Absorption

Publication Title: 
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy

Biologically inspired experimental process in synthesising nanoparticles is of great interest in present scenario. Biosynthesis of nanoparticles is considered to be one of the best green techniques in synthesising metal nanoparticles. Here, an in situ green biogenic synthesis of gold nanoparticles using aqueous extracts of Terminalia chebula as reducing and stabilizing agent is reported. Gold nanoparticles were confirmed by surface plasmon resonance in the range of 535 nm using UV-visible spectrometry.

Author(s): 
Kumar, Kesarla Mohan
Mandal, Badal Kumar
Sinha, Madhulika
Krishnakumar, Varadhan
Publication Title: 
Annual Review of Nutrition
Author(s): 
Emken, E. A.
Publication Title: 
British Journal of Clinical Pharmacology

1. The pharmacokinetic and effect kinetic properties of oral (p.o.), intramuscular (i.m.), and intrarectal (i.r.) artemether (5 mg kg-1) were compared in a crossover study in eight healthy adult volunteers. Plasma concentrations of artemether (AM) and its active metabolite dihydroartemisinin (DHA) were measured by high performance liquid chromatography with reductive mode electrochemical detection (h.p.l.c.-ECD), and plasma antimalarial activity in vitro (effect) was assessed on the same samples by a sensitive bioassay (BA). 2.

Author(s): 
Teja-Isavadharm, P.
Nosten, F.
Kyle, D. E.
Luxemburger, C.
ter Kuile, F.
Peggins, J. O.
Brewer, T. G.
White, N. J.
Publication Title: 
The American Journal of Tropical Medicine and Hygiene

A thermostable suppository of artesunate (artesunic acid) has been developed. In Gabon, 12 children with Plasmodium falciparum malaria received two administrations of this suppository in a 4-hr interval. Parasitemia and fever were then measured and the plasma levels of artesunate and its active metabolite, dihydroartemisinin, were determined by means of a reversed phase high-pressure liquid chromatography method using reductive electrochemical detection.

Author(s): 
Halpaap, B.
Ndjave, M.
Paris, M.
Benakis, A.
Kremsner, P. G.
Publication Title: 
Tropical medicine & international health: TM & IH

BACKGROUND: Artemether-lumefantrine (AL) is the only fixed, artemisinin-based combination antimalarial drug which is registered internationally and deployed on a large scale. Absorption of the hydrophobic lipophilic lumefantrine component varies widely between individuals and is greatly increased by fat coadministration; but patients with acute malaria are frequently nauseated and anorexic, making dietary advice difficult to comply with.

Author(s): 
Ashley, Elizabeth A.
Stepniewska, Kasia
Lindegardh, Niklas
Annerberg, Anna
Kham, Am
Brockman, Al
Singhasivanon, Pratap
White, Nicholas J.
Nosten, François
Publication Title: 
Tropical medicine & international health: TM & IH

BACKGROUND: Adherence to antimalarial drug regimens is improved by simple dosing. If the fixed antimalarial drug combination artemether-lumefantrine (AL) could be given once daily, this should improve adherence and thus effectiveness and lower the risk of selecting for resistance. METHODS: In an open randomized study, 43 patients with uncomplicated falciparum malaria were given equivalent doses of AL with 200 ml flavoured milk either as the conventional twice-daily regimen or as a single daily dose for 3 days.

Author(s): 
Ashley, Elizabeth A.
Stepniewska, Kasia
Lindegardh, Niklas
McGready, Rose
Annerberg, Anna
Hutagalung, Robert
Singtoroj, Thida
Hla, Gilvary
Brockman, Al
Proux, Stephane
Wilahphaingern, Jahser
Singhasivanon, Pratap
White, Nicholas J.
Nosten, François
Publication Title: 
Talanta

Synergistic liquid-liquid extractive spectrophotometric determination of gold(III) using 1-(2',4'-dinitro aminophenyl)-4,4,6-trimethyl-1,4-dihydro pyrimidine-2-thiol [2',4'-dinitro APTPT] has been described. Equal volumes (5cm(3)) of the 2',4'-dinitro APTPT (0.02molL(-1)) in the presence of pyridine (0.5molL(-1)) form an orange-red coloured ternary complex with gold(III) of molar ratio 1:1:1 at pH 1.8-2.4 with 5min of shaking. The absorbance of coloured organic layer in 1,2-dichloroethane is measured spectrophotometrically at 445nm against reagent blank.

Author(s): 
Kamble, Ganesh S.
Kolekar, Sanjay S.
Han, Sung H.
Anuse, Mansing A.
Publication Title: 
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy

The development of new synthesis methods for monodispersed nanocrystals using cheap and nontoxic chemicals, environmentally benign solvents and renewable materials remains a challenge to the scientific community. The present work reports a new green method for the synthesis of gold nanoparticles. Four different ayurvedic arishtams are used for the reduction of Au(3+) to Au nanoparticles. This method is simple, efficient, economic and nontoxic. Gold nanoparticles having different sizes in the range from 15 to 23 nm could be obtained.

Author(s): 
Aromal, S. Aswathy
Babu, K. V. Dinesh
Philip, Daizy
Publication Title: 
Bioelectromagnetics

The aim of the present study was to determine millimeter wave (MMW) absorption by blood vessels traversing the subcutaneous fat layer of murine skin. Most calculations were performed using the finite-difference time-domain (FDTD) technique. We used two types of models: (1) a rectangular block of multilayer tissue with blood vessels traversing the fat layer and (2) cylindrical models with circular and elliptical cross-sections simulating the real geometry of murine limbs.

Author(s): 
Alekseev, Stanislav I.
Ziskin, Marvin C.
Publication Title: 
Drug Metabolism and Disposition: The Biological Fate of Chemicals

Nonalcoholic fatty liver disease (NAFLD) is characterized by a series of pathological changes that range from simple fatty liver to nonalcoholic steatohepatitis (NASH). The objective of this study is to describe changes in global gene expression associated with the progression of human NAFLD. This study is focused on the expression levels of genes responsible for the absorption, distribution, metabolism, and elimination (ADME) of drugs. Differential gene expression between three clinically defined pathological groups-normal, steatosis, and NASH-was analyzed.

Author(s): 
Lake, April D.
Novak, Petr
Fisher, Craig D.
Jackson, Jonathan P.
Hardwick, Rhiannon N.
Billheimer, D. Dean
Klimecki, Walter T.
Cherrington, Nathan J.

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