Sample Size

Publication Title: 
Research in social & administrative pharmacy: RSAP

BACKGROUND: Pharmacy employers are being challenged to recruit and retain qualified employees. OBJECTIVES: Our study hypothesized that pharmacists who practice pharmaceutical care have an attractive construed external image (how employees think outsiders view their organization), which strengthens their organizational identification (perceptions of oneness with or belongingness to the organization) and decreases job turnover intention (thoughts of quitting/searching for another job).

Author(s): 
O'Neill, Jessica L.
Gaither, Caroline A.
Publication Title: 
The Journal of Pain: Official Journal of the American Pain Society

Yoga has been found effective in the treatment of chronic low back pain. We aimed to evaluate the effectiveness of Iyengar yoga in chronic neck pain by means of a randomized clinical trial. Seventy-seven patients (aged 47.9 ± 7.9, 67 female) with chronic neck pain who scored >40 mm on a 100-mm visual analog scale (VAS) were randomized to a 9-week Iyengar yoga program with weekly 90-minute classes (n = 38) or to a self-care/exercise program (n = 38). Patients were examined at baseline and after 4 and 10 weeks.

Author(s): 
Michalsen, Andreas
Traitteur, Hermann
Lüdtke, Rainer
Brunnhuber, Stefan
Meier, Larissa
Jeitler, Michael
Büssing, Arndt
Kessler, Christian
Publication Title: 
The Journal of Pain: Official Journal of the American Pain Society

Yoga has been found effective in the treatment of chronic low back pain. We aimed to evaluate the effectiveness of Iyengar yoga in chronic neck pain by means of a randomized clinical trial. Seventy-seven patients (aged 47.9 ± 7.9, 67 female) with chronic neck pain who scored >40 mm on a 100-mm visual analog scale (VAS) were randomized to a 9-week Iyengar yoga program with weekly 90-minute classes (n = 38) or to a self-care/exercise program (n = 38). Patients were examined at baseline and after 4 and 10 weeks.

Author(s): 
Michalsen, Andreas
Traitteur, Hermann
Lüdtke, Rainer
Brunnhuber, Stefan
Meier, Larissa
Jeitler, Michael
Büssing, Arndt
Kessler, Christian
Publication Title: 
Southern Medical Journal

BACKGROUND: Physicians and researchers have recently paid increased attention to prayer in physician-patient interactions. Research focuses more on attitudinal questions about whether physicians and/or patients think prayer is relevant than on actual data about when and how prayer comes up in the clinic and how physicians respond. We focus on pediatric physicians to investigate: 1) how prayer enters clinical contexts and 2) how physicians respond. METHODS: We examined in-depth interviews with 30 academic pediatricians and pediatric oncologists.

Author(s): 
Cadge, Wendy
Ecklund, Elaine Howard
Publication Title: 
BMC bioinformatics

BACKGROUND: Microarrays permit biologists to simultaneously measure the mRNA abundance of thousands of genes. An important issue facing investigators planning microarray experiments is how to estimate the sample size required for good statistical power. What is the projected sample size or number of replicate chips needed to address the multiple hypotheses with acceptable accuracy? Statistical methods exist for calculating power based upon a single hypothesis, using estimates of the variability in data from pilot studies.

Author(s): 
Page, Grier P.
Edwards, Jode W.
Gadbury, Gary L.
Yelisetti, Prashanth
Wang, Jelai
Trivedi, Prinal
Allison, David B.
Publication Title: 
The American Journal of Psychiatry

OBJECTIVE: The authors examined the safety and efficacy of long-term fluoxetine monotherapy, lithium monotherapy, and placebo therapy in preventing relapse and recurrence of bipolar type II major depressive episode. The authors hypothesized that fluoxetine monotherapy would be superior to lithium monotherapy with a similar hypomanic mood conversion rate.

Author(s): 
Amsterdam, Jay D.
Shults, Justine
Publication Title: 
Statistics in Medicine

OBJECTIVE: To investigate major methods of design and statistical analysis in controlled clinical acupuncture trials published in the West during the past six years (2003-2009) and, based on this analysis, to provide recommendations that address methodological issues and challenges in clinical acupuncture research. METHOD: PubMed was searched for acupuncture RCTs published in Western journals in English between 2003 and 2009. The keyword used was acupuncture.

Author(s): 
Shuai, Ping
Zhou, Xiao-Hua
Lao, Lixing
Li, Xiaosong
Publication Title: 
Brain, Behavior, and Immunity

Observational studies have linked lower omega-3 (n-3) polyunsaturated fatty acids (PUFAs) and higher omega-6 (n-6) PUFAs with inflammation and depression, but randomized controlled trial (RCT) data have been mixed. To determine whether n-3 decreases proinflammatory cytokine production and depressive and anxiety symptoms in healthy young adults, this parallel group, placebo-controlled, double-blind 12-week RCT compared n-3 supplementation with placebo. The participants, 68 medical students, provided serial blood samples during lower-stress periods as well as on days before an exam.

Author(s): 
Kiecolt-Glaser, Janice K.
Belury, Martha A.
Andridge, Rebecca
Malarkey, William B.
Glaser, Ronald
Publication Title: 
The Clinical Journal of Pain

OBJECTIVES: To compare naprapathic manual therapy with evidence-based care for back or neck pain regarding pain, disability, and perceived recovery. Naprapathy that is common in the Nordic countries and in some states in the United States is characterized by manual manipulations with a focus on soft and connective tissues, aiming to decrease pain and disability in the musculoskeletal system.

Author(s): 
Skillgate, Eva
Vingård, Eva
Alfredsson, Lars
Publication Title: 
Trials

BACKGROUND: Low back pain (LBP) is a major health problem in modern society, with 70-85% of the population experiencing LBP at some time in their lives. Each year, 5-10% of the workforce misses work due to LBP, most for less than 7 days. Almost 10% of all patients are at risk of developing chronic pain and disability. Little clinical evidence is available for the majority of treatments used in LBP therapy. However, moderate evidence exists for interdisciplinary rehabilitation, exercise, acupuncture, spinal manipulation, and cognitive behavioral therapy for subacute and chronic LBP.

Author(s): 
Buselli, Paolo
Bosoni, Roberto
Busè, Gabriella
Fasoli, Paola
La Scala, Elide
Mazzolari, Rita
Zanetti, Federica
Messina, Sara

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