Stress, Physiological

Publication Title: 
Gynecologic and Obstetric Investigation

Abortion, primarily as a measure of population control, certainly continues to be an emotional, frustrating and stressful event. In continuation of our work on stressful situations in the female life span and biochemical parameters, serum lipid peroxide levels in terms of malondialdehyde (nmol/ml) have been determined in females undergoing abortion [suction curettage (n = 30), Emcredil-induced abortion (n = 30) and spontaneous abortion (n = 40)] and were compared with appropriate gestational controls.

Author(s): 
Sane, A. S.
Chokshi, S. A.
Mishra, V. V.
Barad, D. P.
Shah, V. C.
Nagpal, S.
Publication Title: 
Aging Cell

Molecular advances of the past decade have led to the discovery of a myriad of 'aging genes' (methuselah, Indy, InR, Chico, superoxide dismutase) that extend Drosophila lifespan by up to 85%. Despite this life extension, these mutants are no longer lived than at least some recently wild-caught strains. Typically, long-lived mutants are identified in relatively short-lived genetic backgrounds, and their effects are rarely tested in genetic backgrounds other than the one in which they were isolated or derived.

Author(s): 
Spencer, Christine C.
Howell, Christine E.
Wright, Amber R.
Promislow, Daniel E. L.
Publication Title: 
Biogerontology

The premature ageing ataxia telangiectasia (AT) and Werner syndromes (WS) are associated with accelerated cellular ageing. Young WS fibroblasts have an aged appearance and activated p38 MAP kinase, and treatment with the p38 inhibitor SB230580 extends their lifespan to within the normal range. SB203580 also extends the replicative lifespan of normal adult dermal fibroblasts, however, the effect is much reduced when compared to WS cells, suggesting that WS fibroblasts undergo a form of stress-induced premature senescence (SIPS).

Author(s): 
Davis, Terence
Kipling, David
Publication Title: 
International Journal of Biological Sciences

Studies of the molecular mechanisms that are involved in stress responses (environmental or physiological) have long been used to make links to disease states in humans. The nematode model organism, Caenorhabditis elegans, undergoes a state of hypometabolism called the 'dauer' stage. This period of developmental arrest is characterized by a significant reduction in metabolic rate, triggered by ambient temperature increase and restricted oxygen/ nutrients. C.

Author(s): 
Lant, Benjamin
Storey, Kenneth B.
Publication Title: 
Experimental Gerontology

As in the case of aging, many degenerative disorders also result from progressive mitochondrial deterioration and cellular damage accumulation. Therefore, preventing damage accumulation may delay aging and help to prevent degenerative disorders, especially those associated with mitochondrial dysfunction. In the nematode Caenorhabditis elegans a mild mitochondrial dysfunction prolongs the lifespan.

Author(s): 
Torgovnick, Alessandro
Schiavi, Alfonso
Testi, Roberto
Ventura, Natascia
Publication Title: 
The Journal of Surgical Research

BACKGROUND: Lifespan extension is achieved through long-term application of dietary restriction (DR), and benefits of short-term dietary restriction on acute stress and inflammation have been observed. So far, the effects of short-term DR in humans are relatively unknown. We hypothesized that short-term DR in humans reduces the acute phase response following a well defined surgical trauma. METHODS: Thirty live kidney donors were randomized between 30% preoperative dietary restriction followed by 1 d of fasting (n=17) or a 4 d ad libitum regimen (n=13) prior to surgery.

Author(s): 
van Ginhoven, Tessa M.
Dik, Willem A.
Mitchell, James R.
Smits-te Nijenhuis, Marja A.
van Holten-Neelen, Conny
Hooijkaas, Herbert
Hoeijmakers, Jan H. J.
de Bruin, Ron W. F.
IJzermans, Jan N. M.
Publication Title: 
Biogerontology

Hormesis, the beneficial effect of a mild stress, has been proposed as a means to prolong the period of healthy ageing as it can increase the average lifespan of a cohort. However, if we want to use hormesis therapeutically it is important that the treatment is beneficial on the individual level and not just on average at the population level. Long lived lines have been shown not to benefit from a, in other lines, hormesis inducing heat treatment in Drosophila melanogaster, D. buzzatii and mice.

Author(s): 
Sarup, Pernille
Loeschcke, Volker
Publication Title: 
PloS One

Hormesis occurs when a low level stress elicits adaptive beneficial responses that protect against subsequent exposure to severe stress. Recent findings suggest that mild oxidative and thermal stress can extend lifespan by hormetic mechanisms. Here we show that the botanical pesticide plumbagin, while toxic to C. elegans nematodes at high doses, extends lifespan at low doses. Because plumbagin is a naphthoquinone that can generate free radicals in vivo, we investigated whether it extends lifespan by activating an adaptive cellular stress response pathway. The C.

Author(s): 
Hunt, Piper R.
Son, Tae Gen
Wilson, Mark A.
Yu, Quian-Sheng
Wood, William H.
Zhang, Yongqing
Becker, Kevin G.
Greig, Nigel H.
Mattson, Mark P.
Camandola, Simonetta
Wolkow, Catherine A.
Publication Title: 
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et MÈtabolisme

Compounds that delay aging in model organisms may be of significant interest to antiaging medicine, since these substances potentially provide pharmaceutical approaches to promote healthy lifespan in humans. The aim of the study was to test whether pharmaceutical concentrations of the glycolytic inhibitor lonidamine are capable of extending lifespan in a nematodal model organism for aging processes, the roundworm Caenorhabditis elegans. Several hundreds of adult C. elegans roundworms were maintained on agar plates and fed E. coli strain OP50 bacteria.

Author(s): 
Schmeisser, S.
Zarse, K.
Ristow, M.
Publication Title: 
Gerontology

BACKGROUND: Studies comparing similar-sized species with disparate longevity may elucidate novel mechanisms that abrogate aging and prolong good health. We focus on the longest living rodent, the naked mole-rat. This mouse-sized mammal lives ~8 times longer than do mice and, despite high levels of oxidative damage evident at a young age, it is not only very resistant to spontaneous neoplasia but also shows minimal decline in age-associated physiological traits.

Author(s): 
Lewis, Kaitlyn N.
Mele, James
Hornsby, Peter J.
Buffenstein, Rochelle

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