Gamma Rays

Publication Title: 
Mutation Research

Human diploid fibroblasts, strain MRC-5, were sequentially irradiated with 60Co gamma rays at intervals during their in vitro lifespan. The results indicate that 3 or 6 doses of 1 Gy can increase lifespan, and the same was true for cells treated with 3 doses of 3 Gy. Higher doses (5 x 3 Gy) did reduce growth potential, suggesting either that mid-late passage cells become more sensitive to radiation, or that doses beyond a given threshold reduce population lifespan by multiple cellular hits. The life extension induced by gamma rays might be due to an induced hypermethylation of DNA.

Author(s): 
Holliday, R.
Publication Title: 
International Journal of Oncology

Retroviral infection of hTERT, the catalytic component of telomerase, into BJ fibroblasts (population doubling 28) resulted in reconstitution of telomerase activity, telomere maintenance, and extension of in vitro lifespan. The hTERT-infected cells also exhibited increased growth rate and colony forming efficiency relative to controls, while remaining contact-inhibited and maintaining a p53-mediated damage response following gamma-irradiation.

Author(s): 
Forsythe, Heidi L.
Elmore, Lynne W.
Jensen, Keith O.
Landon, Melissa R.
Holt, Shawn E.
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

The effects of 10 mg/kg of triphala extract (TE) was studied on radiation-induced sickness and mortality in mice exposed to 7-12 Gray (Gy) of gamma-irradiation. Treatment of mice with triphala once daily for 5 consecutive days before irradiation delayed the onset of mortality and reduced the symptoms of radiation sickness when compared with the non-drug double distilled water treated irradiated controls (DDW). Triphala provided protection against both gastrointestinal and hemopoetic death.

Author(s): 
Jagetia, Ganesh Chandra
Malagi, Krishna J.
Baliga, Manjeshwar Shrinath
Venkatesh, Ponemone
Veruva, Rosi Reddy
Publication Title: 
Phytomedicine: International Journal of Phytotherapy and Phytopharmacology

The effect of 0, 5, 6.25, 10, 12.5, 20, 25, 40, 50 and 80 mg/kg b. wt. of aqueous extract of triphala (an Ayurvedic herbal medicine) administrered intraperitoneally was studied on the radiation-induced mortality in mice exposed to 10 Gy of gamma-radiation. Treatment of mice with different doses of triphala consecutively for five days before irradiation delayed the onset of mortality and reduced the symptoms of radiation sickness when compared with the non-drug treated irradiated controls.

Author(s): 
Jagetia, G. C.
Baliga, M. S.
Malagi, K. J.
Sethukumar Kamath, M.
Publication Title: 
Die Nahrung

The effect of 5, 10, 20, 40, 60, 80, 100, 120, and 160 mg/kg body weight (b.wt.) of aqueous extract of cystone (an ayurvedic herbal medicine) administered intraperitoneally was studied on the radiation-induced mortality in mice exposed to 10 Gy of gamma-radiation. Treatment of mice with different doses of cystone, consecutively for five days before irradiation, delayed the onset of mortality and reduced the symptoms of radiation sickness when compared with the non-drug treated irradiated controls.

Author(s): 
Jagetia, Ganesh Chandra
Baliga, Manjeshwar Shrinath
Publication Title: 
Phytochemistry

Four aqueous extracts from different parts of medicinal plants used in Ayurveda (an ancient Indian Medicine) viz., Momardica charantia Linn (AP1), Glycyrrhiza glabra (AP2), Acacia catechu (AP3), and Terminalia chebula (AP4) were examined for their potential as antioxidants. The antioxidant activity of these extracts was tested by studying the inhibition of radiation induced lipid peroxidation in rat liver microsomes at different doses in the range of 100-600 Gy as estimated by thiobarbituric acid reactive substances (TBARS).

Author(s): 
Naik, G. H.
Priyadarsini, K. I.
Satav, J. G.
Banavalikar, M. M.
Sohoni, D. P.
Biyani, M. K.
Mohan, H.
Publication Title: 
Phytotherapy research: PTR

Tinospora cordifolia is widely used in Ayurvedic medicines. It is known for its immunomodulatory, antihepatotoxic, antistress and antioxidant properties. It has been used in combination with other plant products to prepare a number of Ayurvedic preparations. The present study was undertaken to evaluate the radioprotective effect of an aqueous extract of Tinospora cordifolia (TC) against (60)Co gamma radiation.

Author(s): 
Pahadiya, Subhash
Sharma, Jaimala
Publication Title: 
Phytotherapy research: PTR

The effect of various doses of 50% ethanolic extract of chyavanaprasha (an Ayurvedic rejuvenating herbal preparation) was studied on the survival of mice exposed to 10 Gy of gamma-radiation. Treatment with chyavanaprasha, consecutively for fi ve days before irradiation, delayed symptoms of radiation sickness and onset of mortality when compared with the non-drug treated irradiated controls.

Author(s): 
Jagetia, Ganesh Chandra
Baliga, Manjeshwar Shrinath
Publication Title: 
The American Journal of Chinese Medicine

The effect of 5, 10, 20, 40 and 80 mg/kg b. wt. of hydroalcoholic extract of geriforte (an Ayurvedic herbal medicine) administered intraperitoneally was studied on the radiation-induced mortality in mice exposed to 10 Gy of gamma-radiation. Treatment of mice with different doses of geriforte consecutively for 5 days before irradiation delayed the onset of mortality and reduced the symptoms of radiation sickness when compared with the non-drug treated irradiated controls.

Author(s): 
Jagetia, Ganesh Chandra
Baliga, Manjeshwar Shrinath
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

The effects of 10 mg/kg of triphala extract (TE) was studied on radiation-induced sickness and mortality in mice exposed to 7-12 Gray (Gy) of gamma-irradiation. Treatment of mice with triphala once daily for 5 consecutive days before irradiation delayed the onset of mortality and reduced the symptoms of radiation sickness when compared with the non-drug double distilled water treated irradiated controls (DDW). Triphala provided protection against both gastrointestinal and hemopoetic death.

Author(s): 
Jagetia, Ganesh Chandra
Malagi, Krishna J.
Baliga, Manjeshwar Shrinath
Venkatesh, Ponemone
Veruva, Rosi Reddy

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