Forecasting

Publication Title: 
MÈdecine Sciences: M/S

Aging is a complex process that is accompanied by the onset of a series of age-related diseases, including Alzheimer's disease. Aging is controlled by a combination of genetic and environmental factors. Among the genes that regulate aging, the insulin-FOXO signaling pathway plays a central role, as this pathway regulates lifespan in multiple species, such as worms, flies, and mice. In humans, exceptional longevity - being a centenarian - is also associated with genetic variation in this insulin-FOXO pathway.

Author(s): 
Brunet, Anne
Publication Title: 
Journal of the Neurological Sciences

The burden of cognitive disorders is likely to increase over the coming years due to both increased longevity and altered risk factor patterns, arising from changes in lifestyle, healthcare and society. Vascular dementia with its underlying heterogeneous pathology, is a challenge for clinicians, and is frequently further aggravated by overlap with other neurodegenerative processes. Current Alzheimer's disease drugs have had limited clinical efficacy in treating vascular dementia and none have been approved by major regulatory authorities specifically for this disease.

Author(s): 
Skoog, Ingmar
Korczyn, Amos D.
Guekht, Alla
Publication Title: 
MÈdecine Sciences: M/S

Aging is a complex process that is accompanied by the onset of a series of age-related diseases, including Alzheimer's disease. Aging is controlled by a combination of genetic and environmental factors. Among the genes that regulate aging, the insulin-FOXO signaling pathway plays a central role, as this pathway regulates lifespan in multiple species, such as worms, flies, and mice. In humans, exceptional longevity - being a centenarian - is also associated with genetic variation in this insulin-FOXO pathway.

Author(s): 
Brunet, Anne
Publication Title: 
Journal of the American Geriatrics Society

Where should we look to find the causes of and cure for aging? This essay considers a number of scientific discoveries, not yet made, that might dramatically increase the proportion of biogerontologists doing useful work. I will consider, in turn, problems and prospects in the areas of comparative biology, mammalian and invertebrate genetics, biomarker research, caloric restriction, and clonal senescence and then conclude with a discussion of potential links between aging and late life disease.

Author(s): 
Miller, R. A.
Publication Title: 
Sexually Transmitted Infections

OBJECTIVES: To investigate the psychosocial impact of lipodystrophy on the lifestyles of HIV positive patients on highly active antiretroviral therapy (HAART). METHODS: In-depth interviews were conducted with 14 HIV positive patients on HAART at an outpatient sexually transmitted infections (STI) and HIV clinic in central London. Qualitative data from interview transcripts were analysed using grounded theory to elicit key categories and subcategories.

Author(s): 
Power, R.
Tate, H. L.
McGill, S. M.
Taylor, C.
Publication Title: 
The New England Journal of Medicine
Author(s): 
Carpenter, Arielle H.
Publication Title: 
Science (New York, N.Y.)
Author(s): 
Couzin, Jennifer
Publication Title: 
Journal of the American Geriatrics Society

Dietary caloric restriction is the most reproducible means of extending longevity and maintaining health and vitality. It has been shown to be relevant to a wide rage of species, including primates. Examination of key markers of the calorically restricted phenotype, such as plasma insulin, dehydroepiandrosterone sulfate, and body temperature, suggest that they may predict longevity in humans as well. However, most people would be unwilling or unable to adopt the 30% to 40% reduction in food intake necessary to achieve optimal health and longevity benefits.

Author(s): 
Roth, George S.
Publication Title: 
Age (Dordrecht, Netherlands)

Dietary pattern analysis represents a useful improvement in the investigation of diet and health relationships. Particularly, the Mediterranean diet pattern has been associated with reduced mortality risk in several studies involving both younger and elderly population groups. In this research, relationships between dietary macronutrient composition, as well as the Mediterranean diet, and total mortality were assessed in 1,037 seventy-year-old subjects (540 females) information.

Author(s): 
Tognon, Gianluca
Rothenberg, Elisabet
Eiben, Gabriele
Sundh, Valter
Winkvist, Anna
Lissner, Lauren
Publication Title: 
MÈdecine Sciences: M/S

In half a century, the number of nonagenarians and/or centenarians has dramatically increased, particularly due to the increase in life expectancy at old age. However, successful aging is more important than longevity. All along their life, people can act to preserve their health, their physical and mental abilities as well as their autonomy. This requires a healthy diet, having physical and intellectual appropriate activities and a right use of medical care. Finally, maintaining a social role and a raison d'Ítre in old age are also major factors in successful aging.

Author(s): 
Berr, Claudine
Balard, FrÈdÈric
Blain, Hubert
Robine, Jean-Marie

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