The use of hypnotherapy to modify the reactions of 13 patients undergoing pedicle flap operations is described. The morale and mental approach of these patients was improved. Premedication and hypnotic drug requirements were reduced to nil following hypnotic training. Analgesic medication was also reduced, not being required at all following nearly two-thirds of the operations.
Probenecid increases plasma ketamine levels in mice concurrently with an enhancement of duration of loss of righting reflex. The magnitude of these changes is directly related to the dose of ketamine and intervals between administration of compounds. Plasma levels of anesthetic are similar for all animals upon termination of hypnosis.
In male Sprague-Dawley rats acute ethanol (1.0 and 2.0 g/kg) produced impairment of motor coordination and induced hypnosis (4.0 g/kg). Muscimol (1.25 mg/kg, IP) prior to ethanol administration enhanced motor impairment as measured by the aerial righting reflex. The rate of ethanol disappearance from the blood was unaltered by muscimol. Functional tolerance to the effect of ethanol on sleep time was produced by a 24 hr ethanol inhalation procedure. Animals tested 48 hr after ethanol inhalation exhibited a reduced sleep time from ethanol (4.0 g/kg).
This study was performed to test the hypothesis that sedation after recovery from pharmacologic hypnosis is less pronounced if hypnosis is induced with a midazolam-morphine combination compared with midazolam administered alone. Loss of the righting reflex was used as an index for the hypnotic effect and reduction of locomotor activity as an index for the sedative effect. One group of rats received midazolam (20 mg/kg i.v) and another group an equipotent (in relation to the hypnotic ef.fect) combination of midazolam (4 mg/kg i.v.) and morphine (1.3 mg/kg i.v.).
BACKGROUND AND PURPOSE: Studies support techniques of intraoperative adjustment under general anesthesia, of eye muscle surgery, based upon the rest position (deviation) to improve surgical results. None, however, have examined the (a)symmetry, per se, of the rest position and its influence on surgical outcomes. METHODS: Retrospective/prospective patient chart data and photographs taken of patients under anesthesia were judged for (a)symmetry of deviation and correlated with (a)symmetry of surgery performed on 51 exotropic patients.