Reference Values

Publication Title: 
Physiology & Behavior

The focus of this review is on current research involving long-term calorie restriction (CR) and the resulting changes observed in physiological and behavioral outcomes in humans. Special emphasis will be given to the first completed clinical studies which are currently investigating the effects of controlled, high-quality energy-restricted diets on both biomarkers of longevity and on the development of chronic diseases related to age in humans.

Author(s): 
Redman, Leanne M.
Martin, Corby K.
Williamson, Donald A.
Ravussin, Eric
Publication Title: 
Human Movement Science

This study aimed to continue our characterization of finger strength and multi-finger interactions across the lifespan to include those in their 60s and older. Building on our previous study of children, we examined young and elderly adults during isometric finger flexion and extension tasks. Sixteen young and 16 elderly, gender-matched participants produced maximum force using either a single finger or all four fingers in flexion and extension.

Author(s): 
Oliveira, Marcio A.
Hsu, Jeffrey
Park, Jaebum
Clark, Jane E.
Shim, Jae Kun
Publication Title: 
Age (Dordrecht, Netherlands)

The B cell arm of adaptive immunity undergoes significant modifications with age. Elderly people are characterized by impaired B cell responses reflected in a reduced ability to effectively respond against viruses and bacteria. Alterations of immunity with advancing age (immunosenescence) have been widely studied in centenarians who are considered a good example of successful aging. In recent years, attention has shifted to centenarian offspring (CO) as a model of people genetically advantaged for healthy aging and longevity.

Author(s): 
Buffa, Silvio
PellicanÚ, Mariavaleria
Bulati, Matteo
Martorana, Adriana
Goldeck, David
Caruso, Calogero
Pawelec, Graham
Colonna-Romano, Giuseppina
Publication Title: 
Fiziologiia Cheloveka
Author(s): 
Potemkina, N. S.
Krut'ko, V. N.
Publication Title: 
European Review for Medical and Pharmacological Sciences

Epidemiological and clinical studies have clearly shown a close relationship between plasma cholesterol concentrations and vascular risk. We focused our attention on the phenotypic-biohumoral conditions capable of influencing longevity in relation to different age classes. We evaluated the lipid profile in an elderly institutionalized population of 80 subjects (20 males and 60 females divided into age classes) in the town of Catania.

Author(s): 
Malaguarnera, M.
Giugno, I.
Ruello, P.
Rizzo, M.
Panebianco, M. P.
Pistone, G.
Tomasello, F. B.
Publication Title: 
Human Biology

The purpose of this study was to review published studies on the variability of age at menarche and age at menopause throughout the world, and to identify the main causes for age variation in the timing of these events. We first present a summary table including mean (or median) values of the age at menarche in 67 countries, and of the age at menopause in 26 countries.

Author(s): 
Thomas, F.
Renaud, F.
Benefice, E.
de Mee¸s, T.
Guegan, J. F.
Publication Title: 
Physiology & Behavior

The focus of this review is on current research involving long-term calorie restriction (CR) and the resulting changes observed in physiological and behavioral outcomes in humans. Special emphasis will be given to the first completed clinical studies which are currently investigating the effects of controlled, high-quality energy-restricted diets on both biomarkers of longevity and on the development of chronic diseases related to age in humans.

Author(s): 
Redman, Leanne M.
Martin, Corby K.
Williamson, Donald A.
Ravussin, Eric
Publication Title: 
Nitric Oxide: Biology and Chemistry / Official Journal of the Nitric Oxide Society

BACKGROUND: Japanese longevity is the highest in the world. This is partly explained by low occurrence of cardiovascular diseases, which in turn is attributed to the Japanese traditional diet (JTD). Recent research demonstrates that nitric oxide (NO), a key regulator of vascular integrity, can be generated from nitrate (NO(3)(-)), abundantly found in vegetables. It can reduce blood pressure (BP) via its serial reduction to nitrite (NO(2)(-)) and to bioactive NO. Interestingly, JTD is extremely rich in nitrate and the daily consumption is higher than in any other known diet.

Author(s): 
Sobko, Tanja
Marcus, Claude
Govoni, Mirco
Kamiya, Shigeru
Publication Title: 
Ageing Research Reviews

The mouse has become the favorite mammalian model. Among the many reasons for this privileged position of mice is their genetic proximity to humans, the possibilities of genetically manipulating their genomes and the availability of many tools, mutants and inbred strains. Also in the field of aging, mice have become very robust and reliable research tools.

Author(s): 
Vanhooren, Valerie
Libert, Claude
Publication Title: 
Psychoneuroendocrinology

We previously reported that psychological stress is linked to and possibly accelerates cellular aging, as reflected by lower PBMC telomerase and shortened telomeres. Psychological stress is a major risk factor for cardiovascular disease (CVD), with multiple behavioral and physiological mediators. Telomere shortness has been associated with CVD, but the relationship between low telomerase activity, a potential precursor to telomere shortening, and CVD risk factors has not been examined in humans.

Author(s): 
Epel, Elissa S.
Lin, Jue
Wilhelm, Frank H.
Wolkowitz, Owen M.
Cawthon, Richard
Adler, Nancy E.
Dolbier, Christyn
Mendes, Wendy B.
Blackburn, Elizabeth H.

Pages

Subscribe to RSS - Reference Values