Sample Size

Publication Title: 
British Journal of Clinical Pharmacology

AIMS: Homeopathic medicines are frequently purchased over the counter (OTC). Respiratory complaints are the most frequent reason for such purchases. Children with upper respiratory tract infection (URTI) are frequent users of homeopathy. This study investigates the effect of self treatment with one of three self selected ultramolecular homeopathic medicines for the prevention of childhood URTI.

Author(s): 
Steinsbekk, Aslak
Bentzen, Niels
Fønnebø, Vinjar
Lewith, George
Publication Title: 
Trials

BACKGROUND: This study protocol adapts the traditional homeopathic drug proving methodology to a modern clinical trial design. METHOD: Multi-centre, randomised, double-blind, placebo-controlled phase 1 trial with 30 healthy volunteers. The study consists of a seven day run-in period, a five day intervention period and a 16 day post-intervention observation period. Subjects, investigators and the statisticians are blinded from the allocation to the study arm and from the identity of the homeopathic drug.

Author(s): 
Teut, Michael
Hirschberg, Ute
Luedtke, Rainer
Schnegg, Cristoph
Dahler, Joern
Albrecht, Henning
Witt, Claudia M.
Publication Title: 
Trials

BACKGROUND: Homeopathy is often sought by patients with depression. In classical homeopathy, the treatment consists of two main elements: the case history and the prescription of an individually selected homeopathic remedy. Previous data suggest that individualized homeopathic Q-potencies were not inferior to the antidepressant fluoxetine in a sample of patients with moderate to severe depression.

Author(s): 
Adler, Ubiratan C.
Krüger, Stephanie
Teut, Michael
Lüdtke, Rainer
Bartsch, Iris
Schützler, Lena
Melcher, Friedericke
Willich, Stefan N.
Linde, Klaus
Witt, Claudia M.
Publication Title: 
The Journal of Clinical Psychiatry

OBJECTIVE: To systematically review placebo-controlled randomized trials of homeopathy for psychiatric conditions. DATA SOURCES: Eligible studies were identified using the following databases from database inception to April 2010: PubMed, CINAHL, PsycINFO, Hom-Inform, Cochrane CENTRAL, National Center for Complementary and Alternative Medicine grantee publications database, and ClinicalTrials.gov.

Author(s): 
Davidson, Jonathan R. T.
Crawford, Cindy
Ives, John A.
Jonas, Wayne B.
Publication Title: 
Vaccine

Negative studies of vaccine adverse events occur with some frequency in the published literature. They serve important roles in fending off claims posed by the anti-vaccine movement and in reinforcing public health efforts to prevent diseases. Still, negative studies frequently suffer from concerns of adequate sample size. The double-significance Neyman-Pearson formula for sample size calculation that is now in vogue results in immense sample sizes that can lead to illogical interpretations. The late Professor Alvan R.

Author(s): 
Jacobson, Robert M.
Poland, Gregory A.
Publication Title: 
Trials

BACKGROUND: Treatment with Androgen Deprivation Therapy (ADT) for prostate cancer is associated with changes in body composition including increased fat and decreased lean mass; increased fatigue, and a reduction in quality of life. No study to date has evaluated the effect of dietary and physical activity modification on the side-effects related to ADT.

Author(s): 
Haseen, Farhana
Murray, Liam J.
O'Neill, Roisin F.
O'Sullivan, Joe M.
Cantwell, Marie M.
Publication Title: 
Trials

BACKGROUND: Treatment with Androgen Deprivation Therapy (ADT) for prostate cancer is associated with changes in body composition including increased fat and decreased lean mass; increased fatigue, and a reduction in quality of life. No study to date has evaluated the effect of dietary and physical activity modification on the side-effects related to ADT.

Author(s): 
Haseen, Farhana
Murray, Liam J.
O'Neill, Roisin F.
O'Sullivan, Joe M.
Cantwell, Marie M.
Publication Title: 
Spine

STUDY DESIGN: A blinded, randomized controlled trial was conducted. OBJECTIVE: To test the hypothesis that chiropractic side-posture manipulation (adjusting) of the lumbar spine separates (gaps) the zygapophysial (Z) joints. SUMMARY OF BACKGROUND DATA: Spinal adjusting is thought to gap the Z joints, yet no studies have conclusively validated this hypothesis, and some investigators have reported that the lumbar Z joints do not gap during rotation.

Author(s): 
Cramer, Gregory D.
Gregerson, Douglas M.
Knudsen, J. Todd
Hubbard, Bradley B.
Ustas, Leah M.
Cantu, Joe A.
Publication Title: 
Spine

STUDY DESIGN: Double-blind, randomized, placebo-controlled trial. OBJECTIVES: To evaluate the effect of manual endplay assessment on neck pain and stiffness outcomes in neck pain patients receiving spinal manipulation. SUMMARY OF THE BACKGROUND DATA: There have been no studies on the efficacy of palpation used as an indicator for manipulation in the management of back and neck pain. METHODS: Neck pain patients (n = 104) were randomly assigned to two groups.

Author(s): 
Haas, Mitchell
Groupp, Elyse
Panzer, David
Partna, Lester
Lumsden, Steve
Aickin, Mikel
Publication Title: 
Spine

STUDY DESIGN: A blinded, randomized controlled trial was conducted. OBJECTIVE: To test the hypothesis that chiropractic side-posture manipulation (adjusting) of the lumbar spine separates (gaps) the zygapophysial (Z) joints. SUMMARY OF BACKGROUND DATA: Spinal adjusting is thought to gap the Z joints, yet no studies have conclusively validated this hypothesis, and some investigators have reported that the lumbar Z joints do not gap during rotation.

Author(s): 
Cramer, Gregory D.
Gregerson, Douglas M.
Knudsen, J. Todd
Hubbard, Bradley B.
Ustas, Leah M.
Cantu, Joe A.

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