Dose-Response Relationship, Radiation

Publication Title: 
Mutation Research

Human diploid fibroblasts, strain MRC-5, were sequentially irradiated with 60Co gamma rays at intervals during their in vitro lifespan. The results indicate that 3 or 6 doses of 1 Gy can increase lifespan, and the same was true for cells treated with 3 doses of 3 Gy. Higher doses (5 x 3 Gy) did reduce growth potential, suggesting either that mid-late passage cells become more sensitive to radiation, or that doses beyond a given threshold reduce population lifespan by multiple cellular hits. The life extension induced by gamma rays might be due to an induced hypermethylation of DNA.

Author(s): 
Holliday, R.
Publication Title: 
International Journal of Radiation Oncology, Biology, Physics

PURPOSE: To investigate the incidence of and variables associated with clinically evident fat necrosis in women treated on a protocol of high-dose-rate (HDR) brachytherapy alone without external-beam whole-breast irradiation for early-stage breast carcinoma. METHODS AND MATERIALS: From 6/1997 until 8/1999, 30 women diagnosed with Stage I or II breast carcinoma underwent surgical excision and postoperative irradiation via HDR brachytherapy implant as part of a multi-institutional clinical Phase I/II protocol.

Author(s): 
Wazer, D. E.
Lowther, D.
Boyle, T.
Ulin, K.
Neuschatz, A.
Ruthazer, R.
DiPetrillo, T. A.
Publication Title: 
Human & Experimental Toxicology
Author(s): 
Boxenbaum, H.
Publication Title: 
Brain Research Bulletin

The role of alterations in mismatch negativity (MMN) in hypnosis was examined by recording MMN of the auditory ERP at frontal (F3, Fz, and F4) and mastoid (M1 and M2) placements. Frontal MMN is believed to reflect activity in right anterior cortical generators, whereas MMN at mastoid leads reflects generators located bilaterally in the temporal auditory cortex. MMN recordings were obtained in 11 low and 12 high hypnotically susceptible participants in three successive blocks; pre-hypnosis, hypnosis and post-hypnosis.

Author(s): 
Jamieson, Graham A.
Dwivedi, Prabudha
Gruzelier, John H.
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

The effects of 10 mg/kg of triphala extract (TE) was studied on radiation-induced sickness and mortality in mice exposed to 7-12 Gray (Gy) of gamma-irradiation. Treatment of mice with triphala once daily for 5 consecutive days before irradiation delayed the onset of mortality and reduced the symptoms of radiation sickness when compared with the non-drug double distilled water treated irradiated controls (DDW). Triphala provided protection against both gastrointestinal and hemopoetic death.

Author(s): 
Jagetia, Ganesh Chandra
Malagi, Krishna J.
Baliga, Manjeshwar Shrinath
Venkatesh, Ponemone
Veruva, Rosi Reddy
Publication Title: 
Die Nahrung

The effect of 5, 10, 20, 40, 60, 80, 100, 120, and 160 mg/kg body weight (b.wt.) of aqueous extract of cystone (an ayurvedic herbal medicine) administered intraperitoneally was studied on the radiation-induced mortality in mice exposed to 10 Gy of gamma-radiation. Treatment of mice with different doses of cystone, consecutively for five days before irradiation, delayed the onset of mortality and reduced the symptoms of radiation sickness when compared with the non-drug treated irradiated controls.

Author(s): 
Jagetia, Ganesh Chandra
Baliga, Manjeshwar Shrinath
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

The effects of 10 mg/kg of triphala extract (TE) was studied on radiation-induced sickness and mortality in mice exposed to 7-12 Gray (Gy) of gamma-irradiation. Treatment of mice with triphala once daily for 5 consecutive days before irradiation delayed the onset of mortality and reduced the symptoms of radiation sickness when compared with the non-drug double distilled water treated irradiated controls (DDW). Triphala provided protection against both gastrointestinal and hemopoetic death.

Author(s): 
Jagetia, Ganesh Chandra
Malagi, Krishna J.
Baliga, Manjeshwar Shrinath
Venkatesh, Ponemone
Veruva, Rosi Reddy
Publication Title: 
Advances in Experimental Medicine and Biology

This chapter gives an overview of the radioprotective and radiosensitizing effect of curcumin. Ionizing radiations interact with biological molecules inducing radiolytic products like e(aq), *OH, *H, -OH, +H, O2, and peroxides. These free radicals damage important biomolecules and subsequently inflict deleterious effects in the organism.

Author(s): 
Jagetia, Ganesh C.
Publication Title: 
Neuroscience

Women have greater temporal summation of experimental pain stimuli and also have a higher propensity for developing chronic visceral pain conditions. Sex hormone-mediated regulation of N-methyl-d-aspartic acid receptors (NMDARs) in nociceptive pathways is a plausible mechanism that may underlie these phenomena. The aim of this study was to compare the effect of 17-beta-estradiol (E2) in modulation of NMDAR activity in adult male and female rat dorsal root ganglia (DRG) neurons. DRG neurons were collected from adult male or female rats and grown in short-term culture in steroid-free media.

Author(s): 
McRoberts, J. A.
Li, J.
Ennes, H. S.
Mayer, E. A.
Publication Title: 
American Journal of Physiology. Heart and Circulatory Physiology

External application of static magnetic fields (SMF), used specifically for the treatment of inflammatory conditions such as soft tissue injuries, has recently become popular as a complementary and/or alternative therapy with minimal investigation into efficacy or mechanism. Localized inflammation was induced via injection of inflammatory agents lambda-carrageenan (CA) or histamine into rat hindpaws, alone or in conjunction with pharmacological agents, resulting in a spatially and temporally defined inflammatory reaction.

Author(s): 
Morris, Cassandra E.
Skalak, Thomas C.

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