Japan

Publication Title: 
Journal of Clinical Epidemiology

We applied the Weibull distribution to the life-table and age-patterns of diseases in Japan. The life-table follows a composite Weibull distribution composed of initial failure and two stage wear-out failure periods. The extension of lifespan during the past century is manifested as increases in the scale parameters in all three periods and the shape parameters in the wear-out periods with female predominancy. The shape parameters of diseases show time-independent sex-dependent specific values.

Author(s): 
Matsushita, S.
Hagiwara, K.
Shiota, T.
Shimada, H.
Kuramoto, K.
Toyokura, Y.
Publication Title: 
Biogerontology

Caloric (or dietary) restriction (CR) extends lifespan and lowers risk for age associated diseases in a phylogenetically diverse group of species. Whether prolonged CR increases average or maximum lifespan or promotes a more youthful physiology in humans at advanced ages is not yet known. However, available epidemiological evidence indicates that CR may already have contributed to an extension of average and maximum life span in one human population and appears to have lowered risk for age associated chronic diseases in other human populations.

Author(s): 
Willcox, D. Craig
Willcox, Bradley J.
Todoriki, Hidemi
Curb, J. David
Suzuki, Makoto
Publication Title: 
Journal of Nutritional Science and Vitaminology

Calcium deficiency is a constant menace to land-abiding animals, including mammals. Humans enjoying exceptional longevity on earth are especially susceptible to calcium deficiency in old age.

Author(s): 
Fujita, T.
Publication Title: 
Asia Pacific Journal of Clinical Nutrition

Okinawans, who have a different ethnicity and food cultural history to other Japanese nationals, and an exceptional longevity have been studied at home and as migrant groups in Hawaii and Brazil. Biomarkers for fish and soy intake and intervention studies indicate that these foods, along with seaweed and green vegetables are candidates for chronic non-communicable disease prevention.

Author(s): 
Yamori, Y.
Miura, A.
Taira, K.
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

BACKGROUND: Centenarians are sometimes said to be representative of lifelong healthy aging. Whether they are, in fact, examples of healthy aging remains a subject of debate. The existence of heterogeneity in functional status has been reported repeatedly in previous studies of centenarians. However, there is as yet no standardized classification system with which to describe their functional phenotype. METHODS: As part of a dynamic cohort study, we studied 304 centenarians (65 men and 239 women) living in Tokyo.

Author(s): 
Gondo, Yasuyuki
Hirose, Nobuyoshi
Arai, Yasumichi
Inagaki, Hiroki
Masui, Yukie
Yamamura, Ken
Shimizu, Ken-ichirou
Takayama, Michiyo
Ebihara, Yoshinori
Nakazawa, Susumu
Kitagawa, Koji
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

Okinawa, an isolated island prefecture of Japan, has among the highest prevalence of exceptionally long-lived individuals in the world; therefore, we hypothesized that, within this population, genes that confer a familial survival advantage might have clustered. We analyzed the pedigrees of 348 centenarian families with 1142 siblings and compared sibling survival with that of the 1890 Okinawan general population cohort. Both male and female centenarian siblings experienced approximately half the mortality of their birth cohort-matched counterparts.

Author(s): 
Willcox, Bradley J.
Willcox, D. Craig
He, Qimei
Curb, J. David
Suzuki, Makoto
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

BACKGROUND: High-density lipoprotein cholesterol (HDL-C) and cholesteryl ester transfer protein (CETP) gene deficiency mutations that increase HDL-C levels have been associated with exceptional longevity. However, a recent clinical trial of a promising CETP inhibitor that markedly increases HDL-C was terminated due to increased mortality. In light of this controversy, we examined the relationship among HDL-C, CETP mutations, and longevity phenotypes in the long-lived Japanese-American men of the Honolulu Heart Program (HHP).

Author(s): 
Koropatnick, Tanya A.
Kimbell, Jennifer
Chen, Randi
Grove, John S.
Donlon, Timothy A.
Masaki, Kamal H.
Rodriguez, Beatriz L.
Willcox, Bradley J.
Yano, Katsuhiko
Curb, J. David
Publication Title: 
Journal of Nutritional Science and Vitaminology

Calcium deficiency is a constant menace to land-abiding animals, including mammals. Humans enjoying exceptional longevity on earth are especially susceptible to calcium deficiency in old age.

Author(s): 
Fujita, T.
Publication Title: 
BMJ (Clinical research ed.)
Author(s): 
Walsh, G. P.
Publication Title: 
Nutrition and Health

Several factors, such as environment and heredity, are presumed to be related to longevity. Of these nutrition is believed to function as a regulatory factor. Okinawa prefecture is well known as the leading area for longevity in the world. We therefore examined present and past nutrition records together with the background of all the 88 centenarians (18 male, 70 female) who are living in Okinawa in 1991. Their leading occupation was agriculture, and they were in work until the 8th decade.

Author(s): 
Mimura, G.
Murakami, K.
Gushiken, M.

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