Statistics as Topic

Publication Title: 
Mechanisms of Ageing and Development

Accessible and readily utilized software, tables and approximation formulae have been developed to estimate power and sample size for studies of time to event (survival times) when the survival times are assumed to be exponential. These methods can markedly misestimate power when the distribution is Weibull and not exponential. The Weibull distribution with increasing hazard is common in aging research, especially when the whole life span of the subjects is of interest.

Author(s): 
Heo, M.
Faith, M. S.
Allison, D. B.
Publication Title: 
The International Journal of Biochemistry & Cell Biology

Calorie-restricted feeding retards the rate of ageing in mammalian and invertebrate species. The molecular mechanisms underlying this effect include a lower rate of accrual of tissue oxidative damage that is associated with a significantly lower rate of mitochondrial free radical generation in rodent species. To identify the important sites of control and regulation for mitochondrial free radical generation during ageing and calorie-restricted feeding, metabolic control analysis is being applied to the study of mitochondrial bioenergetics.

Author(s): 
Merry, B. J.
Publication Title: 
Molecular Psychiatry

Telomeres are DNA-protein complexes that cap linear DNA strands, protecting DNA from damage. When telomeres critically shorten, cells become susceptible to senescence and apoptosis. Telomerase, a cellular ribonucleoprotein enzyme, rebuilds the length of telomeres and promotes cellular viability. Leukocyte telomeres are reportedly shortened in major depression, but telomerase activity in depression has not been previously reported.

Author(s): 
Wolkowitz, O. M.
Mellon, S. H.
Epel, E. S.
Lin, J.
Reus, V. I.
Rosser, R.
Burke, H.
Compagnone, M.
Nelson, J. C.
Dhabhar, F. S.
Blackburn, E. H.
Publication Title: 
Psychoneuroendocrinology

Allostatic load, the physiological accumulation of the effects of chronic stressors, has been associated with multiple adverse health outcomes. Flattened diurnal cortisol rhythmicity is one of the prototypes of allostatic load, and has been shown to predict shorter survival among women with metastatic breast cancer. The current study compared diurnal cortisol slope in 17 breast cancer patients and 31 controls, and tested associations with variables previously found to be related to cortisol regulation, i.e, abdominal adiposity, perceived stress, social support, and explicit memory.

Author(s): 
Abercrombie, Heather C.
Giese-Davis, Janine
Sephton, Sandra
Epel, Elissa S.
Turner-Cobb, Julie M.
Spiegel, David
Publication Title: 
Molecular Psychiatry

Telomeres are DNA-protein complexes that cap linear DNA strands, protecting DNA from damage. When telomeres critically shorten, cells become susceptible to senescence and apoptosis. Telomerase, a cellular ribonucleoprotein enzyme, rebuilds the length of telomeres and promotes cellular viability. Leukocyte telomeres are reportedly shortened in major depression, but telomerase activity in depression has not been previously reported.

Author(s): 
Wolkowitz, O. M.
Mellon, S. H.
Epel, E. S.
Lin, J.
Reus, V. I.
Rosser, R.
Burke, H.
Compagnone, M.
Nelson, J. C.
Dhabhar, F. S.
Blackburn, E. H.
Publication Title: 
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics

Protocadherin X and Protocadherin Y (PCDHX and PCDHY) are cell-surface adhesion molecules expressed predominantly in the brain. The PCDHX/Y gene-pair was generated by an X-Y translocation approximately 3 million years ago (MYA) that gave rise to the Homo sapiens-specific region of Xq21.3 and Yp11.2 homology. Genes within this region are expected to code for sexually dimorphic human characteristics, including, for example, cerebral asymmetry a dimension of variation that has been suggested is relevant to psychosis.

Author(s): 
Giouzeli, Maria
Williams, Nic A.
Lonie, Lorne J.
DeLisi, Lynn E.
Crow, Timothy J.
Publication Title: 
Psychiatrische Praxis

There is compelling evidence from family, twin and adoption studies of a substantial genetic contribution to schizophrenia. The mode of transmission is complicated and very rarely if ever involves a single gene. Rather schizophrenia results from multiple genes of small effect and their interplay with the environment. Perhaps because the overall size of the genetic effect is large, accounting for about 80 % of variance, definite environmental factors have been difficult to pin down.

Author(s): 
McGuffin, Peter
Publication Title: 
Schizophrenia Research

INTRODUCTION: HTR2A gene has been the subject of numerous studies in psychiatric genetics because LSD, which resembles serotonin causes psychosis and atypical antipsychotic drugs target the HTR2A receptor. However, evidence for the role of HTR2A polymorphism(s) in schizophrenia (SCZ) and bipolar disorder (BD) has been elusive. We hypothesized that epigenetic dysregulation of HTR2A may be involved in psycho-pathogenesis and analyzed promoter DNA methylome and expression of HTR2A in SCZ, BD and control subjects.

Author(s): 
Abdolmaleky, Hamid Mostafavi
Yaqubi, Sahab
Papageorgis, Panagiotis
Lambert, Arthur W.
Ozturk, Sait
Sivaraman, Vadivelu
Thiagalingam, Sam
Publication Title: 
Schizophrenia Research

INTRODUCTION: To improve the understanding of psychotic abnormalities and their non-Mendelian inheritance patterns, the epigenetic regulation of the psychotic disorder-associated GABRB2, gene for the type A ?-aminobutyric acid receptor ?(2)-subunit, was investigated. METHODS: Expression of GABRB2, and the epigenetic regulatory enzymes histone deacetylases (HDACs) and DNA methyltransferases (DNMTs) in mouse and postmortem human brains was analyzed using real-time PCR.

Author(s): 
Zhao, Cunyou
Wang, Feng
Pun, Frank W.
Mei, Lingling
Ren, Lihuan
Yu, Zhiliang
Ng, Siu-Kin
Chen, Jianhuan
Tsang, Shui-Ying
Xue, Hong
Publication Title: 
The International Journal of Neuropsychopharmacology

The synapsin family of neuronal phosphoproteins is composed of three genes (SYN1, SYN2 and SYN3) with alternative splicing resulting in a number of variants with various levels of homology. These genes have been postulated to play significant roles in several neuropsychiatric disorders, including bipolar disorder, schizophrenia and epilepsy. Epigenetic regulatory mechanisms, such as histone modifications in gene regulatory regions, have also been proposed to play a role in a number of psychiatric disorders, including bipolar disorder and major depressive disorder.

Author(s): 
Cruceanu, Cristiana
Alda, Martin
Nagy, Corina
Freemantle, Erika
Rouleau, Guy A.
Turecki, Gustavo

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