivo systems. This study was aimed at characterizing L.

Kumar, Himanshu
Rangrez, Ashraf Y.
Dayananda, Kannayakanahalli M.
Atre, Ashwini N.
Patole, Milind S.
Shouche, Yogesh S.
Publication Title: 
Indian Journal of Experimental Biology

Makaradhwaja, an alchemical Ayurvedic mercury preparation is used as stimulant and vitalizer. Towards veterinary practices, the acceptability, tolerability and toxicity studies were undertaken in geriatric pet dogs aged more than 10 years irrespective of breed and sex for future use. Makaradhwaja (2.5 mg/kg) was used with honey once daily for 30 days. Before and after treatment, blood was collected for hematological studies as well as liver, kidney function and anti-oxidant activity.

Sinyorita, S.
Ghosh, C. K.
Chakrabarti, A.
Auddy, B.
Ghosh, Runa
Debnath, P. K.
Publication Title: 
Journal of the American Animal Hospital Association

The use of complementary and alternative medical therapies is becoming widespread. The objective of this study was to examine the use of complementary and alternative therapies in dogs and cats with cancer. The types of modalities used, the intended purpose for each modality, sources of information pet owners used, and the level of interest in these modalities were all evaluated. Information was obtained by written survey, and 254 owners agreed to participate. Complementary and alternative therapy use was commonplace, with 76% of surveyed owners reporting some use.

Lana, Susan E.
Kogan, Lori R.
Crump, Ken A.
Graham, J. Terry
Robinson, Narda G.
Publication Title: 
The Journal of the American Osteopathic Association

The thoracic pump and the abdominal pump are osteopathic manipulative (OM) lymphatic pump techniques frequently used by osteopathic physicians to treat patients with infections (eg, pneumonia, otitis media). Although there is a widely accepted belief among the osteopathic medical profession that increasing lymphatic flow is beneficial, no measurements of lymph flow during osteopathic manipulative treatment have been reported. The authors surgically instrumented five mongrel dogs to record lymphatic flow in the thoracic duct (TDF) and cardiac variables during three intervention protocols.

Knott, E. Marty
Tune, Johnathan D.
Stoll, Scott T.
Downey, H. Fred
Publication Title: 
Cancer Research

Nearly all cervical cancers are etiologically attributable to human papillomavirus (HPV) infection and pharmaceutical treatments targeting HPV-infected cells would be of great medical benefit. Because many neoplastic cells (including cervical cancer cells) overexpress the transferrin receptor to increase their iron uptake, we hypothesized that iron-dependent, antimalarial drugs such as artemisinin might prove useful in treating HPV-infected or transformed cells.

Disbrow, Gary L.
Baege, Astrid C.
Kierpiec, Katie A.
Yuan, Hang
Centeno, Jose A.
Thibodeaux, Clare A.
Hartmann, Dan
Schlegel, Richard
Publication Title: 
Drug Metabolism and Disposition: The Biological Fate of Chemicals

Amoxicillin and cefaclor are two of the widely used beta-lactam antibiotics in the treatment of urinary tract infections. Both drugs are eliminated mainly by the kidney and rely on renal excretion to exert their antibacterial activities in the urinary tract. Previous studies have suggested the involvement of organic anion and oligopeptide transporters in membrane transport of beta-lactams.

Li, Meng
Anderson, Gail D.
Phillips, Brian R.
Kong, Wei
Shen, Danny D.
Wang, Joanne
Publication Title: 
Lymphatic Research and Biology

BACKGROUND: Lymphatic pump techniques (LPT) are used clinically by osteopathic practitioners for the treatment of edema and infection; however, the mechanisms by which LPT enhances lymphatic circulation and provides protection during infection are not understood. Rhythmic compressions on the abdomen during LPT compress the abdominal area, including the gut-associated lymphoid tissues (GALT), which may facilitate the release of leukocytes from these tissues into the lymphatic circulation.

Hodge, Lisa M.
Bearden, Melissa K.
Schander, Artur
Huff, Jamie B.
Williams, Arthur
King, Hollis H.
Downey, H. Fred
Publication Title: 
Molecular Nutrition & Food Research

SCOPE: Theaflavin-2 (TF-2), a major component of black tea extract, induces apoptosis of human colon cancer cells and suppresses serum-induced cyclooxygenase-2 (COX-2) expression 1. Here, we explored the mechanisms for activation of apoptosis, evaluated the impact on inflammatory genes in a broader panel of cells and tested whether topical anti-inflammatory effects could be observed in vivo. METHODS AND RESULTS: TF-2 triggered apoptosis in five other transformed cancer cell lines, inducing cell shrinkage, membrane blebbing, and mitochondrial clustering within 3 h of treatment.

Gosslau, Alexander
En Jao, David Li
Huang, Mou-Tuan
Ho, Chi-Tan
Evans, Dave
Rawson, Nancy E.
Chen, Kuang Yu
Publication Title: 
Lymphatic Research and Biology

BACKGROUND: Osteopathic lymphatic pump treatments (LPT) are used to treat edema, but their direct effects on lymph flow have not been studied. In the current study, we examined the effects of LPT on lymph flow in the thoracic duct of instrumented conscious dogs in the presence of edema produced by constriction of the inferior vena cava (IVC). METHODS AND RESULTS: Six dogs were surgically instrumented with an ultrasonic flow transducer on the thoracic lymph duct and catheters in the descending thoracic aorta and in IVC.

Prajapati, Parna
Shah, Pankhil
King, Hollis H.
Williams, Arthur G.
Desai, Pratikkumar
Downey, H. Fred
Publication Title: 
Journal of Alzheimer's disease: JAD

Alzheimer's disease (AD) involves multiple pathological processes in the brain, including increased inflammation and oxidative damage, as well as the accumulation of amyloid-β (Aβ) plaques. We hypothesized that a combinatorial therapeutic approach to target these multiple pathways may provide cognitive and neuropathological benefits for AD patients. To test this hypothesis, we used a canine model of human aging and AD. Aged dogs naturally develop learning and memory impairments, human-type Aβ deposits, and oxidative damage in the brain.

Head, Elizabeth
Murphey, Heather L.
Dowling, Amy L. S.
McCarty, Katie L.
Bethel, Samuel R.
Nitz, Jonathan A.
Pleiss, Melanie
Vanrooyen, Jenna
Grossheim, Mike
Smiley, Jeffery R.
Murphy, M. Paul
Beckett, Tina L.
Pagani, Dieter
Bresch, Frederick
Hendrix, Curt


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