Animals, Genetically Modified

Publication Title: 
Cell Metabolism

A common thread among conserved life span regulators lies within intertwined roles in metabolism and energy homeostasis. We show that heterozygous mutations of AMP biosynthetic enzymes extend Drosophila life span. The life span benefit of these mutations depends upon increased AMP:ATP and ADP:ATP ratios and adenosine monophosphate-activated protein kinase (AMPK). Transgenic expression of AMPK in adult fat body or adult muscle, key metabolic tissues, extended life span, while AMPK RNAi reduced life span.

Stenesen, Drew
Suh, Jae Myoung
Seo, Jin
Yu, Kweon
Lee, Kyu-Sun
Kim, Jong-Seok
Min, Kyung-Jin
Graff, Jonathan M.
Publication Title: 

Cocaine- and amphetamine-regulated transcript (CART) is a hypothalamic neuropeptide implicated in both metabolic and reproductive regulation, raising the possibility that CART plays a role in reproductive inhibition during negative metabolic conditions. The current study characterized CART's regulatory influence on GnRH and kisspeptin (Kiss1) cells and determined the sensitivity of different CART populations to negative energy balance.

True, Cadence
Verma, Saurabh
Grove, Kevin L.
Smith, M. Susan
Publication Title: 
Biological & Pharmaceutical Bulletin

SuHeXiang Wan (SHXW), a Chinese traditional medicine, has been used to treat infantile convulsions, seizures and strokes. Previously, we reported that modified SHXW, called KSOP1009, suppressed the hyper-activation of c-Jun N-terminal kinase (JNK) and Alzheimer's disease (AD)-like phenotypes in amyloid-β42 (Aβ42)-expressing Drosophila AD models. In the present study, we, further, investigated the detailed mechanism by which KSOP1009 suppresses the AD-like phenotypes of the model flies.

Park, Seung Hwan
Lee, Soojin
Hong, Yoon Ki
Hwang, Soojin
Lee, Jang Ho
Bang, Se Min
Kim, Young-Kyoon
Koo, Byung-Soo
Lee, Im-Soon
Cho, Kyoung Sang
Publication Title: 
Neurobiology of Disease

C. elegans and D. rerio expressing mutant TAR DNA Binding Protein 43 (TDP-43) are powerful in vivo animal models for the genetics and pharmacology of amyotrophic lateral sclerosis (ALS). Using these small-animal models of ALS, we previously identified methylene blue (MB) as a potent suppressor of TDP-43 toxicity. Consequently here we investigated how MB might exert its neuroprotective properties and found that it acts through reduction of the endoplasmic reticulum (ER) stress response.

Vaccaro, Alexandra
Patten, Shunmoogum A.
Aggad, Dina
Julien, Carl
Maios, Claudia
Kabashi, Edor
Drapeau, Pierre
Parker, J. Alex


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