Heart Rate

Publication Title: 
The American Journal of Clinical Hypnosis

Forearm arterial flow was measured in 22 healthy first-time blood donors during a 300-ml. blood letting and during the subsequent recovery. Blood pressure (BP) was also taken simultaneously and forearm peripheral resistance calculated. Following a transient BP and flow increase due to tachycardia related to needle insertion, both systolic BP and flow progressively and significantly decreased, while resistance increased. In a further 22 sex- and aged-matched highly hypnotizable subjects, blood donation was simulated by means of verbal hypnotic suggestions.

Author(s): 
Casiglia, E.
Mazza, A.
Ginocchio, G.
Onesto, C.
Pessina, A. C.
Rossi, A.
Cavatton, G.
Marotti, A.
Publication Title: 
The Journal of Pharmacology and Experimental Therapeutics

This study characterizes the pharmacokinetic-pharmacodynamic (PK-PD) relationships of the cardiovascular, EEG, hypnotic and ventilatory effects of the alpha-2 adrenergic agonist dexmedetomidine in rats. Dexmedetomidine was administered by a single rapid infusion (n = 6) and by an infusion regimen of gradually increasing rate (n = 8). HR, mean arterial pressure (MAP) and EEG signals were recorded continuously, as was the time at which the rats woke up spontaneously from drug-induced sleep, a measure of hypnosis.

Author(s): 
Bol CJJG, null
Danhof, M.
Stanski, D. R.
Mandema, J. W.
Publication Title: 
International Journal of Psychophysiology: Official Journal of the International Organization of Psychophysiology

The purpose of the present research was to find physiological and cognitive correlates of hypnosis, imaginative suggestibility and emotional experiences. After the administration of a standard hypnotic induction, the EEG and heart rate (HR) were recorded during self-generated happy and sad emotions using a relaxation condition as a control. Physiological recordings were also obtained during three eyes-open and eyes-closed baseline periods: (1) waking rest; (2) early-rest in hypnosis (just after the hypnotic induction); (3) late-rest hypnosis (at the end of hypnotic condition).

Author(s): 
De Pascalis, V.
Ray, W. J.
Tranquillo, I.
D'Amico, D.
Publication Title: 
Acta Anaesthesiologica Belgica

We studied nociception-associated arousal following laryngoscopy and intubation in patients scheduled for elective open heart surgery, using EEG power spectra and hemodynamics. Either fentanyl (7 micrograms/kg; n = 30) or sufentanil (1 microgram/kg; n = 30) were given in a randomized fashion to induce anesthesia in heavily premedicated patients, followed by pancuronium bromide (100 micrograms/kg).

Author(s): 
Freye, E.
Dehnen-Seipel, H.
Latasch, L.
Behler, M.
Wilder-Smith, O. H.
Publication Title: 
The Journal of Pharmacology and Experimental Therapeutics

The influence of hypovolemia (removal of 30% of the blood volume) on the pharmacokinetics and pharmacodynamics of etomidate was investigated in the rat. Chronically instrumented animals were randomly allocated to either a control (n = 9) or a hypovolemia (n = 9) group, and etomidate was infused (50 mg/kg/h) until isoelectric periods of 5 s or longer were observed in the electroencephalogram. The changes observed in the electroencephalogram were quantified using aperiodic analysis in the 2.5- to 7.5-Hz frequency band and used as a surrogate measure of hypnosis.

Author(s): 
De Paepe, P.
Belpaire, F. M.
Van Hoey, G.
Boon, P. A.
Buylaert, W. A.
Publication Title: 
Psychological Reports

10 female physical education students were given posthypnotic suggestions alluding to economy of effort in exercise. These suggestions were affirmed under self-hypnosis over two weeks. Experimental subjects pedalled on an exercise bicycle for 20 min. at 60% of their maximal work capacity while listening to suggestions from a hypnotist. The Control group (n = 9) showed no differences between mean pretest and posttest scores on physical self-efficacy, trait anxiety, state anxiety, heart rate, blood pressure, and perceived rate of exertion.

Author(s): 
DeVos, H. M.
Potgieter, J. R.
Blaauw, J. H.
Publication Title: 
The Journal of Pharmacology and Experimental Therapeutics

This study characterizes the anesthetic profile of dexmedetomidine on the basis of steady-state plasma concentrations using defined stimulus-response, ventilatory, and continuous electroencephalographic (EEG) and cardiovascular effect measures in rats.

Author(s): 
Bol, C. J.
Vogelaar, J. P.
Mandema, J. W.
Publication Title: 
The International Journal of Clinical and Experimental Hypnosis

This paper was designed to examine the relationship between hypnotic susceptibility and cardiovascular measures, especially parasympathetic activity, in 3 separate studies. In these studies, neither heart rate nor heart rate variability differed between the high and low hypnotically susceptible individuals at the initial baseline. Furthermore, in the first study, experimental tasks designed to elicit differential sympathetic and parasympathetic cardiac responses demonstrated no interaction with hypnotic susceptibility.

Author(s): 
Ray, W. J.
Sabsevitz, D.
De Pascalis, V.
Quigley, K.
Aikins, D.
Tubbs, M.
Publication Title: 
Anaesthesiologie Und Reanimation

Oculocardial reflex (OCR) occurs particularly through manipulation of the medial rectus muscle and results in a bradycardic arrhythmia. In children the incidence is between 60 and 80%. After using sevoflurane in clinical practice, the absence or non-occurrence of this reflex was observed. The data of 180 healthy children aged between four and 14 years who had to undergo strabismus surgery under general anaesthesia were analysed: group I (n = 92), group II (n = 88). All children received standard premedication with midazolam, no anticholinergic drugs were administered.

Author(s): 
Goerlich, T. M.
Foja, C.
Olthoff, D.
Publication Title: 
European Journal of Anaesthesiology

We investigated the effect of a small dose of midazolam, ketamine, droperidol or lidocaine on the propofol dose required for hypnosis during induction of general anaesthesia. These drugs were randomly administered to 100 patients about to undergo scheduled surgery. Propofol was then infused at a rate of 250 microg kg-1 min-1 and the hypnotic dose to produce hypnosis was evaluated.

Author(s): 
Adachi, Y. U.
Uchihashi, Y.
Watanabe, K.
Satoh, T.

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