Treatment Outcome

Publication Title: 
Cancer

BACKGROUND: Among patients with well differentiated papillary thyroid carcinoma who generally have an excellent prognosis and a near-normal lifespan, there exist subsets of patients who have significant risk for morbidity and mortality from this disease. It is important to define the patterns of disease progression and the clinical outcome of such patients to develop effective surveillance and treatment strategies.

Author(s): 
Vassilopoulou-Sellin, R.
Schultz, P. N.
Haynie, T. P.
Publication Title: 
International Journal of Radiation Oncology, Biology, Physics

PURPOSE: To investigate the feasibility, toxicity, cosmetic outcome, and local control of high-dose-rate (HDR) brachytherapy alone without whole breast external beam irradiation for early-stage breast carcinoma. METHODS AND MATERIALS: Between June 1997 and August 1999, 32 women diagnosed with a total of 33 AJCC Stage I/II breast carcinomas underwent surgical breast excision and postoperative irradiation using HDR brachytherapy interstitial implantation as part of a multi-institutional clinical Phase I/II protocol.

Author(s): 
Wazer, David E.
Berle, Lisa
Graham, Roger
Chung, Maureen
Rothschild, Janice
Graves, Theresa
Cady, Blake
Ulin, Kenneth
Ruthazer, Robin
DiPetrillo, Thomas A.
Publication Title: 
Journal of Clinical Psychopharmacology

Antidepressant continuation studies have used 2 different designs. In the placebo substitution design, all patients are initially treated with active medication in an open-label fashion, and then treatment responders are randomized to continue with medication or switch to placebo in a double-blind manner. In the extension design, patients are randomized to a double-blind placebo-controlled acute study at the outset, and responders to active treatment and placebo are continued on the treatment to which they initially responded.

Author(s): 
Zimmerman, Mark
Posternak, Michael A.
Ruggero, Camilo J.
Publication Title: 
Coronary Artery Disease

Percutaneous pulmonary valve implantation helps in prolonging the lifespan of surgically placed right ventricle-to-pulmonary artery (RV-PA) conduits, and represents a less invasive alternative to repeat open-heart surgery. The clinical indications for treatment match those of surgery. As far as the suitability is concerned, the current ideal substrate is a degenerated RV-PA conduit, because of the presence of a certain degree of calcification that offers a safe anchoring point.

Author(s): 
Frigiola, Alessandra
Nordmeyer, Johannes
Bonhoeffer, Philipp
Publication Title: 
Clinical Orthopaedics and Related Research

BACKGROUND: Orthopaedic oncologists often must address leg-length discrepancy after resection of tumors in growing patients with osteosarcoma. There are various alternatives to address this problem. We describe a three-stage procedure: (1) temporary arthrodesis, (2) lengthening by Ilizarov apparatus, and (3) tumor prosthesis.

Author(s): 
Kong, Chang-Bae
Lee, Soo-Yong
Jeon, Dae-Geun
Publication Title: 
European journal of human genetics: EJHG

Spinal muscular atrophy (SMA) is the leading genetic cause of early childhood death worldwide and no therapy is available today. Many drugs, especially histone deacetylase inhibitors (HDACi), increase SMN levels. As all HDACi tested so far only mildly ameliorate the SMA phenotype or are unsuitable for use in humans, there is still need to identify more potent drugs. Here, we assessed the therapeutic power of the pan-HDACi JNJ-26481585 for SMA, which is currently used in various clinical cancer trials.

Author(s): 
Schreml, Julia
Riessland, Markus
Paterno, Mario
Garbes, Lutz
Roflbach, Kristina
Ackermann, Bastian
Kr‰mer, Jan
Somers, Eilidh
Parson, Simon H.
Heller, Raoul
Berkessel, Albrecht
Sterner-Kock, Anja
Wirth, Brunhilde
Publication Title: 
Revue De Chirurgie OrthopÈdique Et RÈparatrice De L'appareil Moteur

We report an illustrative case of bilateral Moore arthroplasty with the clinical and radiographic results at 36 years follow-up. The femoral prostheses were implanted for necrosis of the femoral head when the patient was 46 years old. At implantation the patient's physical activity level was high (Devane 4) and remained so until retirement at age 65 years. His activity level remained high (Devane 3) to the age of 82 years when the patient suffered a Vancouver B1 periprosthetic fracture on the left. At this date, both arthroplasties were free of loosening an osteolysis.

Author(s): 
Marchetti, E.
Bachour, F.
Girard, J.
May, O.
Migaud, H.
Laffargue, P.
Publication Title: 
Instructional Course Lectures

Cementless femoral fixation has been established as the gold standard for hip arthroplasty in young patients because of its exceptional longevity. Because older Americans are living longer and staying active, cementless femoral fixation for hip arthroplasty should be considered in all patients who have good bone quality. Numerous studies have shown excellent results using cementless fixation for hip arthroplasty in elderly patients. Histologic analysis, radiographic review, and dual-energy x-ray absorptiometry have shown solid osseointegration for biologic fixation and minimal bone loss.

Author(s): 
Dutton, Andrew
Rubash, Harry E.
Publication Title: 
International Orthopaedics

Total knee replacement (TKR) achieves an immediate and exceptional restoration in the quality of life that is comparable only to a few other procedures. It has been suggested that the most common cause of revision TKR is error in surgical technique, from malpositioning of the components which results in a poorer post-operative outcome. Based on the theoretical assumption that the use of computer-assisted systems (CAS) in TKRs may improve implant alignment and thus implant longevity, the use of this technology is becoming increasingly popular.

Author(s): 
Dattani, Rupen
Patnaik, Surendra
Kantak, Avadhoot
Tselentakis, Georgis
Publication Title: 
Scandinavian Journal of Medicine & Science in Sports

This consensus statement summarizes key contemporary research themes relevant to understanding the psychology and socioculture of sport injury. Special consideration is given toward high-intensity sport in which elite athlete training and performance efforts are characterized by explosive physical speed and strength, mental fortitude to push physical limits, and maximum effort and commitment to highly challenging goals associated with achieving exceptional performance.

Author(s): 
Wiese-Bjornstal, D. M.

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