Radiation Injuries

Publication Title: 
International Journal of Radiation Oncology, Biology, Physics

PURPOSE: To investigate the incidence of and variables associated with clinically evident fat necrosis in women treated on a protocol of high-dose-rate (HDR) brachytherapy alone without external-beam whole-breast irradiation for early-stage breast carcinoma. METHODS AND MATERIALS: From 6/1997 until 8/1999, 30 women diagnosed with Stage I or II breast carcinoma underwent surgical excision and postoperative irradiation via HDR brachytherapy implant as part of a multi-institutional clinical Phase I/II protocol.

Author(s): 
Wazer, D. E.
Lowther, D.
Boyle, T.
Ulin, K.
Neuschatz, A.
Ruthazer, R.
DiPetrillo, T. A.
Publication Title: 
The American Journal of Clinical Hypnosis

This case report describes an effort to control two primary side-effects of breast cancer radiotherapy (fatigue and skin discomfort) that used a combination of cognitive-behavioral therapy with hypnosis (CBTH). Two patients, matched on demographic and medical variables (marital status, employment status, number of children, cancer diagnosis, surgical history, radiation dose), were compared: one who received a CBTH intervention and one who received standard care.

Author(s): 
Schnur, Julie B.
Montgomery, Guy H.
Publication Title: 
Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association

OBJECTIVE: The study purpose was to test the effectiveness of a psychological intervention combining cognitive-behavioral therapy and hypnosis (CBTH) to treat radiotherapy-related fatigue. DESIGN: Women (n = 42) scheduled for breast cancer radiotherapy were randomly assigned to receive standard medical care (SMC) (n = 20) or a CBTH intervention (n = 22) in addition to SMC. Participants assigned to receive CBTH met individually with a clinical psychologist. CBTH participants received training in hypnosis and CBT.

Author(s): 
Montgomery, Guy H.
Kangas, Maria
David, Daniel
Hallquist, Michael N.
Green, Sheryl
Bovbjerg, Dana H.
Schnur, Julie B.
Publication Title: 
Die Nahrung

The effect of 5, 10, 20, 40, 60, 80, 100, 120, and 160 mg/kg body weight (b.wt.) of aqueous extract of cystone (an ayurvedic herbal medicine) administered intraperitoneally was studied on the radiation-induced mortality in mice exposed to 10 Gy of gamma-radiation. Treatment of mice with different doses of cystone, consecutively for five days before irradiation, delayed the onset of mortality and reduced the symptoms of radiation sickness when compared with the non-drug treated irradiated controls.

Author(s): 
Jagetia, Ganesh Chandra
Baliga, Manjeshwar Shrinath
Publication Title: 
Phytomedicine: International Journal of Phytotherapy and Phytopharmacology

Turmeric (the rhizomes of Curcuma longa L., Zingiberacease) is widely used as a dietary pigment and spice, and has been traditionally used for the treatment of inflammation, skin wounds and hepatic disorders in Ayurvedic, Unani and Chinese medicine. Although the topical application or oral administration of turmeric is used to improve skin trouble, there is no evidence to support this effect. The aim of this study was to clarify whether turmeric prevents chronic ultraviolet B (UVB)-irradiated skin damage.

Author(s): 
Sumiyoshi, Maho
Kimura, Yoshiyuki
Publication Title: 
Integrative Cancer Therapies

Numerous botanical agents, many of which are used in whole medical system practices (i.e. traditional Chinese medicine, Ayurvedic medicine, etc.), have been shown to exhibit radiomodifying effects on tumors and normal tissues in-vitro and in-vivo studies. Some of these agents can enhance the therapeutic gain of radiation therapy by either acting as a radiosensitizer to tumor cells and/or as a radioprotector to normal cells.

Author(s): 
Lawenda, Brian D.
Publication Title: 
Integrative Cancer Therapies

Effects of an integrated yoga program in modulating perceived stress levels, anxiety, as well as depression levels and radiation-induced DNA damage were studied in 68 breast cancer patients undergoing radiotherapy. Two psychological questionnaires--Hospital Anxiety and Depression Scale (HADS) and Perceived Stress Scale (PSS)--and DNA damage assay were used in the study. There was a significant decrease in the HADS scores in the yoga intervention group, whereas the control group displayed an increase in these scores.

Author(s): 
Banerjee, Birendranath
Vadiraj, H. S.
Ram, Amritanshu
Rao, Raghavendra
Jayapal, Manikandan
Gopinath, Kodaganur S.
Ramesh, B. S.
Rao, Nalini
Kumar, Ajay
Raghuram, Nagarathna
Hegde, Sridevi
Nagendra, H. R.
Prakash Hande, M.
Publication Title: 
Cancer Nursing

A descriptive study was conducted on self-reported symptoms and self-care by 37 adults receiving chemotherapy primarily for leukemia, lymphomas, or breast cancer or radiation therapy for head and neck or lung cancers. The Therapy-Related Symptom Checklist and demographic and interview forms on self-care for identified symptoms were used. Severe symptoms on the Therapy-Related Symptom Checklist subscales fatigue, eating, nausea, pain, numbness in fingers/toes, hair loss, and constipation were reported by patients on chemotherapy.

Author(s): 
Williams, Phoebe Dauz
Piamjariyakul, Ubolrat
Ducey, Kathleen
Badura, Jody
Boltz, Kristin D.
Olberding, Karmen
Wingate, Anita
Williams, Arthur R.
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

BACKGROUND: Ionizing radiation (IR) initiates intracellular oxidative stress through enhanced formation of reactive oxygen species (ROS) that attack DNA leading to cell death. Because of the diversity of IR applied in medicine, agriculture, industry, and the growing threats of global terrorism, the acquisition of radioprotectors is an urgent need for the nation. However, the applicability of radioprotectors currently under investigation is limited due to their inherent toxicity.

Author(s): 
Lee, Tung-Kwang
O'Brien, Kevin F.
Wang, Weidong
Johnke, Roberta M.
Sheng, Chao
Benhabib, Sidi M.
Wang, Tao
Allison, Ron R.
Publication Title: 
Human & Experimental Toxicology

This paper compares the historical developments of chemical and radiation hormesis from their respective inceptions in the late 1880's for chemical hormesis and early 1900's for radiation hormesis to the mid 1930's to 1940 during which both hypotheses rose to some prominence but then became marginalized within the scientific community. This analysis documents that there were marked differences in their respective temporal developments, and the direction and maturity of research.

Author(s): 
Calabrese, E. J.
Baldwin, L. A.

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