Pregnancy

Publication Title: 
Gynecologic and Obstetric Investigation

Abortion, primarily as a measure of population control, certainly continues to be an emotional, frustrating and stressful event. In continuation of our work on stressful situations in the female life span and biochemical parameters, serum lipid peroxide levels in terms of malondialdehyde (nmol/ml) have been determined in females undergoing abortion [suction curettage (n = 30), Emcredil-induced abortion (n = 30) and spontaneous abortion (n = 40)] and were compared with appropriate gestational controls.

Author(s): 
Sane, A. S.
Chokshi, S. A.
Mishra, V. V.
Barad, D. P.
Shah, V. C.
Nagpal, S.
Publication Title: 
Endocrine Reviews

Menopause is the final step in the process referred to as ovarian ageing. The age related decrease in follicle numbers dictates the onset of cycle irregularity and the final cessation of menses. The parallel decay in oocyte quality contributes to the gradual decline in fertility and the final occurrence of natural sterility. Endocrine changes mainly relate to the decline in the negative feedback from ovarian factors at the hypothalamo-pituitary unit.

Author(s): 
Broekmans, F. J.
Soules, M. R.
Fauser, B. C.
Publication Title: 
BMC pregnancy and childbirth

BACKGROUND: A longitudinal repeated measures design over pregnancy and post-birth, with a control group would provide insight into the mechanical adaptations of the body under conditions of changing load during a common female human lifespan condition, while minimizing the influences of inter human differences.

Author(s): 
Gilleard, Wendy L.
Publication Title: 
American Journal of Medical Genetics

We report on 2 unusual cases of the campomelic syndrome, the first being a fetus in whom the diagnosis was suspected in the 18th week and confirmed sonographically at 20 weeks. The second case concerns a 5 year old 46, XY girl with an exceptional longevity and a relatively favorable evolution.

Author(s): 
Gillerot, Y.
Vanheck, C. A.
Foulon, M.
Podevain, A.
Koulischer, L.
Publication Title: 
American Journal of Human Biology: The Official Journal of the Human Biology Council

Frontier populations provide exceptional opportunities to test the hypothesis of a trade-off between fertility and longevity. In such populations, mechanisms favoring reproduction usually find fertile ground, and if these mechanisms reduce longevity, demographers should observe higher postreproductive mortality among highly fertile women.

Author(s): 
Gagnon, Alain
Smith, Ken R.
Tremblay, Marc
VÈzina, HÈlËne
ParÈ, Paul-Philippe
Desjardins, Bertrand
Publication Title: 
Methods in Molecular Biology (Clifton, N.J.)

Intrauterine gene therapy (IUGT) potentially enables the treatment and possible cure of monogenic -diseases that cause severe fetal damage. The main benefits of this approach will be the ability to correct the disorder before the onset of irreversible pathology and inducing central immune tolerance to the vector and transgene if treatment is instituted in early gestation.

Author(s): 
Mattar, Citra N.
Biswas, Arijit
Choolani, Mahesh
Chan, Jerry K. Y.
Publication Title: 
Journal of Reproductive Immunology

The transfer and persistence of fetal progenitor cells into the mother throughout pregnancy has sparked considerable interest as a trafficking stem cell and immunological phenomenon. Indeed, the intriguing longevity of semi-allogeneic fetal microchimeric cells (FMC) in parous women raises questions over their potential clinical implications. FMC have been associated with both immune-modulatory roles and participation in maternal tissue repair.

Author(s): 
Seppanen, E.
Fisk, N. M.
Khosrotehrani, K.
Publication Title: 
The American Journal of Clinical Nutrition
Author(s): 
Roeder, L. M.
Publication Title: 
Medical Hypotheses

Anorexia nervosa was explored as the possible expression of an aberration of the processing of information which ordinarily has value in life protection or extension. Each of 6 areas was briefly reviewed, and noted to have the potential for failure to balance 2 or more factors. Anorexia nervosa may prove to be a psychiatric disorder in which there is altered handling of signals which otherwise are useful in survival/longevity.

Author(s): 
Spencer, R. P.
Publication Title: 
Biochemical Society Transactions
Author(s): 
Hales, C. N.
Desai, M.
Ozanne, S. E.
Crowther, N. J.

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