Research Design

Publication Title: 
The Journal of Nutrition, Health & Aging

Caloric restriction (CR), undernutrition without malnutrition, remains the only experimental paradigm that has been shown consistently to extend lifespan and slow aging in short-lived species. Decades of research, mostly in laboratory rodents, have shown that CR consistently extends lifespan, reduces or delays the onset of many age-related diseases and slows aging in many physiological systems. In recent years gerontologists interested in CR have focused on two unanswered questions. 1) What is the relevance of this nutritional paradigm to human aging?

Author(s): 
Lane, M. A.
Ingram, D. K.
Roth, G. S.
Publication Title: 
Journal of Clinical Psychopharmacology

Antidepressant continuation studies have used 2 different designs. In the placebo substitution design, all patients are initially treated with active medication in an open-label fashion, and then treatment responders are randomized to continue with medication or switch to placebo in a double-blind manner. In the extension design, patients are randomized to a double-blind placebo-controlled acute study at the outset, and responders to active treatment and placebo are continued on the treatment to which they initially responded.

Author(s): 
Zimmerman, Mark
Posternak, Michael A.
Ruggero, Camilo J.
Publication Title: 
Mechanisms of Ageing and Development

Identifying the factors that contribute to long and healthy life can lead to improved interventions that can help delay or prevent the onset of major aging-related diseases and disabilities and increase the time that older persons spend in good health. Studies on longevity and other exceptional survival outcomes can contribute to this knowledge.

Author(s): 
Hadley, Evan C.
Rossi, Winifred K.
Publication Title: 
American Journal of Public Health

OBJECTIVES: We investigated the characteristics of the oldest old in China and examined whether the factors associated with longevity varied with advanced age. METHODS: Drawing from the largest nationally representative longitudinal sample of oldest-old adults, we stratified descriptive statistics separately by gender and urban-rural residence and then used ordered logit models to examine the multivariate factors associated with increasing age-group membership.

Author(s): 
Dupre, Matthew E.
Liu, Guangya
Gu, Danan
Publication Title: 
Aging

Individuals from families recruited for the Long Life Family Study (LLFS) (n= 4559) were examined and compared to individuals from other cohorts to determine whether the recruitment targeting longevity resulted in a cohort of individuals with better health and function. Other cohorts with similar data included the Cardiovascular Health Study, the Framingham Heart Study, and the New England Centenarian Study. Diabetes, chronic pulmonary disease and peripheral artery disease tended to be less common in LLFS probands and offspring compared to similar aged persons in the other cohorts.

Author(s): 
Newman, Anne B.
Glynn, Nancy W.
Taylor, Christopher A.
Sebastiani, Paola
Perls, Thomas T.
Mayeux, Richard
Christensen, Kaare
Zmuda, Joseph M.
Barral, Sandra
Lee, Joseph H.
Simonsick, Eleanor M.
Walston, Jeremy D.
Yashin, Anatoli I.
Hadley, Evan
Publication Title: 
The Journal of Nutrition, Health & Aging

Caloric restriction (CR), undernutrition without malnutrition, remains the only experimental paradigm that has been shown consistently to extend lifespan and slow aging in short-lived species. Decades of research, mostly in laboratory rodents, have shown that CR consistently extends lifespan, reduces or delays the onset of many age-related diseases and slows aging in many physiological systems. In recent years gerontologists interested in CR have focused on two unanswered questions. 1) What is the relevance of this nutritional paradigm to human aging?

Author(s): 
Lane, M. A.
Ingram, D. K.
Roth, G. S.
Publication Title: 
Alzheimer Disease and Associated Disorders
Author(s): 
Finch, Caleb E.
Publication Title: 
Annals of the New York Academy of Sciences

Aging involves a gradual increase in disorder of the systems that sustain living. Although stress is a major driver of this process, one stressor, caloric restriction (CR), is the only intervention proven to extend life span in multiple species as well as extend the persistence of those characteristics that are associated with youth. CR has been used since ancient times to enhance many of those characteristics: principally, increased activity levels and heightened levels of mental acuity.

Author(s): 
Mehta, Linda Hotchkiss
Roth, George S.
Publication Title: 
Annals of the New York Academy of Sciences

This paper is intended to serve as a traditional Tibetan medical response to advancements in basic longevity research, with particular attention to current models of caloric restriction. This is a complicated task, as Tibetan medicine traditionally approaches dietary modification from a radically different perspective, and relies upon a complex model of health and balance in the treatment and prevention of disease. This paper offers a brief overview of the traditional Tibetan medicine (TTM) model and suggests potential areas for collaborative research on dietary modification.

Author(s): 
Dakpa, Tenzing
Dodson-Lavelle, Brooke
Publication Title: 
Journal of thrombosis and haemostasis: JTH

The consumption of long chain omega-3 polyunsaturated acids (PUFA) is considered to protect against cardiovascular disease and promote longevity following a heart attack. Historically, research in this area was fuelled by compelling reports of the cardiovascular benefits of omega-3 PUFA in select populations and cultures. More recent studies, in wider populations, suggest discordant findings: differences that are difficult to reconcile as the mechanism of action of omega-3 PUFA are poorly understood.

Author(s): 
Patel, J. V.
Tracey, I.
Hughes, E. A.
Lip, G. Y.

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