Publication Title: 
Pharmaceutical Biology

Context Chebulae Fructus is used as an herbal remedy for diarrhoea in traditional Chinese medicine. However, there is no scientific evidence to support its antidiarrhoeal activity. Objective This study evaluates the antidiarrhoeal properties of Chebulae Fructus aqueous extract (CFAE) and determines the active fraction. Materials and methods The antidiarrhoeal effect of CFAE (200-800?mg/kg) was investigated by determining the wet dropping, intestinal transit in BALB/c mice and enteropooling in Wister rats.

Sheng, Zunlai
Yan, Xin
Zhang, Ruili
Ni, Huilin
Cui, Yuanxu
Ge, Junwei
Shan, Anshan
Publication Title: 
Animal Science Journal = Nihon Chikusan Gakkaiho

This study investigates the effects of Terminalia chebula Retz. meal supplementation on rumen fermentation and methane (CH4 ) production by using an in vitro gas technique. The experimental design was a completely randomized design (CRD) and the dietary treatments were T. chebula supplementation at 0, 4, 8, 12, 16 and 20?mg with 0.5?g of roughage and concentrate ratio at 60:40. The results revealed that cumulative gas production (96?h of incubation) were higher (P?<?0.01) with T. chebula supplementation at 12, 16 and 20?mg than other treatments.

Anantasook, Nirawan
Wanapat, Metha
Gunun, Pongsatorn
Cherdthong, Anusorn
Publication Title: 
Basic & Clinical Pharmacology & Toxicology

Transient receptor potential melastatin 7 (TRPM7) plays a role in a number of physiological and pharmacological functions in variety of cells. The aim of this study was to clarify the role for TRPM7 channels and the effect of waixenicin A on the pacemaking activity of interstitial cells of Cajal (ICCs) and on the cell viability of the human gastric and breast adenocarcinoma cell lines, AGS and MCF-7, respectively.

Kim, Byung J.
Nam, Joo H.
Kwon, Young K.
So, Insuk
Kim, Seon J.
Publication Title: 
Archives of Biochemistry and Biophysics
Blackburn, E. H.
Hird, F. J.
Jones, I. K.
Publication Title: 
Current Gastroenterology Reports

Functional dyspepsia (FD) is common in children, with as many as 80% of those being evaluated for chronic abdominal pain reporting symptoms of epigastric discomfort, nausea, or fullness. It is known that patients with persistent complaints have increased comorbidities such as depression and anxiety. The interaction with psychopathologic variables has been found to mediate the association between upper abdominal pain and gastric hypersensitivity. These observations suggest that abnormal central nervous system processing of gastric stimuli may be a relevant pathophysiologic mechanism in FD.

Perez, Maria E.
Youssef, Nader N.
Publication Title: 
PloS One

BACKGROUND: Artemisinin derivatives are the key active ingredients in Artemisinin combination therapies (ACTs), the most effective therapies available for treatment of malaria. Because the raw material is extracted from plants with long growing seasons, artemisinin is often in short supply, and fermentation would be an attractive alternative production method to supplement the plant source.

Tsuruta, Hiroko
Paddon, Christopher J.
Eng, Diana
Lenihan, Jacob R.
Horning, Tizita
Anthony, Larry C.
Regentin, Rika
Keasling, Jay D.
Renninger, Neil S.
Newman, Jack D.
Publication Title: 
Molecular Plant

Plants of Artemisia annua produce artemisinin, a sesquiterpene lactone widely used in malaria treatment. Amorpha-4,11-diene synthase (ADS), a sesquiterpene synthase, and CYP71AV1, a P450 monooxygenase, are two key enzymes of the artemisinin biosynthesis pathway. Accumulation of artemisinin can be induced by the phytohormone jasmonate (JA). Here, we report the characterization of two JA-responsive AP2 family transcription factors--AaERF1 and AaERF2--from A. annua L. Both genes were highly expressed in inflorescences and strongly induced by JA.

Yu, Zong-Xia
Li, Jian-Xu
Yang, Chang-Qing
Hu, Wen-Li
Wang, Ling-Jian
Chen, Xiao-Ya
Publication Title: 
PloS One

The present day lifestyle heavily depends on industrial chemicals in the form of agriculture, cosmetics, textiles and medical products. Since the toxicity of the industrial chemicals has been a concern to human health, the need for alternative non-toxic natural products or adjuvants that serve as antidotes are in high demand. We have investigated the effects of Ayurvedic herb Ashwagandha (Withania somnifera) leaf extract on methoxyacetic acid (MAA) induced toxicity.

Priyandoko, Didik
Ishii, Tetsuro
Kaul, Sunil C.
Wadhwa, Renu
Publication Title: 
Journal of Ethnopharmacology

Embelin, a p-quinone, is derived from Embelia ribes Burm. The analgesic effect of potassium embelate has been studied in rats and mice. The test drug was found to be effective by oral, i.m. and i.c.v. routes and the results compared well with morphine. Although potassium embelate acts centrally to produce analgesia, its effect is not antagonized by naloxone indicating a different central site of action. There is no precipitation of abstinence syndrome as observed with morphine. Peripheral site of action of the drug is ruled out as it lacks any demonstrable anti-inflammatory action.

Atal, C. K.
Siddiqui, M. A.
Zutshi, U.
Amla, V.
Johri, R. K.
Rao, P. G.
Kour, S.
Publication Title: 
Indian Journal of Experimental Biology

Argyreia speciosa (sweet) (Burm.f.) Boj. is an Ayurvedic rasayana plant used as an adaptogen. The present study reports the investigations done on the adaptogenic property of ethanol (EtAS; 100 and 200 mg/kg; po), ethyl acetate (EAAS; 100 and 200 mg/kg; po) fraction and flavanoids such as quercetin and kaempferol (25 mg/kg; po) of the root. Immobilization induced acute stress (AS; 3 days) and chronic stress (CS; 7 days) and swimming induced stress models were used to screen the anti-stress effect of the plant fractions and isolated flavanoids.

Habbu, P. V.
Mahadevan, K. M.
Kulkarni, P. V.
Daulatsingh, C.
Veerapur, V. P.
Shastry, R. A.


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