Pain Measurement

Publication Title: 
Cancer Chemotherapy and Pharmacology

PURPOSE: Chemoneuropathy remains a painful, burdensome complication of cancer treatment for patients receiving a range of chemotherapeutics, yet the cause and persistence of this condition are not fully documented. This study was designed to quantify the longevity of and contributions to neuropathy following treatment with the plant alkaloids paclitaxel and vincristine.

Boyette-Davis, Jessica A.
Cata, Juan P.
Driver, Larry C.
Novy, Diane M.
Bruel, Brian M.
Mooring, Deidre L.
Wendelschafer-Crabb, Gwen
Kennedy, William R.
Dougherty, Patrick M.
Publication Title: 
The Journal of Pain: Official Journal of the American Pain Society

Telomere length, considered a measure of biological aging, is linked to morbidity and mortality. Psychosocial factors associated with shortened telomeres are also common in chronic pain; yet, little is known about telomere length in pain populations. Leukocyte telomere length was evaluated in 66 women with fibromyalgia and 22 healthy female controls. Participants completed questionnaires and a subgroup of fibromyalgia patients underwent quantitative sensory testing (QST; n = 12) and neuroimaging (n = 12). Telomere length was measured using the quantitative polymerase chain reaction method.

Hassett, Afton L.
Epel, Elissa
Clauw, Daniel J.
Harris, Richard E.
Harte, Steven E.
Kairys, Anson
Buyske, Steven
Williams, David A.
Publication Title: 
Progress in Neuro-Psychopharmacology & Biological Psychiatry

5-HT2A receptor density in prefrontal cortex was associated with depression and suicide. 5-HT2A receptor gene polymorphism rs6313 was associated with 5-HT2A receptor binding potential, with the ability of individuals to use environmental support in order to prevent depression, and with sleep improvement after antidepressant treatment with mirtazapine. Studies on response to antidepressant drugs gave inconsistent results.

Benedetti, Francesco
Barbini, Barbara
Bernasconi, Alessandro
Fulgosi, Mara Cigala
Colombo, Cristina
Dallaspezia, Sara
Gavinelli, Chiara
Marino, Elena
Pirovano, Adele
Radaelli, Daniele
Smeraldi, Enrico
Publication Title: 
Journal of Pediatric Psychology

OBJECTIVE: Fear of pain and pain catastrophizing are prominent risk factors for pediatric chronic pain-related maladjustment. Although resilience has largely been ignored in the pediatric pain literature, prior research suggests that optimism might benefit youth and can be learned. We applied an adult chronic pain risk-resilience model to examine the interplay of risk factors and optimism on functioning outcomes in youth with chronic pain. METHOD: Participants included 58 children and adolescents (8-17 years) attending a chronic pain clinic and their parents.

Cousins, Laura A.
Cohen, Lindsey L.
Venable, Claudia
Publication Title: 
The Journal of Pain: Official Journal of the American Pain Society

The clinical pattern of neuropathic pain, diagnosed using the quantitative sensory testing (QST) battery (German Research Network on Neuropathic Pain), could be partly mimicked in healthy volunteers after topical capsaicin application. However, similar to clinical neuropathic pain that develops in only a subgroup of patients who have a neurologic lesion, this attempt to mimick a neuropathic pain pattern succeeded only in a small fraction (18%) of healthy individuals.

Dimova, Violeta
Oertel, Bruno G.
Kabakci, G¸lden
Zimmermann, Michael
Hermens, Hanneke
Lautenbacher, Stefan
Ultsch, Alfred
Lˆtsch, Jˆrn
Publication Title: 
Journal of Advanced Nursing

Spirituality is an important though often neglected aspect of pain in patients with human immunodeficiency virus (HIV) and/or cancer, for both patients and nurses. The spiritual domain involves: (1) meaning, (2) hope and (3) love and relatedness. The author examines spiritual aspects of pain in persons with HIV and/or cancer, as supported by the literature. Understanding spiritual aspects of pain carries implications for nursing. One of these implications is that it is important for the nurse to be closer to his/her own spirit in order to be there for the patient in pain.

Newshan, G.
Publication Title: 
Pain Medicine (Malden, Mass.)

OBJECTIVE: Individuals involved in the early stages of a passionate romantic relationship can be consumed by the experience and report emotional dependence and constant focus on their romantic partner. A few studies have shown that viewing pictures of a romantic partner can significantly reduce experimental pain. The strength of the effect, however, varies substantially between individuals. To study why some individuals experience significant pain reduction when looking at a picture of their partner, we examined partner preoccupation.

Nilakantan, Aneesha
Younger, Jarred
Aron, Arthur
Mackey, Sean
Publication Title: 

Self-compassion is the ability to respond to one's failures, shortcomings, and difficulties with kindness and openness rather than criticism. This study, which might be regarded as a proof-of-concept study, aimed to establish whether self-compassion is associated with expected emotional responses and the likelihood of responding with problem solving, support seeking, distraction, avoidance, rumination, or catastrophizing to unpleasant self-relevant events occurring in 3 social contexts.

Purdie, Fiona
Morley, Stephen
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

OBJECTIVES: Although pediatric patients with chronic pain often turn to complementary therapies, little is known about patients who seek academic integrative pediatric care. DESIGN: The study design comprised abstraction of intake forms and physician records from new patients whose primary concern was pain. SETTING/LOCATION: The study setting was an academic pediatric clinic between January 2010 and December 2011. SUBJECTS: Of the 110 new patients, 49 (45%) had a primary concern about headache (20), abdominal pain (18), or musculoskeletal pain (11).

Young, Lari
Kemper, Kathi J.
Publication Title: 
Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology

Personality traits have been shown to interact with environmental cues to modulate biological responses including treatment responses, and potentially having a role in the formation of placebo effects. Here, we assessed psychological traits in 50 healthy controls as to their capacity to predict placebo analgesic effects, placebo-induced activation of ?-opioid neurotransmission and changes in cortisol plasma levels during a sustained experimental pain challenge (hypertonic saline infused in the masseter muscle) with and without placebo administration.

PeciÒa, Marta
Azhar, Hamdan
Love, Tiffany M.
Lu, Tingting
Fredrickson, Barbara L.
Stohler, Christian S.
Zubieta, Jon-Kar


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