Mice

Publication Title: 
PloS One

Electroacupuncture (EA) is a novel therapy based on traditional acupuncture combined with modern eletrotherapy that is currently being investigated as a treatment for acute ischemic stroke. Here, we studied whether acute EA stimulation improves tissue and functional outcome following experimentally induced cerebral ischemia in mice. We hypothesized that endothelial nitric oxide synthase (eNOS)-mediated perfusion augmentation was related to the beneficial effects of EA by interventions in acute ischemic injury.

Author(s): 
Kim, Ji Hyun
Choi, Kyung Ha
Jang, Young Jung
Bae, Sun Sik
Shin, Byung-Cheul
Choi, Byung Tae
Shin, Hwa Kyoung
Publication Title: 
PloS One

Bee venom has recently been suggested to possess beneficial effects in the treatment of Parkinson disease (PD). For instance, it has been observed that bilateral acupoint stimulation of lower hind limbs with bee venom was protective in the acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD. In particular, a specific component of bee venom, apamin, has previously been shown to have protective effects on dopaminergic neurons in vitro. However, no information regarding a potential protective action of apamin in animal models of PD is available to date.

Author(s): 
Alvarez-Fischer, Daniel
Noelker, Carmen
Vulinović, Franca
Grünewald, Anne
Chevarin, Caroline
Klein, Christine
Oertel, Wolfgang H.
Hirsch, Etienne C.
Michel, Patrick P.
Hartmann, Andreas
Publication Title: 
Journal of Neuroinflammation

BACKGROUND: Emerging studies have demonstrated that pretreatment with electroacupuncture (EA) induces significant tolerance to focal cerebral ischemia. The present study seeks to determine the involvement of monocyte chemotactic protein-induced protein 1 (MCPIP1), a recently identified novel modulator of inflammatory reactions, in the cerebral neuroprotection conferred by EA pretreatment in the animal model of focal cerebral ischemia and to elucidate the mechanisms of EA pretreatment-induced ischemic brain tolerance.

Author(s): 
Jin, Zhuqing
Liang, Jian
Wang, Jing
Kolattukudy, Pappachan E.
Publication Title: 
PloS One

Bradykinesia is one of the major clinical symptoms of Parkinson`s disease (PD) for which treatment is sought. In most mouse models of PD, decreased locomotor activity can be reflected in an open field behavioral test. Therefore the open field test provides a useful tool to study the clinic symptoms of PD patients. Our previous work demonstrated that 100 Hz electro-acupuncture (EA) stimulation at ZUSANLI and SANYINJIAO protected the dopaminergic nigrostriatal system of C57BL/6 mice from MPTP toxicity, indicating that acupuncture might be an effective therapy for PD sufferers.

Author(s): 
Wang, Haomin
Liang, Xibin
Wang, Xuan
Luo, Dingzhen
Jia, Jun
Wang, Xiaomin
Publication Title: 
Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan / Sponsored by All-China Association of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine

OBJECTIVE: This work aims to observe the effects of electroacupuncture on brain-derived neurotrophic factor (BDNF) mRNA expression in mouse hippocampus following cerebral ischemia-reperfusion injury. METHODS: The models of mouse cerebral ischemia-reperfusion injury were established. A total of 96 healthy mice were randomly assigned into 4 groups, namely, the sham surgery, model, model + electroacupuncture, and mode + hydergine groups. Mice in the model + electroacupuncture group were treated through electroacupuncture at the Shenshu (BL 23), Geshu (BL 17), and Baihui (GV 20) acupoints.

Author(s): 
Zhao, Jianxin
Xu, Huazhou
Tian, Yuanxiang
Hu, Manxiang
Xiao, Hongling
Publication Title: 
PloS One

Hippocampal neurons play a critical role in learning and memory; however, the effects of environmental mechanical forces on neurite extension and associated underlying mechanisms are largely unexplored, possibly due to difficulties in maintaining central nervous system neurons. Neuron adhesion, neurite length, and mechanotransduction are mainly influenced by the extracellular matrix (ECM), which is often associated with structural scaffolding.

Author(s): 
Chen, Wei-Hsin
Cheng, Sin-Jhong
Tzen, Jason T. C.
Cheng, Chao-Min
Lin, Yi-Wen
Publication Title: 
Nature Medicine

Previous anti-inflammatory strategies against sepsis, a leading cause of death in hospitals, had limited efficacy in clinical trials, in part because they targeted single cytokines and the experimental models failed to mimic clinical settings. Neuronal networks represent physiological mechanisms, selected by evolution to control inflammation, that can be exploited for the treatment of inflammatory and infectious disorders. Here, we report that sciatic nerve activation with electroacupuncture controls systemic inflammation and rescues mice from polymicrobial peritonitis.

Author(s): 
Torres-Rosas, Rafael
Yehia, Ghassan
Peña, Geber
Mishra, Priya
del Rocio Thompson-Bonilla, Maria
Moreno-Eutimio, Mario Adán
Arriaga-Pizano, Lourdes Andrea
Isibasi, Armando
Ulloa, Luis
Publication Title: 
The Journal of Neuroscience: The Official Journal of the Society for Neuroscience

14-3-3 is a family of regulatory proteins highly expressed in the brain. Previous invertebrate studies have demonstrated the importance of 14-3-3 in the regulation of synaptic functions and learning and memory. However, the in vivo role of 14-3-3 in these processes has not been determined using mammalian animal models. Here, we report the behavioral and electrophysiological characterization of a new animal model of 14-3-3 proteins. These transgenic mice, considered to be a 14-3-3 functional knock-out, express a known 14-3-3 inhibitor in various brain regions of different founder lines.

Author(s): 
Qiao, Haifa
Foote, Molly
Graham, Kourtney
Wu, Yuying
Zhou, Yi

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